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631 results

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Page 1
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation.
Jing Y, Jiang X, Ji Q, Wu Z, Wang W, Liu Z, Guillen-Garcia P, Esteban CR, Reddy P, Horvath S, Li J, Geng L, Hu Q, Wang S, Belmonte JCI, Ren J, Zhang W, Qu J, Liu GH. Jing Y, et al. Cell Stem Cell. 2023 Nov 2;30(11):1452-1471.e10. doi: 10.1016/j.stem.2023.09.007. Epub 2023 Oct 12. Cell Stem Cell. 2023. PMID: 37832549 Free article.
We evaluated targets whose activation antagonizes cellular senescence, among which SOX5 outperformed as a top hit. Through decoding the epigenomic landscapes remodeled by overexpressing SOX5, we uncovered its role in resetting the transcription network for geroprote …
We evaluated targets whose activation antagonizes cellular senescence, among which SOX5 outperformed as a top hit. Through decoding t …
Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency.
Zawerton A, Mignot C, Sigafoos A, Blackburn PR, Haseeb A, McWalter K, Ichikawa S, Nava C, Keren B, Charles P, Marey I, Tabet AC, Levy J, Perrin L, Hartmann A, Lesca G, Schluth-Bolard C, Monin P, Dupuis-Girod S, Guillen Sacoto MJ, Schnur RE, Zhu Z, Poisson A, El Chehadeh S, Alembik Y, Bruel AL, Lehalle D, Nambot S, Moutton S, Odent S, Jaillard S, Dubourg C, Hilhorst-Hofstee Y, Barbaro-Dieber T, Ortega L, Bhoj EJ, Masser-Frye D, Bird LM, Lindstrom K, Ramsey KM, Narayanan V, Fassi E, Willing M, Cole T, Salter CG, Akilapa R, Vandersteen A, Canham N, Rump P, Gerkes EH, Klein Wassink-Ruiter JS, Bijlsma E, Hoffer MJV, Vargas M, Wojcik A, Cherik F, Francannet C, Rosenfeld JA, Machol K, Scott DA, Bacino CA, Wang X, Clark GD, Bertoli M, Zwolinski S, Thomas RH, Akay E, Chang RC, Bressi R, Sanchez Russo R, Srour M, Russell L, Goyette AE, Dupuis L, Mendoza-Londono R, Karimov C, Joseph M, Nizon M, Cogné B, Kuechler A, Piton A; Deciphering Developmental Disorder Study; Klee EW, Lefebvre V, Clark KJ, Depienne C. Zawerton A, et al. Genet Med. 2020 Mar;22(3):524-537. doi: 10.1038/s41436-019-0657-0. Epub 2019 Oct 3. Genet Med. 2020. PMID: 31578471 Free PMC article.
RESULTS: Microdeletions and truncating variants occurred throughout SOX5. In contrast, most missense variants clustered in the pivotal SOX-specific high-mobility-group domain. The latter variants prevented SOX5 from binding DNA and promoting transactivation in vitro …
RESULTS: Microdeletions and truncating variants occurred throughout SOX5. In contrast, most missense variants clustered in the pivota …
[SOX5: A core transcription factor from development to multi-system disease regulation].
Hu GX, Yang Y, Guo JS, Li XY, Chang B, Yi XJ. Hu GX, et al. Sheng Li Xue Bao. 2025 Dec 25;77(6):1009-1022. doi: 10.13294/j.aps.2025.0080. Sheng Li Xue Bao. 2025. PMID: 41423973 Free article. Review. Chinese.
SOX5, as an important member of the SOX transcription factor family, is widely involved in various physiological and pathological processes. ...In terms of diseases, defects in SOX5 are closely associated with Lamb-Shaffer syndrome, type 2 diabetes, and respiratory …
SOX5, as an important member of the SOX transcription factor family, is widely involved in various physiological and pathological pro …
Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.
Tenorio-Castano J, Gómez ÁS, Coronado M, Rodríguez-Martín P, Parra A, Pascual P, Cazalla M, Gallego N, Arias P, Morales AV, Nevado J, Lapunzina P. Tenorio-Castano J, et al. Clin Genet. 2023 Dec;104(6):637-647. doi: 10.1111/cge.14423. Epub 2023 Sep 13. Clin Genet. 2023. PMID: 37702321 Review.
