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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 4
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2000 6
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2002 15
2003 5
2004 9
2005 7
2006 9
2007 22
2008 27
2009 32
2010 35
2011 25
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815 results

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Page 1
CycC1;1-WRKY75 complex-mediated transcriptional regulation of SOS1 controls salt stress tolerance in Arabidopsis.
Lu KK, Song RF, Guo JX, Zhang Y, Zuo JX, Chen HH, Liao CY, Hu XY, Ren F, Lu YT, Liu WC. Lu KK, et al. Plant Cell. 2023 Jun 26;35(7):2570-2591. doi: 10.1093/plcell/koad105. Plant Cell. 2023. PMID: 37040621 Free PMC article.
SALT OVERLY SENSITIVE1 (SOS1) is a key component of plant salt tolerance. However, how SOS1 transcription is dynamically regulated in plant response to different salinity conditions remains elusive. ...Enhanced salt tolerance of the cycc1;1 mutant was completely com …
SALT OVERLY SENSITIVE1 (SOS1) is a key component of plant salt tolerance. However, how SOS1 transcription is dynamically regul …
SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations.
Lepri F, De Luca A, Stella L, Rossi C, Baldassarre G, Pantaleoni F, Cordeddu V, Williams BJ, Dentici ML, Caputo V, Venanzi S, Bonaguro M, Kavamura I, Faienza MF, Pilotta A, Stanzial F, Faravelli F, Gabrielli O, Marino B, Neri G, Silengo MC, Ferrero GB, Torrrente I, Selicorni A, Mazzanti L, Digilio MC, Zampino G, Dallapiccola B, Gelb BD, Tartaglia M. Lepri F, et al. Hum Mutat. 2011 Jul;32(7):760-72. doi: 10.1002/humu.21492. Epub 2011 Apr 28. Hum Mutat. 2011. PMID: 21387466 Free PMC article.
NS is caused by aberrant RAS-MAPK signaling and is genetically heterogeneous, which explains, in part, the marked clinical variability documented for this Mendelian trait. Recently, we and others identified SOS1 as a major gene underlying NS. Here, we explored furth …
NS is caused by aberrant RAS-MAPK signaling and is genetically heterogeneous, which explains, in part, the marked clinical variability docum …
Noonan syndrome and clinically related disorders.
Tartaglia M, Gelb BD, Zenker M. Tartaglia M, et al. Best Pract Res Clin Endocrinol Metab. 2011 Feb;25(1):161-79. doi: 10.1016/j.beem.2010.09.002. Best Pract Res Clin Endocrinol Metab. 2011. PMID: 21396583 Free PMC article. Review.
Noonan syndrome is transmitted as an autosomal dominant trait, and is genetically heterogeneous. So far, heterozygous mutations in nine genes (PTPN11, SOS1, KRAS, NRAS, RAF1, BRAF, SHOC2, MEK1 and CBL) have been documented to underlie this disorder or clinically rel …
Noonan syndrome is transmitted as an autosomal dominant trait, and is genetically heterogeneous. So far, heterozygous mutations in nine g …
Targeting RAS oncogenesis with SOS1 inhibitors.
Hillig RC, Bader B. Hillig RC, et al. Adv Cancer Res. 2022;153:169-203. doi: 10.1016/bs.acr.2021.07.001. Epub 2021 Sep 15. Adv Cancer Res. 2022. PMID: 35101230 Review.
As an alternative approach, inhibitors for the RAS guanine nucleotide exchange factor SOS1 have been investigated by several academic groups and companies, and major progress has been achieved in recent years in the optimization of small molecule activators and inhibitors …
As an alternative approach, inhibitors for the RAS guanine nucleotide exchange factor SOS1 have been investigated by several academic …
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B. Hillig RC, et al. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25. Proc Natl Acad Sci U S A. 2019. PMID: 30683722 Free PMC article.
Since the late 1980s, mutations in the RAS genes have been recognized as major oncogenes with a high occurrence rate in human cancers. ...Here, we describe the identification of potent and cell-active small-molecule inhibitors which efficiently disrupt the interaction betw …
Since the late 1980s, mutations in the RAS genes have been recognized as major oncogenes with a high occurrence rate in human cancers …
Comparative assessment of gene-specific variant distribution in prenatal and postnatal cohorts tested for Noonan syndrome and related conditions.
