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Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks.

Tansey KE, Cameron D, Hill MJ. Tansey KE, et al. Genome Med. 2018 Feb 26;10(1):14. doi: 10.1186/s13073-018-0523-8. Genome Med. 2018. PMID: 29482603 Free PMC article.

BACKGROUND: Genome-wide association studies of Alzheimer's disease (AD) have identified a number of significant risk loci, the majority of which lie in non-coding regions of the genome. ...Partitioned heritability using LDscore regression was used to investigate the contri …

BACKGROUND: Genome-wide association studies of Alzheimer's disease (AD) have identified a number of significant risk loci, the majori …

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Biochanin a Enhances the Defense Against Salmonella enterica Infection Through AMPK/ULK1/mTOR-Mediated Autophagy and Extracellular Traps and Reversing SPI-1-Dependent Macrophage (MΦ) M2 Polarization.

Zhao X, Tang X, Guo N, An Y, Chen X, Shi C, Wang C, Li Y, Li S, Xu H, Liu M, Wang Y, Yu L. Zhao X, et al. Front Cell Infect Microbiol. 2018 Sep 11;8:318. doi: 10.3389/fcimb.2018.00318. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 30271755 Free PMC article.

A novel treatment regimen for bacterial infections is the pharmacological enhancement of the host's immune defenses. We demonstrated that biochanin A (BCA), an isoflavone constituent in some plants, could enhance both intra- and extracellular bactericidal activity of host …

A novel treatment regimen for bacterial infections is the pharmacological enhancement of the host's immune defenses. We demonstrated …

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The Transcription Factors PU.1 and IRF4 Determine Dendritic Cell-Specific Expression of RALDH2.

Yashiro T, Yamaguchi M, Watanuki Y, Kasakura K, Nishiyama C. Yashiro T, et al. J Immunol. 2018 Dec 15;201(12):3677-3682. doi: 10.4049/jimmunol.1800492. Epub 2018 Nov 9. J Immunol. 2018. PMID: 30413670 Free article.

The effect of small interfering RNAs for Spi1 and Irf4 and specific binding of PU.1 and IRF4 on the Aldh1a2 gene were also observed in DCs freshly isolated from spleen and mesenteric lymph nodes, respectively. ...

The effect of small interfering RNAs for Spi1 and Irf4 and specific binding of PU.1 and IRF4 on the Aldh1a2 gene were also observed i …

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phoP, SPI1, SPI2 and aroA mutants of Salmonella Enteritidis induce a different immune response in chickens.

Elsheimer-Matulova M, Varmuzova K, Kyrova K, Havlickova H, Sisak F, Rahman M, Rychlik I. Elsheimer-Matulova M, et al. Vet Res. 2015 Sep 17;46(1):96. doi: 10.1186/s13567-015-0224-x. Vet Res. 2015. PMID: 26380970 Free PMC article.

In this study we therefore characterized the interactions between chickens and phoP, aroA, SPI1 and SPI2 mutants of S. Enteritidis. First we tested the response of HD11 chicken macrophage-like cell line to S. Enteritidis infection monitoring the transc …

In this study we therefore characterized the interactions between chickens and phoP, aroA, SPI1 and SPI2 mutants of S. Enterit …

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The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses.

Bierschenk D, Monteleone M, Moghaddas F, Baker PJ, Masters SL, Boucher D, Schroder K. Bierschenk D, et al. J Leukoc Biol. 2019 Feb;105(2):401-410. doi: 10.1002/JLB.MA0318-112RR. Epub 2018 Oct 4. J Leukoc Biol. 2019. PMID: 30368901

Typhimurium-induced inflammasome responses from primary human macrophages, resulting in strong IL-1β production and macrophage death. ...Our data suggest that Salmonella employs the SPI2 T3SS to subvert SPI1-induced NLRP3 and NLRC4 inflammasome responses in h …

Typhimurium-induced inflammasome responses from primary human macrophages, resulting in strong IL-1β production and macrophage …

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A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