Lamb-Shaffer Syndrome (LSS; OMIM #616803; ORPHA #313892; ORPHA #313884) is an infrequent genetic disorder that affects multiple aspects of human development especially those related to the development of the nervous system. LSS is caused by variants in the SOX5 gene. At th …
Lamb-Shaffer Syndrome (LSS; OMIM #616803; ORPHA #313892; ORPHA #313884) is an infrequent genetic disorder that affects multiple aspects of h …
SOX5 inhibition overcomes PARP inhibitor resistance in BRCA-mutated breast and ovarian cancer.
Ghosh M, Kang MS, Katuwal NB, Hong SD, Park SM, Kim SG, Lee SR, Moon YW. Ghosh M, et al. Cell Death Dis. 2025 Apr 24;16(1):333. doi: 10.1038/s41419-025-07660-7. Cell Death Dis. 2025. PMID: 40274769 Free PMC article.
Therefore, strategies to overcome PARP inhibitor resistance are unmet clinical need. SRY-box transcription factor 5 (SOX5) plays a crucial role in development of various cancers but the role of SOX5 in PARP inhibitor resistance is poorly understood. ...Therefore, we …
Therefore, strategies to overcome PARP inhibitor resistance are unmet clinical need. SRY-box transcription factor 5 (SOX5) plays a cr …
Sox5 and Th17 cell differentiation.
Suto A, Tanaka S, Nakajima H. Suto A, et al. Oncotarget. 2015 Aug 21;6(24):19952-3. doi: 10.18632/oncotarget.4784. Oncotarget. 2015. PMID: 26197269 Free PMC article. No abstract available.
Identification of a novel Sox5 transcript in mouse testis.
Zheng B, Huang C, Zhou J, Ye L. Zheng B, et al. Gene Expr Patterns. 2021 Sep;41:119197. doi: 10.1016/j.gep.2021.119197. Epub 2021 Jun 22. Gene Expr Patterns. 2021. PMID: 34171463
The transcription factor SOX5 is present in two distinct isoforms in both human and mouse, L-SOX5 and S-SOX5 (long and short isoforms of SOX5). Here, we identified and characterized a novel transcript of Sox5 (S-Sox5 variant) in mouse tes …
The transcription factor SOX5 is present in two distinct isoforms in both human and mouse, L-SOX5 and S-SOX5 (long and …
SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells.
Kurtsdotter I, Topcic D, Karlén A, Singla B, Hagey DW, Bergsland M, Siesjö P, Nistér M, Carlson JW, Lefebvre V, Persson O, Holmberg J, Muhr J. Kurtsdotter I, et al. Cancer Res. 2017 Sep 15;77(18):4985-4997. doi: 10.1158/0008-5472.CAN-17-0704. Epub 2017 Jul 7. Cancer Res. 2017. PMID: 28687615 Free PMC article.
Molecular mechanisms preventing self-renewing brain stem cells from oncogenic transformation are poorly defined. We show that the expression levels of SOX5, SOX6, and SOX21 (SOX5/6/21) transcription factors increase in stem cells of the subventricular zone (SVZ) upo …
Molecular mechanisms preventing self-renewing brain stem cells from oncogenic transformation are poorly defined. We show that the expression …
Regulation and function of SOX9 during cartilage development and regeneration.
Song H, Park KH. Song H, et al. Semin Cancer Biol. 2020 Dec;67(Pt 1):12-23. doi: 10.1016/j.semcancer.2020.04.008. Epub 2020 May 4. Semin Cancer Biol. 2020. PMID: 32380234 Review.
SOX9 either works alone or in combination with downstream SOX transcription factors, SOX5 and SOX6 as chondrogenic SOX Trio. SOX9 is reduced in the articular cartilage of patients with osteoarthritis while highly maintained during tumorigenesis of cartilage and bone. ...
SOX9 either works alone or in combination with downstream SOX transcription factors, SOX5 and SOX6 as chondrogenic SOX Trio. SOX9 is …
SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer.
Wu L, Yang Z, Dai G, Fan B, Yuan J, Liu Y, Liu P, Ou Z. Wu L, et al. Acta Biochim Biophys Sin (Shanghai). 2022 Jun 25;54(7):987-998. doi: 10.3724/abbs.2022075. Acta Biochim Biophys Sin (Shanghai). 2022. PMID: 35880568 Free PMC article.
Sex determining region Y-box protein 5 (SOX5) plays important roles in a variety of human cancers. However, little research has been conducted on the function and underlying mechanism of SOX5 in BC. ...Meanwhile, ectopic SOX5 expression stimulates cell growth …
Sex determining region Y-box protein 5 (SOX5) plays important roles in a variety of human cancers. However, little research has been …
631 results