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Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells.
Pong S, Lizano P, Karmacharya R. Pong S, et al. J Vis Exp. 2020 Nov 19;(165). doi: 10.3791/61629. J Vis Exp. 2020. PMID: 33283783
Brain microvascular endothelial cells (BMECs) can be differentiated from human induced pluripotent stem cells (iPSCs) to develop ex vivo cellular models for studying blood-brain barrier (BBB) function. ...Successful derivation of BMECs is confirmed by …
Brain microvascular endothelial cells (BMECs) can be differentiated from human induced pluripotent stem cells (i …
Quantitative Proteomics Analysis of Ischemia/Reperfusion Injury-Modulated Proteins in Cardiac Microvascular Endothelial Cells and the Protective Role of Tongxinluo.
Li Q, Cui HH, Yang YJ, Li XD, Chen GH, Tian XQ, Jin C, Dong QT, Huang PS, Xu J. Li Q, et al. Cell Physiol Biochem. 2017;41(4):1503-1518. doi: 10.1159/000470806. Epub 2017 Mar 24. Cell Physiol Biochem. 2017. PMID: 28334711 Free article.
BACKGROUND: The protection of endothelial cells (ECs) against reperfusion injury has received little attention. In this study, we used Tandem Mass Tag (TMT) labeling proteomics to investigate the modulated proteins in an in vitro model of cardiac microvascular
BACKGROUND: The protection of endothelial cells (ECs) against reperfusion injury has received little attention. In this study, …
Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations.
Zhang L, Gao S, White Z, Dai Y, Malik AB, Rehman J. Zhang L, et al. JCI Insight. 2022 May 5:e158079. doi: 10.1172/jci.insight.158079. Online ahead of print. JCI Insight. 2022. PMID: 35511435 Free article.
Studies have demonstrated the phenotypic heterogeneity of vascular endothelial cells (ECs) within a vascular bed; however, little is known about how distinct endothelial subpopulations in a particular organ respond to an inflammatory stimulus. ...Following th …
Studies have demonstrated the phenotypic heterogeneity of vascular endothelial cells (ECs) within a vascular bed; however, lit …
Developmental regulation of barrier- and non-barrier blood vessels in the CNS.
Ben-Zvi A, Liebner S. Ben-Zvi A, et al. J Intern Med. 2021 Mar 4. doi: 10.1111/joim.13263. Online ahead of print. J Intern Med. 2021. PMID: 33665890
The blood-brain barrier (BBB) is essential for creating and maintaining tissue homeostasis in the central nervous system (CNS), which is key for proper neuronal function. In most vertebrates, the BBB is localized to microvascular endothelial cells that acquir …
The blood-brain barrier (BBB) is essential for creating and maintaining tissue homeostasis in the central nervous system (CNS), which is key …
Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.
Saba R, Kitajima K, Rainbow L, Engert S, Uemura M, Ishida H, Kokkinopoulos I, Shintani Y, Miyagawa S, Kanai Y, Kanai-Azuma M, Koopman P, Meno C, Kenny J, Lickert H, Saga Y, Suzuki K, Sawa Y, Yashiro K. Saba R, et al. Sci Rep. 2019 Aug 16;9(1):11953. doi: 10.1038/s41598-019-48321-y. Sci Rep. 2019. PMID: 31420575 Free PMC article.
Deletion of Sox17 specifically in the mesoderm markedly impaired endocardium development with regard to cell proliferation and behavior. The proliferation of cardiomyocytes, ventricular trabeculation, and myocardium thickening were also impaired in a non-cell
Deletion of Sox17 specifically in the mesoderm markedly impaired endocardium development with regard to cell proliferation and …