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2007 6
2008 5
2009 4
2010 5
2011 2
2012 3
2013 6
2014 6
2015 8
2016 11
2017 9
2018 4
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2020 2
2021 5
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74 results

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Page 1
Alzheimer's disease risk genes and mechanisms of disease pathogenesis.
Karch CM, Goate AM. Karch CM, et al. Biol Psychiatry. 2015 Jan 1;77(1):43-51. doi: 10.1016/j.biopsych.2014.05.006. Epub 2014 May 17. Biol Psychiatry. 2015. PMID: 24951455 Free PMC article. Review.
We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in AD pathogenesis. ...We review the relationship between these AD risk genes and the cellular and neuropathologic features of AD. Understanding the …
We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in AD pa …
SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease.
Wen Y, Miyashita A, Kitamura N, Tsukie T, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Akatsu H, Yamamoto T, Kosaka K, Yamaguchi H, Akazawa K, Ihara Y, Kuwano R. Wen Y, et al. J Alzheimers Dis. 2013;35(2):387-94. doi: 10.3233/JAD-122395. J Alzheimers Dis. 2013. PMID: 23455993
SORL1 was shown to be genetically associated with late-onset Alzheimer's disease (LOAD) in a large-scale genome-wide association study (GWAS) involving clinically verified subjects. ...Our replication study strongly s …
SORL1 was shown to be genetically associated with late-onset Alzheimer's disease (LO …
SORL1 Is Associated with the Risk of Late-Onset Alzheimer's Disease: a Replication Study and Meta-Analyses.
Zhang CC, Wang HF, Tan MS, Wan Y, Zhang W, Zheng ZJ, Kong LL, Wang ZX, Tan L, Jiang T, Tan L, Yu JT. Zhang CC, et al. Mol Neurobiol. 2017 Apr;54(3):1725-1732. doi: 10.1007/s12035-016-9780-y. Epub 2016 Feb 13. Mol Neurobiol. 2017. PMID: 26873856
The sorting-related receptor gene (SORL1) has been defined as an interesting candidate gene for Alzheimer's disease (AD). Recently, one novel variant, rs11218343, within SORL1 was reported to be related to late-onset Alzheimer …
The sorting-related receptor gene (SORL1) has been defined as an interesting candidate gene for Alzheimer's disease …
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I; Alzheimer Disease Genetics Consortium; St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R. Miyashita A, et al. PLoS One. 2013;8(4):e58618. doi: 10.1371/journal.pone.0058618. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565137 Free PMC article.
To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer D …
To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome- …
SORL1 mutations in early- and late-onset Alzheimer disease.
Cuccaro ML, Carney RM, Zhang Y, Bohm C, Kunkle BW, Vardarajan BN, Whitehead PL, Cukier HN, Mayeux R, St George-Hyslop P, Pericak-Vance MA. Cuccaro ML, et al. Neurol Genet. 2016 Oct 26;2(6):e116. doi: 10.1212/NXG.0000000000000116. eCollection 2016 Dec. Neurol Genet. 2016. PMID: 27822510 Free PMC article.
OBJECTIVE: To characterize the clinical and molecular effect of mutations in the sortilin-related receptor (SORL1) gene. METHODS: We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer dise …
OBJECTIVE: To characterize the clinical and molecular effect of mutations in the sortilin-related receptor (SORL1) gene. METHODS: We …
SORL1 gene polymorphism association with late-onset Alzheimer's disease.
Feng X, Hou D, Deng Y, Li W, Tian M, Yu Z. Feng X, et al. Neurosci Lett. 2015 Jan 1;584:382-9. doi: 10.1016/j.neulet.2014.10.055. Epub 2014 Nov 4. Neurosci Lett. 2015. PMID: 25450149
We examined the relationship between loci polymorphisms (rs689021, rs3824966, and rs1784933) of the sortilin-related receptor 1 gene (SORL1) and late-onset Alzheimer's disease (LOAD) in the Chinese Han population of the Hunan Changsha reg …
We examined the relationship between loci polymorphisms (rs689021, rs3824966, and rs1784933) of the sortilin-related receptor 1 gene (SOR …
The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.
Lee JH, Barral S, Reitz C. Lee JH, et al. Curr Neurol Neurosci Rep. 2008 Sep;8(5):384-91. doi: 10.1007/s11910-008-0060-8. Curr Neurol Neurosci Rep. 2008. PMID: 18713574 Free PMC article. Review.
Recent studies indicate that two clusters of single nucleotide polymorphisms in the neuronal sortilin-related receptor gene (SORL1) are causally associated with late-onset Alzheimer's disease (AD). ...Furthermore, several geneti …
Recent studies indicate that two clusters of single nucleotide polymorphisms in the neuronal sortilin-related receptor gene (SORL1) a …
Molecular Genetics of Early- and Late-Onset Alzheimer's Disease.
Uddin MS, Hasana S, Hossain MF, Islam MS, Behl T, Perveen A, Hafeez A, Ashraf GM. Uddin MS, et al. Curr Gene Ther. 2021;21(1):43-52. doi: 10.2174/1566523220666201123112822. Curr Gene Ther. 2021. PMID: 33231156 Review.
Alzheimer's disease (AD) is the most common form of dementia in the elderly and this complex disorder is associated with environmental as well as genetic factors. Early-onset AD (EOAD) and late-onset AD (LOAD, more common) are majo …
Alzheimer's disease (AD) is the most common form of dementia in the elderly and this complex disorder is associated …
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.
Bettens K, Brouwers N, Engelborghs S, De Deyn PP, Van Broeckhoven C, Sleegers K. Bettens K, et al. Hum Mutat. 2008 May;29(5):769-70. doi: 10.1002/humu.20725. Hum Mutat. 2008. PMID: 18407551
SORL1 has recently been identified as a major genetic contributor to increased risk for late-onset Alzheimer disease (AD). ...Two signals in distinct regions of the gene were shown to be mutually independent, supporting allelic heterogene …
SORL1 has recently been identified as a major genetic contributor to increased risk for late-onset Alzheimer …
SORL1 Polymorphisms in Mexican Patients with Alzheimer's Disease.
Toral-Rios D, Ruiz-Sánchez E, Rodríguez NLM, Maury-Rosillo M, Rosas-Carrasco Ó, Becerril-Pérez F, Mena-Barranco F, Carvajal-García R, Silva-Adaya D, Delgado-Namorado Y, Ramos-Palacios G, Sánchez-Torres C, Campos-Peña V. Toral-Rios D, et al. Genes (Basel). 2022 Mar 25;13(4):587. doi: 10.3390/genes13040587. Genes (Basel). 2022. PMID: 35456392 Free PMC article.
The present study evaluated the risk effect of 12 Single Nucleotide Polymorphisms in the SORL1 gene in the Mexican population using Late-Onset Alzheimer's Disease (LOAD) and control subjects. ...Future molecular studies could help underst …
The present study evaluated the risk effect of 12 Single Nucleotide Polymorphisms in the SORL1 gene in the Mexican population using …
74 results