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278 results

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Page 1
LINC01094/SPI1/CCL7 Axis Promotes Macrophage Accumulation in Lung Adenocarcinoma and Tumor Cell Dissemination.
Wu Z, Bai X, Lu Z, Liu S, Jiang H. Wu Z, et al. J Immunol Res. 2022 Sep 9;2022:6450721. doi: 10.1155/2022/6450721. eCollection 2022. J Immunol Res. 2022. PMID: 36118415 Free PMC article.
Knockdown of CCL7 suppressed the chemotaxis and M2 skewing of macrophages, and it blocked the EMT and mobility of LUAD cells. CCL7 downregulation also suppressed macrophage infiltration in xenograft tumors in mice. ...Upregulation of SPI1 restored the chemota …
Knockdown of CCL7 suppressed the chemotaxis and M2 skewing of macrophages, and it blocked the EMT and mobility of LUAD cells. CCL7 do …
Spi1 regulates the microglial/macrophage inflammatory response via the PI3K/AKT/mTOR signaling pathway after intracerebral hemorrhage.
Zhang G, Lu J, Zheng J, Mei S, Li H, Zhang X, Ping A, Gao S, Fang Y, Yu J. Zhang G, et al. Neural Regen Res. 2024 Jan;19(1):161-170. doi: 10.4103/1673-5374.375343. Neural Regen Res. 2024. PMID: 37488863 Free PMC article.
The E26 transformation-specific sequence-related transcription factor Spi1 regulates microglial/macrophage commitment and maturation. However, the effect of Spi1 on intracerebral hemorrhage remains unclear. ...In conclusion, our results suggest that Spi1 …
The E26 transformation-specific sequence-related transcription factor Spi1 regulates microglial/macrophage commitment and matu …
Integrin beta8 Facilitates Macrophage Infiltration and Polarization by Regulating CCL5 to Promote LUAD Progression.
Song L, Yu X, Wu Y, Zhang W, Zhang Y, Shao Y, Hou Z, Yang C, Gao Y, Zhao Y. Song L, et al. Adv Sci (Weinh). 2025 Jan;12(2):e2406865. doi: 10.1002/advs.202406865. Epub 2024 Nov 13. Adv Sci (Weinh). 2025. PMID: 39535362 Free PMC article.
Moreover, interleukin 8 (IL8) and interleukin 10 (IL10) produced by M2-like macrophages regulate the expression of ITGbeta8 in LUAD cells through the spi-1 proto-oncogene (SPI1). This study elucidates the feedback mechanism of ITGbeta8 between LUAD cells and macr …
Moreover, interleukin 8 (IL8) and interleukin 10 (IL10) produced by M2-like macrophages regulate the expression of ITGbeta8 in LUAD c …
SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.
Jin J, Du X, Zhou L, Yao D, Zou Q. Jin J, et al. J Obstet Gynaecol Res. 2022 Sep;48(9):2419-2430. doi: 10.1111/jog.15336. Epub 2022 Jun 30. J Obstet Gynaecol Res. 2022. PMID: 35770729
The mRNA and protein levels of genes were examined by RT-qPCR and western blot assays, respectively. The effect of SPIB on macrophage cells was tested by macrophage recruitment assay and bioinformatics analysis. ...Higher SPIB expression was associated with less M2 …
The mRNA and protein levels of genes were examined by RT-qPCR and western blot assays, respectively. The effect of SPIB on macrophage …
An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis.
Cui HK, Tang CJ, Gao Y, Li ZA, Zhang J, Li YD. Cui HK, et al. Front Immunol. 2023 Dec 21;14:1289223. doi: 10.3389/fimmu.2023.1289223. eCollection 2023. Front Immunol. 2023. PMID: 38179058 Free PMC article.
Further, we scored the HALLMARK_COMPLEMENT signaling pathway using ssGSEA and confirmed hub gene expression through qRT-PCR in RAW264.7 macrophages and apoE-/- mice. Furthermore, the risk association between C1Q and HAP was assessed through bidirectional MR analysis, with …
Further, we scored the HALLMARK_COMPLEMENT signaling pathway using ssGSEA and confirmed hub gene expression through qRT-PCR in RAW264.7 m …
SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cells and immunosuppressive polarization of macrophages.
