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Molecular mechanism of SLC5A8 inactivation in breast cancer.
Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M. Elangovan S, et al. Mol Cell Biol. 2013 Oct;33(19):3920-35. doi: 10.1128/MCB.01702-12. Epub 2013 Aug 5. Mol Cell Biol. 2013. PMID: 23918800 Free PMC article.
SLC5A8 is a putative tumor suppressor that is inactivated in more than 10 different types of cancer, but neither the oncogenic signaling responsible for SLC5A8 inactivation nor the functional relevance of SLC5A8 loss to tumor growth has been elucidated. ...Ma …
SLC5A8 is a putative tumor suppressor that is inactivated in more than 10 different types of cancer, but neither the oncogenic signal …
SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.
Thangaraju M, Gopal E, Martin PM, Ananth S, Smith SB, Prasad PD, Sterneck E, Ganapathy V. Thangaraju M, et al. Cancer Res. 2006 Dec 15;66(24):11560-4. doi: 10.1158/0008-5472.CAN-06-1950. Cancer Res. 2006. PMID: 17178845
We found that SLC5A8 is expressed in nontransformed breast epithelial cell lines but silenced by DNA methylation in tumor cell lines. The down-regulation of the gene is also evident in primary breast tumors. When MCF7 breast tumor cells are transfected with SLC5A8 c …
We found that SLC5A8 is expressed in nontransformed breast epithelial cell lines but silenced by DNA methylation in tumor cell lines. …
The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function.
Coothankandaswamy V, Elangovan S, Singh N, Prasad PD, Thangaraju M, Ganapathy V. Coothankandaswamy V, et al. Biochem J. 2013 Feb 15;450(1):169-78. doi: 10.1042/BJ20121248. Biochem J. 2013. PMID: 23167260 Free PMC article.
SLC5A8 (solute carrier gene family 5A, member 8) is a sodium-coupled transporter for monocarboxylates. ...These effects are seen independently of the transport function of SLC5A8 and histone acetylation status of the cell; in the presence of pyruvate, a SLC5A8 …
SLC5A8 (solute carrier gene family 5A, member 8) is a sodium-coupled transporter for monocarboxylates. ...These effects are seen inde …