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Lipid metabolism-related gene signature predicts prognosis and unveils novel anti-tumor drugs in specific type of diffuse large B cell lymphoma.
Wang C, Zhang R, Zhang H, Gao H, Zhu Y, Jiao L, Yi Z, Zhou M, Li X. Wang C, et al. Mol Med. 2024 Nov 13;30(1):210. doi: 10.1186/s10020-024-00988-4. Mol Med. 2024. PMID: 39538125 Free PMC article.
RESULTS: Nineteen survival related lipid metabolism genes TMEM176B, LAYN, RAB6B, MMP9, ATAD3B, SLC2A11, CD3E, SLIT2, SLC2A13, SLC43A3, CD6, SIRPG, NEK6, LCP2, CTTN, CXCL2, SNX22, BCL6 and FABP4 were identified and subjected to build the prognostic model which was further v …
RESULTS: Nineteen survival related lipid metabolism genes TMEM176B, LAYN, RAB6B, MMP9, ATAD3B, SLC2A11, CD3E, SLIT2, SLC2A13, SLC43A3 …
Long-standing preservation of levodopa response in progressive supranuclear palsy.
Sano T, Mizutani M, Ishihara T, Hara N, Miyashita A, Ikeuchi T, Hasegawa M, Takahashi Y, Takao M. Sano T, et al. J Neurol Sci. 2024 Nov 15;466:123203. doi: 10.1016/j.jns.2024.123203. Epub 2024 Aug 29. J Neurol Sci. 2024. PMID: 39260141 Free article.
Homozygosity for both the rs564309-C allele at TRIM11 and the rs2242367-G allele at SLC2A13 might have played a protective role. This case indicates a protracted course-PSP, which may hold promise for future treatments....
Homozygosity for both the rs564309-C allele at TRIM11 and the rs2242367-G allele at SLC2A13 might have played a protective role. This …
High-depth whole-genome sequencing identifies structure variants, copy number variants and short tandem repeats associated with Parkinson's disease.
Wang C, Liu H, Li XY, Ma J, Gu Z, Feng X, Xie S, Tang BS, Chen S, Wang W, Wang J, Zhang J, Chan P. Wang C, et al. NPJ Parkinsons Dis. 2024 Jul 23;10(1):134. doi: 10.1038/s41531-024-00722-1. NPJ Parkinsons Dis. 2024. PMID: 39043730 Free PMC article.
After genome-wide association analysis and replication in an external cohort of 352 cases and 547 controls, we validated that the 1.6 kb-deletion neighboring MUC19, 12.4kb-deletion near RXFP1 and GGGAAA repeats in SLC2A13 were significantly associated with PD. Moreover, th …
After genome-wide association analysis and replication in an external cohort of 352 cases and 547 controls, we validated that the 1.6 kb-del …
Novel Circular RNA CircSLC2A13 Regulates Chicken Muscle Development by Sponging MiR-34a-3p.
Jiao Z, Xie T, Wang X, Guo D, Lin S, An L, Lin J, Zhang L. Jiao Z, et al. J Agric Food Chem. 2024 Jul 17;72(28):15530-15540. doi: 10.1021/acs.jafc.4c01550. Epub 2024 Jul 4. J Agric Food Chem. 2024. PMID: 38963795
In this study, we have cloned a novel chicken circular RNA circSLC2A13 generated from the solute carrier family 2 member 13 gene (SLC2A13). Also, circSLC2A1 was confirmed by sequencing verification, RNase R treatment, and reverse transcription analysis. ...
In this study, we have cloned a novel chicken circular RNA circSLC2A13 generated from the solute carrier family 2 member 13 gene (SLC2A13 …
Interaction between caffeine consumption & genetic susceptibility in Parkinson's disease: A systematic review.
Yang Y, Zhou ZD, Yi L, Tan BJ, Tan EK. Yang Y, et al. Ageing Res Rev. 2024 Aug;99:102381. doi: 10.1016/j.arr.2024.102381. Epub 2024 Jun 22. Ageing Res Rev. 2024. PMID: 38914264 Review.
