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Year Number of Results
2005 1
2006 2
2007 2
2008 3
2009 3
2010 1
2011 1
2013 1
2014 1
2015 4
2016 3
2017 3
2019 1
2020 5
2021 2
2022 2
2024 5

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34 results

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Page 1
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension.
Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB. Yung LM, et al. Sci Transl Med. 2020 May 13;12(543):eaaz5660. doi: 10.1126/scitranslmed.aaz5660. Sci Transl Med. 2020. PMID: 32404506 Free PMC article.
By blocking GDF8/11- and activin-mediated SMAD2/3 activation in vascular cells, ACTRIIA-Fc attenuated proliferation of pulmonary arterial smooth muscle cells and pulmonary microvascular endothelial cells. ...ACTRIIA-Fc reveals an unexpectedly pr …
By blocking GDF8/11- and activin-mediated SMAD2/3 activation in vascular cells, ACTRIIA-Fc attenuated proliferation of pulmonary arte …
Sodium tanshinone IIA sulfonate enhances the BMP9-BMPR2-Smad1/5/9 signaling pathway in rat pulmonary microvascular endothelial cells and human embryonic stem cell-derived endothelial cells.
Wang J, Liu W, Lu W, Luo X, Lin Y, Liu S, Qian J, Zhang C, Chen H, Li Y, Li X, Chen J, Chen Y, Jiang Q, Liu C, Hong C, Wang T, Tang H, Zhong N, Yang J, Yang K, Sun D. Wang J, et al. Biochem Pharmacol. 2022 May;199:114986. doi: 10.1016/j.bcp.2022.114986. Epub 2022 Mar 8. Biochem Pharmacol. 2022. PMID: 35276216
METHODS: In this study, we investigated the effects and mechanisms of STS on pulmonary vascular endothelial dysfunction by using a chronic hypoxia-induced pulmonary hypertension (HPH) rat model, as well as in primarily cultured rat PMVECs and human ESC-ECs cell mode …
METHODS: In this study, we investigated the effects and mechanisms of STS on pulmonary vascular endothelial dysfunction by using a ch …
Endothelial Mesenchymal Transition in Hypoxic Microvascular Endothelial Cells and Paracrine Induction of Cardiomyocyte Apoptosis Are Mediated via TGFbeta1/SMAD Signaling.
Sniegon I, Prieß M, Heger J, Schulz R, Euler G. Sniegon I, et al. Int J Mol Sci. 2017 Oct 31;18(11):2290. doi: 10.3390/ijms18112290. Int J Mol Sci. 2017. PMID: 29088068 Free PMC article.
Cardiac remodeling plays a crucial role in the development of heart failure after mycocardial infarction. Besides cardiomyocytes, endothelial cells are recognized to contribute to cardiac remodeling. We now investigated processes of endothelial mesenchymal tr …
Cardiac remodeling plays a crucial role in the development of heart failure after mycocardial infarction. Besides cardiomyocytes, endothe …
Transforming growth factor-beta1 causes pulmonary microvascular endothelial cell apoptosis via ALK5.
Lu Q, Patel B, Harrington EO, Rounds S. Lu Q, et al. Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L825-38. doi: 10.1152/ajplung.90307.2008. Epub 2009 Mar 6. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19270180 Free PMC article.
We have previously shown that transforming growth factor (TGF)-beta1 protected against main pulmonary artery endothelial cell (PAEC) apoptosis induced by serum deprivation and VEGF receptor blockade through a mechanism associated with ALK5-mediated Bcl-2 upregulatio …
We have previously shown that transforming growth factor (TGF)-beta1 protected against main pulmonary artery endothelial cell …
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors.
Al Tabosh T, Liu H, Koça D, Al Tarrass M, Tu L, Giraud S, Delagrange L, Beaudoin M, Rivière S, Grobost V, Rondeau-Lutz M, Dupuis O, Ricard N, Tillet E, Machillot P, Salomon A, Picart C, Battail C, Dupuis-Girod S, Guignabert C, Desroches-Castan A, Bailly S. Al Tabosh T, et al. Angiogenesis. 2024 May;27(2):211-227. doi: 10.1007/s10456-023-09902-8. Epub 2024 Jan 31. Angiogenesis. 2024. PMID: 38294582 Free PMC article.
