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2005 1
2006 2
2007 2
2008 3
2009 3
2010 1
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2015 4
2016 3
2017 3
2019 1
2020 5
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Page 1
Endothelial Mesenchymal Transition in Hypoxic Microvascular Endothelial Cells and Paracrine Induction of Cardiomyocyte Apoptosis Are Mediated via TGFβ₁/SMAD Signaling.
Sniegon I, Prieß M, Heger J, Schulz R, Euler G. Sniegon I, et al. Int J Mol Sci. 2017 Oct 31;18(11):2290. doi: 10.3390/ijms18112290. Int J Mol Sci. 2017. PMID: 29088068 Free PMC article.
Besides cardiomyocytes, endothelial cells are recognized to contribute to cardiac remodeling. We now investigated processes of endothelial mesenchymal transition (EndoMT) in microvascular endothelial cells of rat (MVEC) under hypoxia and …
Besides cardiomyocytes, endothelial cells are recognized to contribute to cardiac remodeling. We now investigated processes of …
Transforming growth factor-beta1 causes pulmonary microvascular endothelial cell apoptosis via ALK5.
Lu Q, Patel B, Harrington EO, Rounds S. Lu Q, et al. Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L825-38. doi: 10.1152/ajplung.90307.2008. Epub 2009 Mar 6. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19270180 Free PMC article.
In the current study, we investigated the effect of TGF-beta1 on pulmonary microvascular endothelial cell (PMVEC) apoptosis. ...Finally, we noted that SMAD1/5 were activated upon ALK5 inhibition in the presence of low levels of TGF-beta1, an effect ass …
In the current study, we investigated the effect of TGF-beta1 on pulmonary microvascular endothelial cell (PMVEC) apopt …
A Bone Morphogenetic Protein (BMP)-derived Peptide Based on the Type I Receptor-binding Site Modifies Cell-type Dependent BMP Signalling.
Tong Z, Guo J, Glen RC, Morrell NW, Li W. Tong Z, et al. Sci Rep. 2019 Sep 17;9(1):13446. doi: 10.1038/s41598-019-49758-x. Sci Rep. 2019. PMID: 31530856 Free PMC article.
Although showing no baseline activity, P3 significantly enhanced BMP9-induced Smad1/5 phosphorylation as well as ID1, BMPR2, HEY1 and HEY2 gene expression in pulmonary artery endothelial cells (hPAECs), and this activity is dependent on its alpha helix propen …
Although showing no baseline activity, P3 significantly enhanced BMP9-induced Smad1/5 phosphorylation as well as ID1, BMPR2, HEY1 and …
Activation of CD137 Signaling Promotes Angiogenesis in Atherosclerosis via Modulating Endothelial Smad1/5-NFATc1 Pathway.
Weng J, Wang C, Zhong W, Li B, Wang Z, Shao C, Chen Y, Yan J. Weng J, et al. J Am Heart Assoc. 2017 Mar 13;6(3):e004756. doi: 10.1161/JAHA.116.004756. J Am Heart Assoc. 2017. PMID: 28288971 Free PMC article.
Human umbilical vein endothelial cells and mouse brain microvascular endothelial cells were used as in vitro and ex vivo models to study how CD137 signaling affects angiogenesis. ...Activation of CD137 signaling induced angiogenesis, endothel
Human umbilical vein endothelial cells and mouse brain microvascular endothelial cells were used as in vi …
Endothelial cells in co-culture enhance embryonic stem cell differentiation to pancreatic progenitors and insulin-producing cells through BMP signaling.
Talavera-Adame D, Wu G, He Y, Ng TT, Gupta A, Kurtovic S, Hwang JY, Farkas DL, Dafoe DC. Talavera-Adame D, et al. Stem Cell Rev Rep. 2011 Sep;7(3):532-43. doi: 10.1007/s12015-011-9232-z. Stem Cell Rev Rep. 2011. PMID: 21298405 Free PMC article.
Endothelial cells (ECs) represent the major component of the embryonic pancreatic niche and play a key role in the differentiation of insulin-producing β cells in vivo. ...At EB-EC interface, proinsulin and Nkx6.1 positive cells co-expressed phospho-
Endothelial cells (ECs) represent the major component of the embryonic pancreatic niche and play a key role in the differentia
Ionizing radiation shifts the PAI-1/ID-1 balance and activates notch signaling in endothelial cells.