Based on the genetic association and interaction studies, only MAPT, SLC2A13, LRRK2, ApoE, NOS2A, GRIN2A, CYP1A2, and ADORA2A have been shown by at least one study to have a positive caffeine-gene interaction influencing the risk of PD. CONCLUSION: Studies have shown an in …
Based on the genetic association and interaction studies, only MAPT, SLC2A13, LRRK2, ApoE, NOS2A, GRIN2A, CYP1A2, and ADORA2A have be …
Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study.
Ramsay E, Montaser AB, Niitsu K, Urtti A, Auriola S, Huttunen KM, Uchida Y, Kidron H, Terasaki T. Ramsay E, et al. Mol Pharm. 2024 Jul 1;21(7):3204-3217. doi: 10.1021/acs.molpharmaceut.3c01210. Epub 2024 May 29. Mol Pharm. 2024. PMID: 38809137 Free PMC article.
Among these, 15 proteins were quantified in both animals: 4f2hc (Slc3a2), Aqp0, Asct1 (Slc1a4), Asct2 (Slc1a5), Glut1 (Slc2a1), Hmit (Slc2a13), Insr, Lat1 (Slc7a5), Mct1 (Slc16a1), Mct2 (Slc16a7), Mct4 (Slc16a3), Mrp 4 (Abcc4), Na(+)/K(+)-ATPase, Oatp3a1 (Slco3a1), and Sna …
Among these, 15 proteins were quantified in both animals: 4f2hc (Slc3a2), Aqp0, Asct1 (Slc1a4), Asct2 (Slc1a5), Glut1 (Slc2a1), Hmit (Slc …
Transcriptome and Metabolome Analyses Reveal Sugar and Acid Accumulation during Apricot Fruit Development.
Gou N, Chen C, Huang M, Zhang Y, Bai H, Li H, Wang L, Wuyun T. Gou N, et al. Int J Mol Sci. 2023 Nov 30;24(23):16992. doi: 10.3390/ijms242316992. Int J Mol Sci. 2023. PMID: 38069317 Free PMC article.
Additionally, an analysis of the co-expression network of weighted genes unveiled a robust correlation between the brown module and sucrose, glucose, and fructose, with VIP being identified as a hub gene that interacted with four sugar transporter proteins (SLC35B3, SLC32A, SLC2A …
Additionally, an analysis of the co-expression network of weighted genes unveiled a robust correlation between the brown module and sucrose, …
Protracted course progressive supranuclear palsy.
Couto B, Martinez-Valbuena I, Lee S, Alfradique-Dunham I, Perrin RJ, Perlmutter JS, Cruchaga C, Kim A, Visanji N, Sato C, Rogaeva E, Lang AE, Kovacs GG. Couto B, et al. Eur J Neurol. 2022 Aug;29(8):2220-2231. doi: 10.1111/ene.15346. Epub 2022 Apr 21. Eur J Neurol. 2022. PMID: 35384155 Free PMC article.
Time to reach gait dependence and cognitive impairment have been proposed as prognostic disease milestones. Genetic polymorphisms in TRIM11 and SLC2A13 genes have been associated with longer disease duration (DD). METHODS: Methods used include retrospective chart review, g …
Time to reach gait dependence and cognitive impairment have been proposed as prognostic disease milestones. Genetic polymorphisms in TRIM11 …
Restoration of mRNA Expression of Solute Carrier Proteins in Liver of Diet-Induced Obese Mice by Metformin.
Le J, Fu Y, Han Q, Wei X, Ji H, Chen Y, Wang Q, Pi P, Li J, Lin X, Zhang X, Zhang Y, Ye J. Le J, et al. Front Endocrinol (Lausanne). 2021 Sep 30;12:720784. doi: 10.3389/fendo.2021.720784. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34659115 Free PMC article.
Expression of 20 MET-responsive Slc DEGs was confirmed by qRT-PCR, in which 15 Slc genes were altered in DIO mice and their expressions were restored by MET, including Slc2a10, Slc2a13, Slc5a9, Slc6a14, Slc7a9, Slc9a2, Slc9a3, Slc13a2, Slc15a2, Slc26a3, Slc34a2, Slc37a1, S …
Expression of 20 MET-responsive Slc DEGs was confirmed by qRT-PCR, in which 15 Slc genes were altered in DIO mice and their expressions were …
Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.