Leach NT, Wilson Mathews DR, Rosenblum LS, Zhou Z, Zhu H, Heim RA. Leach NT, et al. Genet Med. 2019 Feb;21(2):417-425. doi: 10.1038/s41436-018-0062-0. Epub 2018 Jun 15. Genet Med. 2019. PMID: 29907801 Free article.
PURPOSE: To compare the pattern of gene-specific involvement and the spectrum of variants observed in prenatal and postnatal (mean SD, 8.9 9.4 years) cohorts tested for Noonan syndrome and related conditions. ...PTPN11 and SOS1 had a 1.5-fold higher VUS frequency in …
PURPOSE: To compare the pattern of gene-specific involvement and the spectrum of variants observed in prenatal and postnatal (mean SD …
SOS1 gene family in mangrove (Kandelia obovata): Genome-wide identification, characterization, and expression analyses under salt and copper stress.
Shang C, Sihui L, Li C, Hussain Q, Chen P, Hussain MA, Nkoh Nkoh J. Shang C, et al. BMC Plant Biol. 2024 Aug 27;24(1):805. doi: 10.1186/s12870-024-05528-0. BMC Plant Biol. 2024. PMID: 39187766 Free PMC article.
RESULTS: A genome-wide analysis and bioinformatics techniques were used in this study to identify 20 SOS1 genes in the genome of Kandelia obovata. Most of the SOS1 genes were found on the plasma membrane and dispersed over 11 of the 18 chromosomes. ... …
RESULTS: A genome-wide analysis and bioinformatics techniques were used in this study to identify 20 SOS1 genes in the genome …
SOS1 gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population: Results from a nested case-control study in Taiyuan, China.
Chen Q, Yang H, Feng Y, Zhang P, Wu W, Li S, Thompson B, Wang X, Peng T, Wang F, Xie B, Guo P, Li M, Wang Y, Zhao N, Wang S, Zhang Y. Chen Q, et al. Diab Vasc Dis Res. 2018 Mar;15(2):158-161. doi: 10.1177/1479164117745260. Epub 2017 Dec 13. Diab Vasc Dis Res. 2018. PMID: 29233017 Free article.
At the gene level, SOS1 was statistically significantly associated with gestational diabetes mellitus risk after adjusting for multiple comparisons. Moreover, AGGA and GGGG haplotypes in SOS1 gene were associated with reduced risk of gestational diabet …
At the gene level, SOS1 was statistically significantly associated with gestational diabetes mellitus risk after adjusting for …
SOS1 and halophytism.
Oh DH, Zahir A, Yun DJ, Bressan RA, Bohnert HJ. Oh DH, et al. Plant Signal Behav. 2009 Nov;4(11):1081-3. doi: 10.4161/psb.4.11.9786. Epub 2009 Nov 11. Plant Signal Behav. 2009. PMID: 19838069 Free PMC article.
Much is already known about the function and functioning of the three genes that make up the SOS (Salt-Overly-Sensitive) pathway in plants, but recent studies indicate that the linkage between external increases in salinity and stress protection provided by genes …
Much is already known about the function and functioning of the three genes that make up the SOS (Salt-Overly-Sensitive) pathway in p …
Genome-wide characterization of SOS1 gene family in potato (Solanum tuberosum) and expression analyses under salt and hormone stress.
Liang L, Guo L, Zhai Y, Hou Z, Wu W, Zhang X, Wu Y, Liu X, Guo S, Gao G, Liu W. Liang L, et al. Front Plant Sci. 2023 Jun 30;14:1201730. doi: 10.3389/fpls.2023.1201730. eCollection 2023. Front Plant Sci. 2023. PMID: 37457336 Free PMC article.
Salt Overly Sensitive 1 (SOS1) is one of the members of the Salt Overly Sensitive (SOS) signaling pathway and plays critical salt tolerance determinant in plants, while the characterization of the SOS1 family in potato (Solanum tuberosum) is lacking. ...These result …
Salt Overly Sensitive 1 (SOS1) is one of the members of the Salt Overly Sensitive (SOS) signaling pathway and plays critical salt tol …
815 results