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2008 1
2009 1
2010 2
2011 1
2012 5
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2021 2
2022 0
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The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling.
Cohen J, Raviv S, Adir O, Padmanabhan K, Soffer A, Luxenburg C. Cohen J, et al. J Cell Biol. 2019 Apr 1;218(4):1390-1406. doi: 10.1083/jcb.201807216. Epub 2019 Mar 13. J Cell Biol. 2019. PMID: 30867227 Free PMC article.
Here, we identify a key role for the Wave complex proteins ABI1 and Wave2 in regulating signals that control epidermal shape and growth. In utero RNAi-mediated silencing of Abi1 or Wasf2 induced cellular hyperproliferation and defects in architecture of the interfollicular …
Here, we identify a key role for the Wave complex proteins ABI1 and Wave2 in regulating signals that control epidermal shape and grow …
Establishment and characterization of a canine keratinocyte organoid culture system.
Wiener DJ, Basak O, Asra P, Boonekamp KE, Kretzschmar K, Papaspyropoulos A, Clevers H. Wiener DJ, et al. Vet Dermatol. 2018 Oct;29(5):375-e126. doi: 10.1111/vde.12541. Epub 2018 Jul 2. Vet Dermatol. 2018. PMID: 29963730
BACKGROUND: Perturbations of epidermal and follicular homeostasis have been attributed to a variety of skin diseases affecting dogs. ...OBJECTIVES: To establish an accurate and reliable in vitro 3D system of canine keratinocyte organoids to lay the basis for studyin …
BACKGROUND: Perturbations of epidermal and follicular homeostasis have been attributed to a variety of skin diseases affecting dogs. …
Expression and functional role of Sox9 in human epidermal keratinocytes.
Shi G, Sohn KC, Li Z, Choi DK, Park YM, Kim JH, Fan YM, Nam YH, Kim S, Im M, Lee Y, Seo YJ, Kim CD, Lee JH. Shi G, et al. PLoS One. 2013;8(1):e54355. doi: 10.1371/journal.pone.0054355. Epub 2013 Jan 18. PLoS One. 2013. PMID: 23349860 Free PMC article.
In this study, we investigated the expression and putative role of Sox9 in epidermal keratinocyte. Immunohistochemical staining showed that Sox9 is predominantly expressed in the basal layer of normal human skin epidermis, and highly expressed i …
In this study, we investigated the expression and putative role of Sox9 in epidermal keratinocyte. Immunohistochemical …
Two- and three-dimensional culture of keratinocyte stem and precursor cells derived from primary murine epidermal cultures.
Vollmers A, Wallace L, Fullard N, Höher T, Alexander MD, Reichelt J. Vollmers A, et al. Stem Cell Rev Rep. 2012 Jun;8(2):402-13. doi: 10.1007/s12015-011-9314-y. Stem Cell Rev Rep. 2012. PMID: 21892602
Here we describe the successful establishment of an in vitro 3D stem cell culture model developed from clonally growing keratinocyte lines derived from neonatal mice using culture conditions previously established for human keratinocytes. ...In high calcium medium, …
Here we describe the successful establishment of an in vitro 3D stem cell culture model developed from clonally growing keratinocyte
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.
Mardaryev AN, Meier N, Poterlowicz K, Sharov AA, Sharova TY, Ahmed MI, Rapisarda V, Lewis C, Fessing MY, Ruenger TM, Bhawan J, Werner S, Paus R, Botchkarev VA. Mardaryev AN, et al. Development. 2011 Nov;138(22):4843-52. doi: 10.1242/dev.070284. Development. 2011. PMID: 22028024 Free PMC article.
Here, we show that during murine skin morphogenesis, Lhx2 is expressed in the hair follicle (HF) buds, whereas in postnatal telogen HFs Lhx2(+) cells reside in the stem cell-enriched epithelial compartments (bulge, secondary hair germ) and co-express selected stem cell markers ( …
Here, we show that during murine skin morphogenesis, Lhx2 is expressed in the hair follicle (HF) buds, whereas in postnatal telogen HFs Lhx2 …
Long-term expression pattern of melanocyte markers in light- and dark-pigmented dermo-epidermal cultured human skin substitutes.