Here, we aimed to understand the impact of ALK1 mutations on BMP9 and BMP10 transcriptomic responses in endothelial cells. Endothelial colony-forming cells (ECFCs) and microvascular endothelial cells (HMVECs) carrying loss of funct …
Here, we aimed to understand the impact of ALK1 mutations on BMP9 and BMP10 transcriptomic responses in endothelial cells. …
Endothelial cells in co-culture enhance embryonic stem cell differentiation to pancreatic progenitors and insulin-producing cells through BMP signaling.
Talavera-Adame D, Wu G, He Y, Ng TT, Gupta A, Kurtovic S, Hwang JY, Farkas DL, Dafoe DC. Talavera-Adame D, et al. Stem Cell Rev Rep. 2011 Sep;7(3):532-43. doi: 10.1007/s12015-011-9232-z. Stem Cell Rev Rep. 2011. PMID: 21298405 Free PMC article.
Endothelial cells (ECs) represent the major component of the embryonic pancreatic niche and play a key role in the differentiation of insulin-producing beta cells in vivo. ...At EB-EC interface, proinsulin and Nkx6.1 positive cells co-expressed phospho …
Endothelial cells (ECs) represent the major component of the embryonic pancreatic niche and play a key role in the differentia …
High glutamine increases stroke risk by inducing the endothelial-to-mesenchymal transition in moyamoya disease.
He Q, Li J, Tao C, Zeng C, Liu C, Zheng Z, Mou S, Liu W, Zhang B, Yu X, Zhai Y, Wang J, Zhang Q, Zhang Y, Zhang D, Zhao J, Ge P. He Q, et al. MedComm (2020). 2024 Apr 15;5(5):e525. doi: 10.1002/mco2.525. eCollection 2024 May. MedComm (2020). 2024. PMID: 38628905 Free PMC article.
Herein, we aimed to determine the role of glutamine in MMD pathogenesis, and 360 adult patients were prospectively enrolled. Human brain microvascular endothelial cells (HBMECs) were subjected to Integrin Subunit Beta 4 (ITGB4) overexpression or knockdown and …
Herein, we aimed to determine the role of glutamine in MMD pathogenesis, and 360 adult patients were prospectively enrolled. Human brain …
17beta-estradiol promotes angiogenesis through non-genomic activation of Smad1 signaling in endometriosis.
Zhao X, Li X, Liu P, Li P, Xu X, Chen Y, Cheng Y, Zhu D, Fu X. Zhao X, et al. Vascul Pharmacol. 2022 Feb;142:106932. doi: 10.1016/j.vph.2021.106932. Epub 2021 Nov 9. Vascul Pharmacol. 2022. PMID: 34763099
We found that the expression of p-Smad1 was significantly up-regulated in ectopic endometrium and ectopic intima microvascular endothelial cells. ...Moreover, caveolae is involved in E2-induced Smad1 phosphorylation in vascular endothelial …
We found that the expression of p-Smad1 was significantly up-regulated in ectopic endometrium and ectopic intima microvascular …
Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.
Manaud G, Nossent EJ, Lambert M, Ghigna MR, Boët A, Vinhas MC, Ranchoux B, Dumas SJ, Courboulin A, Girerd B, Soubrier F, Bignard J, Claude O, Lecerf F, Hautefort A, Florio M, Sun B, Nadaud S, Verleden SE, Remy S, Anegon I, Bogaard HJ, Mercier O, Fadel E, Simonneau G, Vonk Noordegraaf A, Grünberg K, Humbert M, Montani D, Dorfmüller P, Antigny F, Perros F. Manaud G, et al. Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC. Am J Respir Cell Mol Biol. 2020. PMID: 32209028 Free article.
In human PVOD samples, CHOP immunohistochemical staining mainly labeled endothelial cells in remodeled veins and arteries. Strong HO-1 staining was observed only within capillary hemangiomatosis foci, where intense microvascular proliferation occurs. ...In vi …
In human PVOD samples, CHOP immunohistochemical staining mainly labeled endothelial cells in remodeled veins and arteries. Str …
Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells.
Star GP, Giovinazzo M, Langleben D. Star GP, et al. Vascul Pharmacol. 2009 Jan-Feb;50(1-2):45-50. doi: 10.1016/j.vph.2008.09.001. Epub 2008 Sep 24. Vascul Pharmacol. 2009. PMID: 18849010
BACKGROUND: Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). ...The effects of BMPs and TGF-beta on ET-1 production by human pulmonary microvascular E …
BACKGROUND: Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of h …
34 results