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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 10
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1997 43
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2000 84
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2002 100
2003 119
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2005 163
2006 201
2007 199
2008 191
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5,644 results

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Page 1
SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology: New and Renascent Themes.
Bunton-Stasyshyn RK, Saccon RA, Fratta P, Fisher EM. Bunton-Stasyshyn RK, et al. Neuroscientist. 2015 Oct;21(5):519-29. doi: 10.1177/1073858414561795. Epub 2014 Dec 9. Neuroscientist. 2015. PMID: 25492944 Free article. Review.
The canonical role of superoxide dismutase 1 (SOD1) is as an antioxidant enzyme protecting the cell from reactive oxygen species toxicity. SOD1 was also the first gene in which mutations were found to be causative for the neurodegenerative disease amyotrophic …
The canonical role of superoxide dismutase 1 (SOD1) is as an antioxidant enzyme protecting the cell from reactive oxygen species toxi …
Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS).
Abati E, Bresolin N, Comi G, Corti S. Abati E, et al. Expert Opin Ther Targets. 2020 Apr;24(4):295-310. doi: 10.1080/14728222.2020.1738390. Epub 2020 Mar 14. Expert Opin Ther Targets. 2020. PMID: 32125907 Free article. Review.
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disorder that targets upper and lower motor neurons and leads to fatal muscle paralysis. ...SOD1 induces numerous toxic effects through the pathological …
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disorder that target …
SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity.
Berdyński M, Miszta P, Safranow K, Andersen PM, Morita M, Filipek S, Żekanowski C, Kuźma-Kozakiewicz M. Berdyński M, et al. Sci Rep. 2022 Jan 7;12(1):103. doi: 10.1038/s41598-021-03891-8. Sci Rep. 2022. PMID: 34996976 Free PMC article.
Mutations in superoxide dismutase 1 gene (SOD1) are linked to amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder predominantly affecting upper and lower motor neurons. ...The aim of the study was to analyze the relations between individu …
Mutations in superoxide dismutase 1 gene (SOD1) are linked to amyotrophic lateral sclerosis (ALS), a neurodegene …
Variability in SOD1-associated amyotrophic lateral sclerosis: geographic patterns, clinical heterogeneity, molecular alterations, and therapeutic implications.
Huang M, Liu YU, Yao X, Qin D, Su H. Huang M, et al. Transl Neurodegener. 2024 May 29;13(1):28. doi: 10.1186/s40035-024-00416-x. Transl Neurodegener. 2024. PMID: 38811997 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons, resulting in global health burden and limited post-diagnosis life expectancy. ...Gain of function of toxic aggregates of SOD1 r …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neu …
SOD1 in Amyotrophic Lateral Sclerosis: "Ambivalent" Behavior Connected to the Disease.
Pansarasa O, Bordoni M, Diamanti L, Sproviero D, Gagliardi S, Cereda C. Pansarasa O, et al. Int J Mol Sci. 2018 May 3;19(5):1345. doi: 10.3390/ijms19051345. Int J Mol Sci. 2018. PMID: 29751510 Free PMC article. Review.
In 1993, Rosen and collaborators discovered that the gene encoding SOD1 has mutations in amyotrophic lateral sclerosis (ALS) patients; moreover, these mutations are found in the exon regions, suggesting that their toxic effects are the consequence of p …
In 1993, Rosen and collaborators discovered that the gene encoding SOD1 has mutations in amyotrophic lateral scleros …
Antisense oligonucleotide therapy in amyotrophic lateral sclerosis.
Erdi-Krausz G, Shaw PJ. Erdi-Krausz G, et al. Curr Opin Neurol. 2025 Oct 1;38(5):574-580. doi: 10.1097/WCO.0000000000001413. Epub 2025 Aug 20. Curr Opin Neurol. 2025. PMID: 40832750 Free article. Review.
PURPOSE OF REVIEW: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with few treatment options available. ...SUMMARY: ASO therapies have made some promising steps towards treating familial ALS, particularly SOD1 . Ongoing early …
PURPOSE OF REVIEW: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with few treatment options …
Updates on Disease Mechanisms and Therapeutics for Amyotrophic Lateral Sclerosis.
Nguyen L. Nguyen L. Cells. 2024 May 21;13(11):888. doi: 10.3390/cells13110888. Cells. 2024. PMID: 38891021 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a motor neuron disease. ...Several highlighted ALS research topics discussed in this article include the 2023 FDA approved drug for SOD1 ALS, the updated C9orf72 GGGGCC repeat-expansion-r …
Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a motor neuron disease. ...Several highlighted ALS res …
Comparison between PFN1 and SOD1 mutations in amyotrophic lateral sclerosis.
Corcia P, Lejeune P, Vourc'h P, Beltran S, Piegay AS, Blasco H, Meininger V. Corcia P, et al. Eur J Neurol. 2023 Feb;30(2):552-554. doi: 10.1111/ene.15583. Epub 2022 Oct 18. Eur J Neurol. 2023. PMID: 36176198 Review.
BACKGROUND: The objective of this study was to characterize the prototypical phenotype of patients with amyotrophic lateral sclerosis (ALS) associated with PFN1 mutations in profilin 1 (PFN1) and to determine clinical indications to test for mutations in this …
BACKGROUND: The objective of this study was to characterize the prototypical phenotype of patients with amyotrophic lateral …
Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis.
Kaur SJ, McKeown SR, Rashid S. Kaur SJ, et al. Gene. 2016 Feb 15;577(2):109-18. doi: 10.1016/j.gene.2015.11.049. Epub 2015 Dec 2. Gene. 2016. PMID: 26657039 Review.
Amyotrophic lateral sclerosis (ALS) is a neural disorder that causes death of the motor neurons in the brain and spinal cord; this affects the voluntary muscles and gradually leads to paralysis of the whole body. ...The enzyme binds both copper and zinc ions …
Amyotrophic lateral sclerosis (ALS) is a neural disorder that causes death of the motor neurons in the brain and spinal …
Tofersen for SOD1 ALS.
Everett WH, Bucelli RC. Everett WH, et al. Neurodegener Dis Manag. 2024;14(5):149-160. doi: 10.1080/17582024.2024.2402216. Epub 2024 Sep 27. Neurodegener Dis Manag. 2024. PMID: 39330700 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition affecting the motor system. ...Tofersen is a recently approved medication that acts by reducing a toxic protein found in a particular form of inherited amyotrophic lateral s …
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition affecting the motor system. ...Tofersen is a recen …
5,644 results