Biedermann T, Klar AS, Böttcher-Haberzeth S, Michalczyk T, Schiestl C, Reichmann E, Meuli M. Biedermann T, et al. Pediatr Surg Int. 2015 Jan;31(1):69-76. doi: 10.1007/s00383-014-3622-7. Epub 2014 Oct 18. Pediatr Surg Int. 2015. PMID: 25326121 Free article.
PURPOSE: Transplantation of pigmented tissue-engineered human autologous skin substitutes represents a promising procedure to cover skin defects. We have already demonstrated that we can restore the patient's native light or dark skin color by adding melanocytes to our der …
PURPOSE: Transplantation of pigmented tissue-engineered human autologous skin substitutes represents a promising procedure to cover skin def …
Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells.
Yang GN, Ahangar P, Strudwick XL, Kopecki Z, Cowin AJ. Yang GN, et al. Int J Mol Sci. 2021 Jul 30;22(15):8235. doi: 10.3390/ijms22158235. Int J Mol Sci. 2021. PMID: 34361001 Free PMC article.
Epidermal progenitor cells divide symmetrically and asymmetrically to form stratified epidermis and hair follicles during late embryonic development. ...Flii(Tg)(/Tg) led to increased symmetrical cell division of EpSCs with increased cell proliferation rate, an elev
Epidermal progenitor cells divide symmetrically and asymmetrically to form stratified epidermis and hair follicles during late
Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects.
Escuin-Ordinas H, Liu Y, Sun L, Hugo W, Dimatteo R, Huang RR, Krystofinski P, Azhdam A, Lee J, Comin-Anduix B, Cochran AJ, Lo RS, Segura T, Scumpia PO, Ribas A. Escuin-Ordinas H, et al. PLoS One. 2021 Jun 23;16(6):e0252597. doi: 10.1371/journal.pone.0252597. eCollection 2021. PLoS One. 2021. PMID: 34161353 Free PMC article.
We previously found that paradoxical activation of the mitogen-activated protein kinase (MAPK) pathway via topical administration of the BRAF inhibitor vemurafenib accelerates wound healing by activating keratinocyte proliferation and reepithelialization pathways in health …
We previously found that paradoxical activation of the mitogen-activated protein kinase (MAPK) pathway via topical administration of the BRA …
Brief report: requirement of TACE/ADAM17 for hair follicle bulge niche establishment.
Nagao K, Kobayashi T, Ohyama M, Akiyama H, Horiuchi K, Amagai M. Nagao K, et al. Stem Cells. 2012 Aug;30(8):1781-5. doi: 10.1002/stem.1153. Stem Cells. 2012. PMID: 22696231 Free article.
Real-time PCR revealed downregulation of transcription factors Sox9, Lhx2, and Gata3 and upregulation of Lef1. In vitro colony-forming capacity was abolished in Tace/Sox9 keratinocytes, and HFs exhibited increased proliferation in situ, collectively demonstra …
Real-time PCR revealed downregulation of transcription factors Sox9, Lhx2, and Gata3 and upregulation of Lef1. In vitro colony-formin …
Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection.
Goldstein NB, Koster MI, Hoaglin LG, Wright MJ, Robinson SE, Robinson WA, Roop DR, Norris DA, Birlea SA. Goldstein NB, et al. Exp Dermatol. 2016 Oct;25(10):805-11. doi: 10.1111/exd.13072. Exp Dermatol. 2016. PMID: 27193292 Free PMC article.
The melanocyte-specific gene transcripts TYR, DCT, TYRP1 and PMEL were significantly upregulated in our NBUVB-treated melanocyte samples as compared with the keratinocyte samples, while keratinocyte-specific genes (KRT5 and KRT14) were expressed significantly higher …
The melanocyte-specific gene transcripts TYR, DCT, TYRP1 and PMEL were significantly upregulated in our NBUVB-treated melanocyte samples as …
20 results