Scharpfenecker M, Kruse JJ, Sprong D, Russell NS, Ten Dijke P, Stewart FA. Scharpfenecker M, et al. Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):506-13. doi: 10.1016/j.ijrobp.2008.09.052. Int J Radiat Oncol Biol Phys. 2009. PMID: 19147015
To investigate the mechanism of such capillary damage, we studied the effect of TGF-beta and Notch signaling in microvascular endothelial cells. METHODS AND MATERIALS: Human microvascular endothelial cells were irradiated with 5 or 10 Gy …
To investigate the mechanism of such capillary damage, we studied the effect of TGF-beta and Notch signaling in microvascular endo
Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.
Manaud G, Nossent EJ, Lambert M, Ghigna MR, Boët A, Vinhas MC, Ranchoux B, Dumas SJ, Courboulin A, Girerd B, Soubrier F, Bignard J, Claude O, Lecerf F, Hautefort A, Florio M, Sun B, Nadaud S, Verleden SE, Remy S, Anegon I, Bogaard HJ, Mercier O, Fadel E, Simonneau G, Vonk Noordegraaf A, Grünberg K, Humbert M, Montani D, Dorfmüller P, Antigny F, Perros F. Manaud G, et al. Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC. Am J Respir Cell Mol Biol. 2020. PMID: 32209028
In human PVOD samples, CHOP immunohistochemical staining mainly labeled endothelial cells in remodeled veins and arteries. Strong HO-1 staining was observed only within capillary hemangiomatosis foci, where intense microvascular proliferation occurs. ...In vi …
In human PVOD samples, CHOP immunohistochemical staining mainly labeled endothelial cells in remodeled veins and arteries. Str …
Tetramethylpyrazine inhibits tumor growth of lung cancer through disrupting angiogenesis via BMP/Smad/Id-1 signaling.
Jia Y, Wang Z, Zang A, Jiao S, Chen S, Fu Y. Jia Y, et al. Int J Oncol. 2016 May;48(5):2079-86. doi: 10.3892/ijo.2016.3443. Epub 2016 Mar 15. Int J Oncol. 2016. PMID: 26984046
In vitro cell proliferation, migration, and tube formation of human microvascular endothelial cells (HMEC-1) were evaluated by a 3-(4,5-dimethylthiazol-2-yl)-2,5-dephenyltetrazolium bromide (MTT), wound healing, Transwell, and Matrigel assays. ...Furth …
In vitro cell proliferation, migration, and tube formation of human microvascular endothelial cells (HMEC-1) wer …
Functional characterization of bone morphogenetic protein binding sites and Smad1/5 activation in human vascular cells.
Upton PD, Long L, Trembath RC, Morrell NW. Upton PD, et al. Mol Pharmacol. 2008 Feb;73(2):539-52. doi: 10.1124/mol.107.041673. Epub 2007 Nov 7. Mol Pharmacol. 2008. PMID: 17989347
However, the specific receptors mediating responses to BMPs in human vascular cells are not known. We show that human pulmonary artery smooth muscle cells (HPASMCs) express high specific (125)I-BMP4 binding, whereas human microvascular endothelial c
However, the specific receptors mediating responses to BMPs in human vascular cells are not known. We show that human pulmonary arter …
BAMBI elimination enhances alternative TGF-β signaling and glomerular dysfunction in diabetic mice.
Fan Y, Li X, Xiao W, Fu J, Harris RC, Lindenmeyer M, Cohen CD, Guillot N, Baron MH, Wang N, Lee K, He JC, Schlondorff D, Chuang PY. Fan Y, et al. Diabetes. 2015 Jun;64(6):2220-33. doi: 10.2337/db14-1397. Epub 2015 Jan 9. Diabetes. 2015. PMID: 25576053 Free PMC article.
Because diabetic glomerular disease is associated with TGF-β overexpression and microvascular alterations, we examined the effect of diabetes on glomerular BAMBI mRNA levels. ...The downregulation of Vegfr2 in diabetes was localized to glomerular endothelial cell
Because diabetic glomerular disease is associated with TGF-β overexpression and microvascular alterations, we examined the effect of …
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