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2008 1
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2012 5
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2018 2
2019 1
2020 0
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Establishment and characterization of a canine keratinocyte organoid culture system.
Wiener DJ, Basak O, Asra P, Boonekamp KE, Kretzschmar K, Papaspyropoulos A, Clevers H. Wiener DJ, et al. Vet Dermatol. 2018 Oct;29(5):375-e126. doi: 10.1111/vde.12541. Epub 2018 Jul 2. Vet Dermatol. 2018. PMID: 29963730
OBJECTIVES: To establish an accurate and reliable in vitro 3D system of canine keratinocyte organoids to lay the basis for studying functional defects in interfollicular epidermis (IFE) and hair follicle (HF) morphogenesis, reconstitution and differentiation that le …
OBJECTIVES: To establish an accurate and reliable in vitro 3D system of canine keratinocyte organoids to lay the basis for studying f …
Expression and functional role of Sox9 in human epidermal keratinocytes.
Shi G, Sohn KC, Li Z, Choi DK, Park YM, Kim JH, Fan YM, Nam YH, Kim S, Im M, Lee Y, Seo YJ, Kim CD, Lee JH. Shi G, et al. PLoS One. 2013;8(1):e54355. doi: 10.1371/journal.pone.0054355. Epub 2013 Jan 18. PLoS One. 2013. PMID: 23349860 Free PMC article.
In this study, we investigated the expression and putative role of Sox9 in epidermal keratinocyte. Immunohistochemical staining showed that Sox9 is predominantly expressed in the basal layer of normal human skin epidermis, and highly expressed i …
In this study, we investigated the expression and putative role of Sox9 in epidermal keratinocyte. Immunohistochemical …
The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling.
Cohen J, Raviv S, Adir O, Padmanabhan K, Soffer A, Luxenburg C. Cohen J, et al. J Cell Biol. 2019 Apr 1;218(4):1390-1406. doi: 10.1083/jcb.201807216. Epub 2019 Mar 13. J Cell Biol. 2019. PMID: 30867227 Free PMC article.
Here, we identify a key role for the Wave complex proteins ABI1 and Wave2 in regulating signals that control epidermal shape and growth. ...Our results identify a novel role for Wave complex- and actin-regulated signaling via Wnt and SOX9 in skin development....
Here, we identify a key role for the Wave complex proteins ABI1 and Wave2 in regulating signals that control epidermal shape and grow …
Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development.
Tripurani SK, Wang Y, Fan YX, Rahimi M, Wong L, Lee MH, Starost MF, Rubin JS, Johnson GR. Tripurani SK, et al. Mol Biol Cell. 2018 Nov 1;29(22):2784-2799. doi: 10.1091/mbc.E18-08-0488. Epub 2018 Sep 6. Mol Biol Cell. 2018. PMID: 30188763 Free PMC article.
Mice that lack the epidermal growth factor receptor (EGFR) fail to develop a hair coat, but the mechanism responsible for this deficit is not completely understood. ...Using primary keratinocytes, we linked ligand-induced EGFR activation to suppression of nascent mR …
Mice that lack the epidermal growth factor receptor (EGFR) fail to develop a hair coat, but the mechanism responsible for this defici …
Two- and three-dimensional culture of keratinocyte stem and precursor cells derived from primary murine epidermal cultures.
Vollmers A, Wallace L, Fullard N, Höher T, Alexander MD, Reichelt J. Vollmers A, et al. Stem Cell Rev Rep. 2012 Jun;8(2):402-13. doi: 10.1007/s12015-011-9314-y. Stem Cell Rev Rep. 2012. PMID: 21892602
Here we describe the successful establishment of an in vitro 3D stem cell culture model developed from clonally growing keratinocyte lines derived from neonatal mice using culture conditions previously established for human keratinocytes. ...In high calcium medium, …
Here we describe the successful establishment of an in vitro 3D stem cell culture model developed from clonally growing keratinocyte
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.