Fan Y, Gao Z, Xu J, Wang H, Guo Q, Li B, Li M, Xu H, Qi Y, Zhao S, Qiu W, Pan Z, Wang Q, Xue H, Zhao R, Guo X, Li G. Fan Y, et al. Theranostics. 2023 May 27;13(10):3310-3329. doi: 10.7150/thno.82590. eCollection 2023. Theranostics. 2023. PMID: 37351164 Free PMC article.
Moreover, cotranscribed miR221 and miR222 can be delivered to macrophages via exosomes to target SOCS3, causing immunosuppressive polarization. Finally, PLX-4720 sensitivity is associated with SPI1 expression and acts on MES GSCs to enhance radiosensitivity. Conclus …
Moreover, cotranscribed miR221 and miR222 can be delivered to macrophages via exosomes to target SOCS3, causing immunosuppressive pol …
YTHDF2 favors protumoral macrophage polarization and implies poor survival outcomes in triple negative breast cancer.
Jin H, Chen Y, Zhang D, Lin J, Huang S, Wu X, Deng W, Huang J, Yao Y. Jin H, et al. iScience. 2024 May 3;27(6):109902. doi: 10.1016/j.isci.2024.109902. eCollection 2024 Jun 21. iScience. 2024. PMID: 38812540 Free PMC article.
In this study, we focused on YTHDF2, an N6-methyladenosine (m(6)A) RNA-reader protein, in macrophages, one of the most abundant intra-tumoral immune cells. Using single-cell sequencing and ex vivo experiments, we discovered that YTHDF2 significantly promotes pro-tumoral ph …
In this study, we focused on YTHDF2, an N6-methyladenosine (m(6)A) RNA-reader protein, in macrophages, one of the most abundant intra …
Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence.
Jiang L, Wang P, Song X, Zhang H, Ma S, Wang J, Li W, Lv R, Liu X, Ma S, Yan J, Zhou H, Huang D, Cheng Z, Yang C, Feng L, Wang L. Jiang L, et al. Nat Commun. 2021 Feb 9;12(1):879. doi: 10.1038/s41467-021-21186-4. Nat Commun. 2021. PMID: 33563986 Free PMC article.
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. . …
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infect …
SPI1-mediated transcriptional activation of CEP55 promotes the malignant growth of triple-negative breast cancer and M2 macrophage polarization.
Liu Y, Dong M, Jia Y, Yang D, Hui Y, Yang X. Liu Y, et al. Pathol Res Pract. 2024 Oct;262:155544. doi: 10.1016/j.prp.2024.155544. Epub 2024 Aug 13. Pathol Res Pract. 2024. PMID: 39197215
Further, CEP55 overexpression relieved SPI1 silencing-induced inhibitory effects on TNBC cell migration, invasion, proliferation, glucose metabolism, and M2 macrophage polarization. CONCLUSION: SPI1-mediated transcriptional activation of CEP55 plays a key rol …
Further, CEP55 overexpression relieved SPI1 silencing-induced inhibitory effects on TNBC cell migration, invasion, proliferation, glu …
SPI1(+)CD68(+) macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategies.
Deng G, Wang P, Su R, Sun X, Wu Z, Huang Z, Gu L, Yu H, Zhao Z, He Y, Huo M, Zhang C, Yin S. Deng G, et al. J Immunother Cancer. 2024 Oct 24;12(10):e009983. doi: 10.1136/jitc-2024-009983. J Immunother Cancer. 2024. PMID: 39455096 Free PMC article.
RESULTS: Single-cell transcriptome analysis and immunohistochemistry demonstrated that SPI1 was expressed in macrophages, with a higher enrichment in metastatic lesions than in primary tumors. Higher SPI1(+)CD68(+) TAMs infiltration was associated with poor o …
RESULTS: Single-cell transcriptome analysis and immunohistochemistry demonstrated that SPI1 was expressed in macrophages, with …
278 results