Huang KL, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BP, Czajkowski J, Chouraki V, Grenier-Boley B, Bellenguez C, Deming Y, McKenzie A, Raj T, Renton AE, Budde J, Smith A, Fitzpatrick A, Bis JC, DeStefano A, Adams HHH, Ikram MA, van der Lee S, Del-Aguila JL, Fernandez MV, Ibañez L; International Genomics of Alzheimer's Project; Alzheimer's Disease Neuroimaging Initiative, Sims R, Escott-Price V, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Lambert JC, van Duijn C, Launer L, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Zhang B, Borecki I, Kauwe JSK, Cruchaga C, Hao K, Goate AM. Huang KL, et al. Nat Neurosci. 2017 Aug;20(8):1052-1061. doi: 10.1038/nn.4587. Epub 2017 Jun 19. Nat Neurosci. 2017. PMID: 28628103 Free PMC article.

A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849 controls identified eight previously reported AD risk loci and 14 novel loci associated with age at onset. ...The minor allele of rs1057233 (G), within the previously reported CELF1 AD risk …

A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849 controls identified eight previously reported AD …

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Breakdown of multiple sclerosis genetics to identify an integrated disease network and potential variant mechanisms.

Shepard CJ, Cline SG, Hinds D, Jahanbakhsh S, Prokop JW. Shepard CJ, et al. Physiol Genomics. 2019 Nov 1;51(11):562-577. doi: 10.1152/physiolgenomics.00120.2018. Epub 2019 Sep 4. Physiol Genomics. 2019. PMID: 31482761

Tissue-specific expression and eQTLs of MS genes implicate multiple immune cell types including macrophages, neutrophils, and T cells, while the genes in neural cell types enrich for oligodendrocyte and myelin sheath biology. ...Using multiple functional genomic databases, …

Tissue-specific expression and eQTLs of MS genes implicate multiple immune cell types including macrophages, neutrophils, and T cells …

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PhoP-Mediated Repression of the SPI1 Type 3 Secretion System in Salmonella enterica Serovar Typhimurium.

Palmer AD, Kim K, Slauch JM. Palmer AD, et al. J Bacteriol. 2019 Jul 24;201(16):e00264-19. doi: 10.1128/JB.00264-19. Print 2019 Aug 15. J Bacteriol. 2019. PMID: 31182495 Free PMC article.

Salmonella infects intestinal epithelial cells using a type 3 secretion system (T3SS) encoded on Salmonella pathogenicity island 1 (SPI1). ...Once inside the phagosomes of epithelial cells, or in macrophages during systemic stages of disease, the SPI1 T3SS is …

Salmonella infects intestinal epithelial cells using a type 3 secretion system (T3SS) encoded on Salmonella pathogenicity island 1 (SPI1 …

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Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages.

Buchrieser J, James W, Moore MD. Buchrieser J, et al. Stem Cell Reports. 2017 Feb 14;8(2):334-345. doi: 10.1016/j.stemcr.2016.12.020. Epub 2017 Jan 19. Stem Cell Reports. 2017. PMID: 28111278 Free PMC article.

By using a CRISPR-Cas9 knockout strategy, we show that human iPSC-derived monocytes/macrophages develop in an MYB-independent, RUNX1-, and SPI1 (PU.1)-dependent fashion. This result makes human iPSC-derived macrophages developmentally related to and a good mo …

By using a CRISPR-Cas9 knockout strategy, we show that human iPSC-derived monocytes/macrophages develop in an MYB-independent, RUNX1- …

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A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia.

Satoh J, Asahina N, Kitano S, Kino Y. Satoh J, et al. Gene Regul Syst Bio. 2014 Dec 8;8:127-39. doi: 10.4137/GRSB.S19711. eCollection 2014. Gene Regul Syst Bio. 2014. PMID: 25574134 Free PMC article.

Microglia, rapidly activated in response to proinflammatory stimuli, are accumulated in brain lesions of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. ...By using pathway analysis tools of bioinformatics, we found that ChIP-Seq-bas …

Microglia, rapidly activated in response to proinflammatory stimuli, are accumulated in brain lesions of neurodegenerative diseases, such as …

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