Li C, Ou R, Chen Y, Gu X, Wei Q, Cao B, Zhang L, Hou Y, Liu K, Chen X, Song W, Zhao B, Wu Y, Shang H. Li C, et al. Neurobiol Aging. 2021 Jul;103:152.e1-152.e6. doi: 10.1016/j.neurobiolaging.2021.02.022. Epub 2021 Mar 1. Neurobiol Aging. 2021. PMID: 33781609
Totally, 58 rare variants were identified in SLC50A1, SLC41A1, SLC45A3, SLC44A4, SLC56A2, SLC2A13 and SLC38A1. At allele level, 6 variants were nominally associated with PD, namely p.S423G in SLC45A3, p.I551V, p.T435S, p.R323C and p.V101M in SLC2A13, and p.R285Q in …
Totally, 58 rare variants were identified in SLC50A1, SLC41A1, SLC45A3, SLC44A4, SLC56A2, SLC2A13 and SLC38A1. At allele level, 6 var …
Placental Inositol Reduced in Gestational Diabetes as Glucose Alters Inositol Transporters and IMPA1 Enzyme Expression.
Pillai RA, Islam MO, Selvam P, Sharma N, Chu AHY, Watkins OC, Godfrey KM, Lewis RM, Chan SY. Pillai RA, et al. J Clin Endocrinol Metab. 2021 Jan 23;106(2):e875-e890. doi: 10.1210/clinem/dgaa814. J Clin Endocrinol Metab. 2021. PMID: 33165596 Free PMC article.
Increasing fasting glycemia was associated with lower protein levels of the myo-inositol synthesis enzyme, IMPA1, and the inositol transporters, SLC5A11 and SLC2A13, the expression of which also correlated with placental inositol content. In vitro, higher glucose concentra …
Increasing fasting glycemia was associated with lower protein levels of the myo-inositol synthesis enzyme, IMPA1, and the inositol transport …
Genome-Wide Assessment of Runs of Homozygosity in Chinese Wagyu Beef Cattle.
Zhao G, Zhang T, Liu Y, Wang Z, Xu L, Zhu B, Gao X, Zhang L, Gao H, Liu GE, Li J, Xu L. Zhao G, et al. Animals (Basel). 2020 Aug 14;10(8):1425. doi: 10.3390/ani10081425. Animals (Basel). 2020. PMID: 32824035 Free PMC article.
Among them, we observed 41 candidate genes, including BCKDHB, MAB21L1, SLC2A13, FGFR3, FGFRL1, CPLX1, CTNNA1, CORT, CTNNBIP1, and NMNAT1, which have been previously reported to be related to body conformation, meat quality, susceptibility, and reproductive traits. ...
Among them, we observed 41 candidate genes, including BCKDHB, MAB21L1, SLC2A13, FGFR3, FGFRL1, CPLX1, CTNNA1, CORT, CTNNBIP1, and NMN …
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
Noreen Z, Loffredo CA, Bhatti A, Simhadri JJ, Nunlee-Bland G, Nnanabu T, John P, Khan JS, Ghosh S. Noreen Z, et al. Int J Environ Res Public Health. 2020 Aug 13;17(16):5866. doi: 10.3390/ijerph17165866. Int J Environ Res Public Health. 2020. PMID: 32823525 Free PMC article.
High-throughput qRT-PCR TaqMan Low Density Array (TLDA) was performed to validate the selected differentially expressed genes of our interest, viz., ARNT, LEPR, MYC, RRAD, CYP2D6, TP53, APOC1, APOC2, CYP1B1, SLC2A13, and SLC33A1 using a small population validation sample ( …
High-throughput qRT-PCR TaqMan Low Density Array (TLDA) was performed to validate the selected differentially expressed genes of our interes …
The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia.
Lai B, Lai Y, Zhang Y, Zhou M, Sheng L, OuYang G. Lai B, et al. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033819894308. doi: 10.1177/1533033819894308. Technol Cancer Res Treat. 2020. PMID: 31918632 Free PMC article.
Kaplan-Meier survival analysis suggested that patients with high SLC2A5 and SLC2A10 expression showed poorer survival than those with low SLC2A5 and SLC2A10 expression. In contrast, patients with high SLC2A13 expression exhibited better prognosis than those with low SLC …
Kaplan-Meier survival analysis suggested that patients with high SLC2A5 and SLC2A10 expression showed poorer survival than those with low SL …
Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies.