Mardaryev AN, Meier N, Poterlowicz K, Sharov AA, Sharova TY, Ahmed MI, Rapisarda V, Lewis C, Fessing MY, Ruenger TM, Bhawan J, Werner S, Paus R, Botchkarev VA. Mardaryev AN, et al. Development. 2011 Nov;138(22):4843-52. doi: 10.1242/dev.070284. Development. 2011. PMID: 22028024 Free PMC article.
Finally, Chip-on-chip/ChIP-qPCR and reporter assay analyses identified Sox9, Tcf4 and Lgr5 as direct Lhx2 targets in keratinocytes. These data strongly suggest that Lhx2 positively regulates Sox9 and Tcf4 in the bulge cells, and promotes wound re-epithelizati …
Finally, Chip-on-chip/ChIP-qPCR and reporter assay analyses identified Sox9, Tcf4 and Lgr5 as direct Lhx2 targets in keratinocytes
Long-term expression pattern of melanocyte markers in light- and dark-pigmented dermo-epidermal cultured human skin substitutes.
Biedermann T, Klar AS, Böttcher-Haberzeth S, Michalczyk T, Schiestl C, Reichmann E, Meuli M. Biedermann T, et al. Pediatr Surg Int. 2015 Jan;31(1):69-76. doi: 10.1007/s00383-014-3622-7. Epub 2014 Oct 18. Pediatr Surg Int. 2015. PMID: 25326121
We have already demonstrated that we can restore the patient's native light or dark skin color by adding melanocytes to our dermo-epidermal skin analogs. ...METHODS: Human epidermal melanocytes and keratinocytes, as well as dermal fibroblasts from ligh …
We have already demonstrated that we can restore the patient's native light or dark skin color by adding melanocytes to our dermo- …
Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection.
Goldstein NB, Koster MI, Hoaglin LG, Wright MJ, Robinson SE, Robinson WA, Roop DR, Norris DA, Birlea SA. Goldstein NB, et al. Exp Dermatol. 2016 Oct;25(10):805-11. doi: 10.1111/exd.13072. Exp Dermatol. 2016. PMID: 27193292 Free PMC article.
Furthermore, in both NBUVB-treated vitiligo skin and normal skin, when bulge melanocytes were compared with epidermal melanocytes, we found significantly lower expression of melanocyte-specific genes and significantly higher expression of three melanocytic stem cell genes …
Furthermore, in both NBUVB-treated vitiligo skin and normal skin, when bulge melanocytes were compared with epidermal melanocytes, we …
Brief report: requirement of TACE/ADAM17 for hair follicle bulge niche establishment.
Nagao K, Kobayashi T, Ohyama M, Akiyama H, Horiuchi K, Amagai M. Nagao K, et al. Stem Cells. 2012 Aug;30(8):1781-5. doi: 10.1002/stem.1153. Stem Cells. 2012. PMID: 22696231 Free article.
In vitro colony-forming capacity was abolished in Tace/Sox9 keratinocytes, and HFs exhibited increased proliferation in situ, collectively demonstrating that Tace/Sox9 mice failed to establish the bulge niche and to maintain "stemness" of HF stem cells. Ep
In vitro colony-forming capacity was abolished in Tace/Sox9 keratinocytes, and HFs exhibited increased proliferation in situ, …
Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis.
da Silva-Diz V, Solé-Sánchez S, Valdés-Gutiérrez A, Urpí M, Riba-Artés D, Penin RM, Pascual G, González-Suárez E, Casanovas O, Viñals F, Paramio JM, Batlle E, Muñoz P. da Silva-Diz V, et al. Oncogene. 2013 Aug 8;32(32):3732-43. doi: 10.1038/onc.2012.375. Epub 2012 Sep 3. Oncogene. 2013. PMID: 22945646
Epidermal keratinocytes and hair follicle (HF) stem cells (SCs) expressing oncogenes are competent at developing squamous cell carcinomas (SCCs) in epidermis and HFs, respectively. To determine whether bulge and hair germ (HG) SCs from HF contribute to SCC ge
Epidermal keratinocytes and hair follicle (HF) stem cells (SCs) expressing oncogenes are competent at developing squamous cell
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