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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
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1986 2
1987 2
1988 1
1989 2
1990 2
1991 1
1993 3
1994 4
1995 3
1996 8
1997 13
1998 12
1999 26
2000 32
2001 37
2002 60
2003 63
2004 70
2005 88
2006 96
2007 98
2008 102
2009 113
2010 100
2011 118
2012 87
2013 116
2014 74
2015 61
2016 77
2017 59
2018 51
2019 66
2020 46
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2022 47
2023 9
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1,664 results
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Page 1
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Imai S, et al. Nature. 2000 Feb 17;403(6771):795-800. doi: 10.1038/35001622. Nature. 2000. PMID: 10693811
Lysines 9 and 14 of histone H3 and lysines 5, 8 and 16 of H4 are acetylated in active chromatin and hypoacetylated in silenced chromatin, and overexpression of Sir2 promotes global deacetylation of histones, indicating that Sir2 may be a histone deacetylase. ...Our …
Lysines 9 and 14 of histone H3 and lysines 5, 8 and 16 of H4 are acetylated in active chromatin and hypoacetylated in silenced chromatin, an …
Spreading-dependent or independent Sir2-mediated gene silencing in budding yeast.
Yeom S, Oh J, Lee JS. Yeom S, et al. Genes Genomics. 2022 Mar;44(3):359-367. doi: 10.1007/s13258-021-01203-y. Epub 2022 Jan 16. Genes Genomics. 2022. PMID: 35034281
RESULTS: Using Sir2 ChIP-seq data, we identified that the Sir2 binding domain length caused by Sir2 spreading from the chromosomal end is different in each telomere in budding yeast. Expression of most subtelomeric genes increased in the sir2 strain. S …
RESULTS: Using Sir2 ChIP-seq data, we identified that the Sir2 binding domain length caused by Sir2 spreading from the …
The Sir2 family of protein deacetylases.
Blander G, Guarente L. Blander G, et al. Annu Rev Biochem. 2004;73:417-35. doi: 10.1146/annurev.biochem.73.011303.073651. Annu Rev Biochem. 2004. PMID: 15189148 Review.
In this review, we discuss the role of NAD+, the unusual products of the deacetylation reaction, the Sir2 structure, and the Sir2 chemical inhibitors and activators that were recently identified. We summarize the current knowledge of the Sir2 homologs from di …
In this review, we discuss the role of NAD+, the unusual products of the deacetylation reaction, the Sir2 structure, and the Sir2 …
SIR2: a potential target for calorie restriction mimetics.
Chen D, Guarente L. Chen D, et al. Trends Mol Med. 2007 Feb;13(2):64-71. doi: 10.1016/j.molmed.2006.12.004. Epub 2007 Jan 4. Trends Mol Med. 2007. PMID: 17207661 Review.
We conclude with the recent advances on small molecules that activate the enzymatic activity of SIR2 as potential CR mimetics. The SIR2 family represents an evolutionarily conserved lifespan regulator. Modulating the activity of SIR2 might provide effective C …
We conclude with the recent advances on small molecules that activate the enzymatic activity of SIR2 as potential CR mimetics. The …
Sir2 and calorie restriction in yeast: a skeptical perspective.
Kaeberlein M, Powers RW 3rd. Kaeberlein M, et al. Ageing Res Rev. 2007 Aug;6(2):128-40. doi: 10.1016/j.arr.2007.04.001. Epub 2007 Apr 19. Ageing Res Rev. 2007. PMID: 17512264 Review.
This idea has been called into question with the discovery that Sir2-family proteins are not required for life span extension from CR in yeast. ...Several specific cases where the Sir2 model of CR is inconsistent with experimental data are noted. ...
This idea has been called into question with the discovery that Sir2-family proteins are not required for life span extension from CR …
SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates.
Sauve AA, Schramm VL. Sauve AA, et al. Curr Med Chem. 2004 Apr;11(7):807-26. doi: 10.2174/0929867043455675. Curr Med Chem. 2004. PMID: 15078167 Review.
Principles of the chemistry of stabilized ADPR intermediates are examined for Sir2 and the mechanistically related ADP-ribosylcyclase CD38. An examination of the crystal structures of Sir2 family members is presented with a view to the chemical requirements of the …
Principles of the chemistry of stabilized ADPR intermediates are examined for Sir2 and the mechanistically related ADP-ribosylcyclase …
Sirtuins: Sir2-related NAD-dependent protein deacetylases.
North BJ, Verdin E. North BJ, et al. Genome Biol. 2004;5(5):224. doi: 10.1186/gb-2004-5-5-224. Epub 2004 Apr 28. Genome Biol. 2004. PMID: 15128440 Free PMC article. Review.
Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. ...Sirtuins have also been implicated in regulating the molecular mechanisms o …
Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD …
Sir2 and Reb1 antagonistically regulate nucleosome occupancy in subtelomeric X-elements and repress TERRAs by distinct mechanisms.
Bauer SL, Grochalski TNT, Smialowska A, Åström SU. Bauer SL, et al. PLoS Genet. 2022 Sep 22;18(9):e1010419. doi: 10.1371/journal.pgen.1010419. eCollection 2022 Sep. PLoS Genet. 2022. PMID: 36137093 Free PMC article.
The X-elements contain several binding sites for the transcription factor Reb1 and we found that Sir2 and Reb1 compete for stabilizing/destabilizing this nucleosome, i.e. inactivation of Reb1 in a sir2 background reinstated the lost nucleosome. The telomeric-repeat- …
The X-elements contain several binding sites for the transcription factor Reb1 and we found that Sir2 and Reb1 compete for stabilizin …
Calorie restriction--the SIR2 connection.
Guarente L, Picard F. Guarente L, et al. Cell. 2005 Feb 25;120(4):473-82. doi: 10.1016/j.cell.2005.01.029. Cell. 2005. PMID: 15734680 Free article. Review.
A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and may mediate the effects of calorie restriction. In this review, we discuss SIR2 genes a …
A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, w …
1,664 results