Vawter MP, Hamzeh AR, Muradyan E, Civelli O, Abbott GW, Alachkar A. Vawter MP, et al. Mol Neuropsychiatry. 2019 Oct;5(4):200-211. doi: 10.1159/000501125. Epub 2019 Aug 8. Mol Neuropsychiatry. 2019. PMID: 31768373 Free PMC article.
Given that brain MI is differentially regulated by three transporters - SMIT1, SMIT2 and/or HMIT (encoded by the genes: SLC5A3, SLC5A11, and SLC2A13, respectively) - we used available datasets to describe the distribution in mouse and human brain of the different MI transp …
Given that brain MI is differentially regulated by three transporters - SMIT1, SMIT2 and/or HMIT (encoded by the genes: SLC5A3, SLC5A11, and …
The genetic variants in calcium signaling related genes influence anti-tuberculosis drug induced liver injury: A prospective study.
Lyu M, Zhou J, Chen H, Bai H, Song J, Liu T, Cheng Y, Ying B. Lyu M, et al. Medicine (Baltimore). 2019 Nov;98(44):e17821. doi: 10.1097/MD.0000000000017821. Medicine (Baltimore). 2019. PMID: 31689868 Free PMC article.
This study aimed to explore the influence of single nucleotide polymorphisms (SNPs) in Bradykinin receptor B2 (BDKRB2), Teneurin transmembrane protein 2 (TENM2), transforming growth factor beta 2 (TGFB2), and solute carrier family 2 member 13 (SLC2A13) on the risk of ATDIL …
This study aimed to explore the influence of single nucleotide polymorphisms (SNPs) in Bradykinin receptor B2 (BDKRB2), Teneurin transmembra …
The increased expression of glucose transporters in human full-term placentas from assisted reproductive technology without changes of mTOR signaling.
Dong J, Wen L, Guo X, Xiao X, Jiang F, Li B, Jin N, Wang J, Wang X, Chen S, Wang X. Dong J, et al. Placenta. 2019 Oct;86:4-10. doi: 10.1016/j.placenta.2019.08.087. Epub 2019 Aug 29. Placenta. 2019. PMID: 31491693
METHODS: We compared the expression of GLUT family genes (SLC2A1- SLC2A13), mTOR activity, the expression of four imprinted genes (H19, IGF2, CDKN1C and PHLDA2), and KCNQ1OT1 methylation in human placentas conceived naturally or by ART. ...
METHODS: We compared the expression of GLUT family genes (SLC2A1- SLC2A13), mTOR activity, the expression of four imprinted genes (H1 …
Multiple facilitated glucose transporters SLC2As are required for normal mouse preimplantation embryo development.
Arhin SK, Zhao J, Ji X, Shi C, Tang J, Gu Y, Xi H, Cheng J, Qu X, Shi H, Jin X, Lv J. Arhin SK, et al. Am J Transl Res. 2019 Jun 15;11(6):3412-3425. eCollection 2019. Am J Transl Res. 2019. PMID: 31312354 Free PMC article.
The transcription of other Slc2a isoforms was barely detectable or absent after fertilization; however, they were detected in blastocysts, except for Slc2a10 and Slc2a13. Embryo culture in the simple defined medium caused a reduction in transcription of Slc2a1, Slc2a3, Slc …
The transcription of other Slc2a isoforms was barely detectable or absent after fertilization; however, they were detected in blastocysts, e …
Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.
Yang W, Liu H, Duan B, Xu X, Carmody D, Luo S, Walsh KM, Abbruzzese JL, Zhang X, Chen X, Wei Q. Yang W, et al. Cancer Sci. 2019 Jun;110(6):2022-2032. doi: 10.1111/cas.14017. Epub 2019 May 6. Cancer Sci. 2019. PMID: 30972876 Free PMC article.

Furthermore, eQTL analysis showed that both rs3124761 T and rs17458086 C alleles were associated with increased mRNA expression levels of SLC2A6 and SLC2A13, respectively (P < 0.05). In conclusion, genetic variants in NRF2 pathway genes could play a role in susceptibili

…
Furthermore, eQTL analysis showed that both rs3124761 T and rs17458086 C alleles were associated with increased mRNA expression levels of SL …
A genetic association study of carotid intima-media thickness (CIMT) and plaque in Mexican Americans and European Americans with rheumatoid arthritis.
