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7,043 results

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Page 1
SH2 Domain Binding: Diverse FLVRs of Partnership.
Jaber Chehayeb R, Boggon TJ. Jaber Chehayeb R, et al. Front Endocrinol (Lausanne). 2020 Sep 18;11:575220. doi: 10.3389/fendo.2020.575220. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33042028 Free PMC article. Review.
The Src homology 2 (SH2) domain has a special role as one of the cornerstone examples of a "modular" domain. ...Recent work has, however, highlighted unusual features of the SH2 domain that illustrate a greater diversity than was p …
The Src homology 2 (SH2) domain has a special role as one of the cornerstone examples of a "modular" domain …
SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
Kasembeli MM, Xu X, Tweardy DJ. Kasembeli MM, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14(3):1010-22. doi: 10.2741/3292. Front Biosci (Landmark Ed). 2009. PMID: 19273114 Free article. Review.
SH2 domains are modular components of a wide range of functionally diverse proteins involved in mammalian signal transduction including enzymes, adaptors, regulators and transcription factors. Members of the SH2 domain family recognize a wide variety o …
SH2 domains are modular components of a wide range of functionally diverse proteins involved in mammalian signal transduction …
Grb2 SH2 domain-binding peptide analogs as potential anticancer agents.
Lung FD, Tsai JY. Lung FD, et al. Biopolymers. 2003;71(2):132-40. doi: 10.1002/bip.10396. Biopolymers. 2003. PMID: 12767115 Review.
Blocking the interaction between the phosphotyrosine-containing activated receptor and the Src-homology 2 (SH2) domain of Grb2 thus constitutes an important strategy for the development of potential anticancer agents. ...We review here the variety of a …
Blocking the interaction between the phosphotyrosine-containing activated receptor and the Src-homology 2 (SH2) doma …
Lipid Binding of SH2 Domains.
Cho W, Berkley K, Sharma A. Cho W, et al. Methods Mol Biol. 2023;2705:239-253. doi: 10.1007/978-1-0716-3393-9_13. Methods Mol Biol. 2023. PMID: 37668978
The Src homology 2 (SH2) domain is a modular protein interaction domain that specifically recognizes the phosphotyrosine (pY) motif of a target molecule. ...Lipid binding of SH2 domain-containing kinases and phosphatases is …
The Src homology 2 (SH2) domain is a modular protein interaction domain that specifically recognizes the …
Tensin.
Lo SH. Lo SH. Int J Biochem Cell Biol. 2004 Jan;36(1):31-4. doi: 10.1016/s1357-2725(03)00171-7. Int J Biochem Cell Biol. 2004. PMID: 14592531 Review.
These interactions allow tensin to link actin filaments to integrin receptors. In addition, tensin has an Src Homology 2 (SH2) domain capable of interacting with tyrosine-phosphorylated proteins. ...Thus, tensin functions as a platform for dis/assembly …
These interactions allow tensin to link actin filaments to integrin receptors. In addition, tensin has an Src Homology 2 (S …
SH2 Domain Histochemistry.
Buhs S, Nollau P. Buhs S, et al. Methods Mol Biol. 2017;1555:535-545. doi: 10.1007/978-1-4939-6762-9_31. Methods Mol Biol. 2017. PMID: 28092054
Based on the unique properties of endogenously expressed SH2 domains recognizing tyrosine phosphorylated signaling proteins with high specificity we have developed an alternative approach, coined SH2 profiling, enabling us to decipher complex patterns of tyro …
Based on the unique properties of endogenously expressed SH2 domains recognizing tyrosine phosphorylated signaling proteins wi …
SH2scan: Mapping SH2 Domain-Ligand Binding Selectivity for Inhibitors and Degraders.
Gonzalez Lira LM, Wolfe-Demarco JK, Clifford AM, Le TD, Khasawneh GM, Kidane M, Nguyen M, Najera JA, Pallares G, Servant NB, Bernatchez JA. Gonzalez Lira LM, et al. J Med Chem. 2026 Feb 26;69(4):3932-3940. doi: 10.1021/acs.jmedchem.5c02613. Epub 2026 Jan 16. J Med Chem. 2026. PMID: 41543922 Free PMC article.
Drug discovery targeting SH2 domains (key protein-protein interaction modules) has been hampered by a lack of assay systems evaluating synthetic ligand binding selectivity toward SH2 domains to reduce potential off-target effects. In addition, t …
Drug discovery targeting SH2 domains (key protein-protein interaction modules) has been hampered by a lack of assay systems ev …
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain.
Di Felice M, Pagano L, Pennacchietti V, Diop A, Pietrangeli P, Marcocci L, Di Matteo S, Malagrinò F, Toto A, Gianni S. Di Felice M, et al. J Biol Chem. 2024 Apr;300(4):107129. doi: 10.1016/j.jbc.2024.107129. Epub 2024 Mar 1. J Biol Chem. 2024. PMID: 38432639 Free PMC article.
This study delves into the energetic communication of Grb2 domains, focusing on the folding and binding properties of the C-SH3 domain linked to its neighboring SH2 domain. ...Through a double mutant cycle analysis, we highlighted a subset of re …
This study delves into the energetic communication of Grb2 domains, focusing on the folding and binding properties of the C-SH …
Mechanism of Folding and Binding of the N-Terminal SH2 Domain from SHP2.
Bonetti D, Troilo F, Toto A, Travaglini-Allocatelli C, Brunori M, Gianni S. Bonetti D, et al. J Phys Chem B. 2018 Dec 13;122(49):11108-11114. doi: 10.1021/acs.jpcb.8b05651. Epub 2018 Aug 7. J Phys Chem B. 2018. PMID: 30047735
In order to shed light on the dynamic and functional properties of this protein-protein interaction, we studied the mechanism of folding of N-SH2 and the binding process to a peptide mimicking a region of Gab2. The data presented represent the first description by s …
In order to shed light on the dynamic and functional properties of this protein-protein interaction, we studied the mechanism of folding of …
Loops govern SH2 domain specificity by controlling access to binding pockets.
Kaneko T, Huang H, Zhao B, Li L, Liu H, Voss CK, Wu C, Schiller MR, Li SS. Kaneko T, et al. Sci Signal. 2010 May 4;3(120):ra34. doi: 10.1126/scisignal.2000796. Sci Signal. 2010. PMID: 20442417 Free PMC article.
The structure of the SH2 domain of BRDG1 bound to a peptide revealed a binding pocket that was blocked by a loop residue in most other SH2 domains. Analysis of 63 SH2 domain structures suggested that the SH2 domains c …
The structure of the SH2 domain of BRDG1 bound to a peptide revealed a binding pocket that was blocked by a loop residu …
7,043 results