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Did you mean mn complex (31,246 results)?
The SMN Complex at the Crossroad between RNA Metabolism and Neurodegeneration.
Faravelli I, Riboldi GM, Rinchetti P, Lotti F. Faravelli I, et al. Int J Mol Sci. 2023 Jan 23;24(3):2247. doi: 10.3390/ijms24032247. Int J Mol Sci. 2023. PMID: 36768569 Free PMC article. Review.
In the cell, RNA exists and functions in a complex with RNA binding proteins (RBPs) that regulate each step of the RNA life cycle from transcription to degradation. ...Recent clarification of the central role of the SMN complex in RNA metabolism and a …
In the cell, RNA exists and functions in a complex with RNA binding proteins (RBPs) that regulate each step of the RNA life cy …
The SMN complex.
Gubitz AK, Feng W, Dreyfuss G. Gubitz AK, et al. Exp Cell Res. 2004 May 15;296(1):51-6. doi: 10.1016/j.yexcr.2004.03.022. Exp Cell Res. 2004. PMID: 15120993 Review.
The SMN complex contains, in addition to SMN, at least six other proteins, named Gemins2-7, and plays an essential role in the assembly of the spliceosomal small nuclear ribonucleoproteins (snRNPs). Through its binding to specific sequences in the snRN …
The SMN complex contains, in addition to SMN, at least six other proteins, named Gemins2-7, and plays an essenti …
The SMN complex, an assemblyosome of ribonucleoproteins.
Paushkin S, Gubitz AK, Massenet S, Dreyfuss G. Paushkin S, et al. Curr Opin Cell Biol. 2002 Jun;14(3):305-12. doi: 10.1016/s0955-0674(02)00332-0. Curr Opin Cell Biol. 2002. PMID: 12067652 Review.
Spinal muscular atrophy is a common, often lethal, neurodegenerative disease that results from low levels of, or loss-of-function mutations in, the SMN (survival of motor neurons) protein. SMN oligomerizes and forms a stable complex with five additional pr …
Spinal muscular atrophy is a common, often lethal, neurodegenerative disease that results from low levels of, or loss-of-function mutations …
The SMN complex: an assembly machine for RNPs.
Battle DJ, Kasim M, Yong J, Lotti F, Lau CK, Mouaikel J, Zhang Z, Han K, Wan L, Dreyfuss G. Battle DJ, et al. Cold Spring Harb Symp Quant Biol. 2006;71:313-20. doi: 10.1101/sqb.2006.71.001. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381311 Review.
In eukaryotic cells, the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and likely other RNPs is mediated by an assemblyosome, the survival of motor neurons (SMN) complex. The SMN complex, composed of SMN and the Gemins (2- …
In eukaryotic cells, the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and likely other RNPs is mediated by an assemb …
Molecular functions of the SMN complex.
Kolb SJ, Battle DJ, Dreyfuss G. Kolb SJ, et al. J Child Neurol. 2007 Aug;22(8):990-4. doi: 10.1177/0883073807305666. J Child Neurol. 2007. PMID: 17761654 Review.
Specifically, the SMN complex assembles 7 Sm proteins into a core structure around a highly conserved sequence of ribonucleic acid (RNA) found in small nuclear RNAs. ...In addition to the SMN protein, the SMN complex contains 7 additional …
Specifically, the SMN complex assembles 7 Sm proteins into a core structure around a highly conserved sequence of ribon …
Sumoylation regulates the assembly and activity of the SMN complex.
Riboldi GM, Faravelli I, Kuwajima T, Delestrée N, Dermentzaki G, De Planell-Saguer M, Rinchetti P, Hao LT, Beattie CC, Corti S, Przedborski S, Mentis GZ, Lotti F. Riboldi GM, et al. Nat Commun. 2021 Aug 19;12(1):5040. doi: 10.1038/s41467-021-25272-5. Nat Commun. 2021. PMID: 34413305 Free PMC article.
SMN interacts with itself and other proteins to form a complex that functions in the assembly of ribonucleoproteins. ...These findings suggest that sumoylation is important for proper assembly and function of the SMN complex and that loss of thi …
SMN interacts with itself and other proteins to form a complex that functions in the assembly of ribonucleoproteins. .. …
Interaction of 7SK with the Smn complex modulates snRNP production.
Ji C, Bader J, Ramanathan P, Hennlein L, Meissner F, Jablonka S, Mann M, Fischer U, Sendtner M, Briese M. Ji C, et al. Nat Commun. 2021 Feb 24;12(1):1278. doi: 10.1038/s41467-021-21529-1. Nat Commun. 2021. PMID: 33627647 Free PMC article.
While the interplay between transcription kinetics and spliceosome fidelity has been investigated before, less is known about mechanisms regulating the assembly of the spliceosomal machinery in response to transcription changes. Here, we report an association of the Smn …
While the interplay between transcription kinetics and spliceosome fidelity has been investigated before, less is known about mechanisms reg …
Phosphoregulation of the human SMN complex.
Husedzinovic A, Oppermann F, Draeger-Meurer S, Chari A, Fischer U, Daub H, Gruss OJ. Husedzinovic A, et al. Eur J Cell Biol. 2014 Mar;93(3):106-17. doi: 10.1016/j.ejcb.2014.01.006. Epub 2014 Feb 11. Eur J Cell Biol. 2014. PMID: 24602413
The survival motor neuron (SMN) complex is a macromolecular machine comprising 9 core proteins: SMN, Gemins2-8 and unrip in vertebrates. ...The SMN complex is subject to extensive phosphorylation. Detailed understanding of SMN c …
The survival motor neuron (SMN) complex is a macromolecular machine comprising 9 core proteins: SMN, Gemins2-8 a …
The SMN complex drives structural changes in human snRNAs to enable snRNP assembly.
Pánek J, Roithová A, Radivojević N, Sýkora M, Prusty AB, Huston N, Wan H, Pyle AM, Fischer U, Staněk D. Pánek J, et al. Nat Commun. 2023 Oct 18;14(1):6580. doi: 10.1038/s41467-023-42324-0. Nat Commun. 2023. PMID: 37852981 Free PMC article.
Spliceosomal snRNPs are multicomponent particles that undergo a complex maturation pathway. Human Sm-class snRNAs are generated as 3'-end extended precursors, which are exported to the cytoplasm and assembled together with Sm proteins into core RNPs by the SMN …
Spliceosomal snRNPs are multicomponent particles that undergo a complex maturation pathway. Human Sm-class snRNAs are generated as 3' …
Identification and structural analysis of the Schizosaccharomyces pombe SMN complex.
Veepaschit J, Viswanathan A, Bordonné R, Grimm C, Fischer U. Veepaschit J, et al. Nucleic Acids Res. 2021 Jul 21;49(13):7207-7223. doi: 10.1093/nar/gkab158. Nucleic Acids Res. 2021. PMID: 33754639 Free PMC article.
While biochemical studies have revealed key activities of the SMN complex, its structural investigation is lagging behind. Here we report on the identification and structural determination of the SMN complex from the lower eukaryote Schizosaccharomyces …
While biochemical studies have revealed key activities of the SMN complex, its structural investigation is lagging behind. Her …
2,605 results