Arya R, Escalante A, Farook VS, Restrepo JF, Battafarano DF, Almeida M, Kos MZ, Fourcaudot MJ, Mummidi S, Kumar S, Curran JE, Jenkinson CP, Blangero J, Duggirala R, Del Rincon I. Arya R, et al. Atherosclerosis. 2018 Apr;271:92-101. doi: 10.1016/j.atherosclerosis.2017.11.024. Epub 2017 Nov 26. Atherosclerosis. 2018. PMID: 29482039 Free PMC article.
Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
Teranishi Y, Inoue M, Yamamoto NG, Kihara T, Wiehager B, Ishikawa T, Winblad B, Schedin-Weiss S, Frykman S, Tjernberg LO. Teranishi Y, et al. FEBS J. 2015 Sep;282(17):3438-51. doi: 10.1111/febs.13353. Epub 2015 Jul 14. FEBS J. 2015. PMID: 26094765 Free article. Review.
Silencing of these reduced Abeta secretion in a small interfering RNA dose-dependent manner. Interestingly, SLC2A13 had a lower effect on Notch processing. Furthermore, overexpression of SLC2A13 increased Abeta40 generation. ...We suggest that SLC2A13 could b …
Silencing of these reduced Abeta secretion in a small interfering RNA dose-dependent manner. Interestingly, SLC2A13 had a lower effec …
An exploratory analysis on gene-environment interactions for Parkinson disease.
Gao J, Nalls MA, Shi M, Joubert BR, Hernandez DG, Huang X, Hollenbeck A, Singleton AB, Chen H. Gao J, et al. Neurobiol Aging. 2012 Oct;33(10):2528.e1-6. doi: 10.1016/j.neurobiolaging.2012.06.007. Epub 2012 Jul 2. Neurobiol Aging. 2012. PMID: 22763023 Free PMC article.
However, with a combined smoking and caffeine intake exposure, we found a significant interaction with rs2896905 at SLC2A13, near LRRK2 (p uncorrected = 0.0008). Each A allele was associated with a 35% higher PD risk among never smokers with low caffeine intake, but with a …
However, with a combined smoking and caffeine intake exposure, we found a significant interaction with rs2896905 at SLC2A13, near LRR …
H+-myo-inositol transporter SLC2A13 as a potential marker for cancer stem cells in an oral squamous cell carcinoma.
Lee DG, Lee JH, Choi BK, Kim MJ, Kim SM, Kim KS, Chang K, Park SH, Bae YS, Kwon BS. Lee DG, et al. Curr Cancer Drug Targets. 2011 Oct;11(8):966-75. doi: 10.2174/156800911797264752. Curr Cancer Drug Targets. 2011. PMID: 21861841
Moreover, SLC2A13 an expression was induced in human breast adenocarcinoma MCF7 cells after serum starvation. Taken together, our results suggest that SLC2A13 can be a potential markers for CSC in various tumors....
Moreover, SLC2A13 an expression was induced in human breast adenocarcinoma MCF7 cells after serum starvation. Taken together, our res …
GLUTs and mammalian sperm metabolism.
Bucci D, Rodriguez-Gil JE, Vallorani C, Spinaci M, Galeati G, Tamanini C. Bucci D, et al. J Androl. 2011 Jul-Aug;32(4):348-55. doi: 10.2164/jandrol.110.011197. Epub 2010 Nov 18. J Androl. 2011. PMID: 21088231 Review.
Identification of genes associated with non-small-cell lung cancer promotion and progression.
Bankovic J, Stojsic J, Jovanovic D, Andjelkovic T, Milinkovic V, Ruzdijic S, Tanic N. Bankovic J, et al. Lung Cancer. 2010 Feb;67(2):151-9. doi: 10.1016/j.lungcan.2009.04.010. Epub 2009 May 26. Lung Cancer. 2010. PMID: 19473719
Obtained sequences were submitted to homology search in GenBank database which revealed the following genes: TSPAN14, CDH12, RDH10, CYP4Z1, KIR, E2F4, PHACTR3, PHF20, PRAME family member and SLC2A13. Following the identification of these genes we examined their relation to …
Obtained sequences were submitted to homology search in GenBank database which revealed the following genes: TSPAN14, CDH12, RDH10, CYP4Z1, …