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324 results

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Page 1
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Li Q, Zhang L, You W, Xu J, Dai J, Hua D, Zhang R, Yao F, Zhou S, Huang W, Dai Y, Zhang Y, Baheti T, Qian X, Pu L, Xu J, Xia Y, Zhang C, Tang J, Wang X. Li Q, et al. Nat Commun. 2022 Dec 12;13(1):7677. doi: 10.1038/s41467-022-35469-x. Nat Commun. 2022. PMID: 36509766 Free PMC article.
Mechanistically, PRDM1 enhances USP22 transcription, thus reducing SPI1 protein degradation through deubiquitination, which enhances PD-L1 transcription. ...Collectively, we demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated …
Mechanistically, PRDM1 enhances USP22 transcription, thus reducing SPI1 protein degradation through deubiquitination, which enhances …
SPI1(+)CD68(+) macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategies.
Deng G, Wang P, Su R, Sun X, Wu Z, Huang Z, Gu L, Yu H, Zhao Z, He Y, Huo M, Zhang C, Yin S. Deng G, et al. J Immunother Cancer. 2024 Oct 24;12(10):e009983. doi: 10.1136/jitc-2024-009983. J Immunother Cancer. 2024. PMID: 39455096 Free PMC article.
However, the different subpopulations of TAMs and their roles in gastric cancer (GC) remain poorly understood. This study aims to assess the effects of Spi-1 proto-oncogene (SPI1)(+)CD68(+) TAMs in GC. ...Higher SPI1(+)CD68(+) TAMs infiltration was associated …
However, the different subpopulations of TAMs and their roles in gastric cancer (GC) remain poorly understood. This study aims to ass …
IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis.
Chen Y, Lin B, Yang S, Huang J. Chen Y, et al. Exp Cell Res. 2023 Oct 1;431(1):113733. doi: 10.1016/j.yexcr.2023.113733. Epub 2023 Jul 29. Exp Cell Res. 2023. PMID: 37517591
IRF1 could bind to SPI1 and suppress its transcriptional activating effects on GPX4 expression. SPI1 overexpression reduced ROS and lipid ROS accumulation and increased colon cancer cell viability and colony formation upon erastin induction. ...In conclusion, …
IRF1 could bind to SPI1 and suppress its transcriptional activating effects on GPX4 expression. SPI1 overexpression reduced RO …
SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway.
Qiu P, Li X, Gong M, Wen P, Wen J, Xu L, Wang G. Qiu P, et al. Can J Gastroenterol Hepatol. 2023 Mar 17;2023:2021515. doi: 10.1155/2023/2021515. eCollection 2023. Can J Gastroenterol Hepatol. 2023. PMID: 36967718 Free PMC article.
Gastric cancer (GC) is a common digestive tract malignancy worldwide. N-myristoyltransferase 1 (NMT1) has been implicated in many cancers, but its association with gastric cancer remains to be clarified. ...SPI1 upregulated NMT1 to facilitate the malig …
Gastric cancer (GC) is a common digestive tract malignancy worldwide. N-myristoyltransferase 1 (NMT1) has been implicated in many …
SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.
Jin J, Du X, Zhou L, Yao D, Zou Q. Jin J, et al. J Obstet Gynaecol Res. 2022 Sep;48(9):2419-2430. doi: 10.1111/jog.15336. Epub 2022 Jun 30. J Obstet Gynaecol Res. 2022. PMID: 35770729
AIM: The functions and molecular mechanisms of SPI1-related protein (SPIB) were examined in cervical cancer (CC) cells. METHODS: Genes related to miscarriage and prognosis in CC were identified by Kaplan-Meier and differential expression analysis, respectively. ...
AIM: The functions and molecular mechanisms of SPI1-related protein (SPIB) were examined in cervical cancer (CC) cells. METHOD …
Therapeutic targeting of SPIB/SPI1-facilitated interplay of cancer cells and neutrophils inhibits aerobic glycolysis and cancer progression.
Wang J, Wang X, Guo Y, Ye L, Li D, Hu A, Cai S, Yuan B, Jin S, Zhou Y, Li Q, Zheng L, Tong Q. Wang J, et al. Clin Transl Med. 2021 Nov;11(11):e588. doi: 10.1002/ctm2.588. Clin Transl Med. 2021. PMID: 34841706 Free PMC article.
Mechanistically, neutrophils delivered SPI1 mRNA via extracellular vesicles, resulting in enhanced SPI1 expression of cancer cells. ...CONCLUSIONS: Therapeutic targeting of SPIB/SPI1-facilitated interplay of cancerous cells and neutrophils suppr …
Mechanistically, neutrophils delivered SPI1 mRNA via extracellular vesicles, resulting in enhanced SPI1 expression of cance …
EIF4A3 induced circABCA5 promotes the gastric cancer progression by SPI1 mediated IL6/JAK2/STAT3 signaling.
Hou G, Zuo H, Shi J, Dai D, Wang H, Song X, Xu G, Tao G. Hou G, et al. Am J Cancer Res. 2023 Feb 15;13(2):602-622. eCollection 2023. Am J Cancer Res. 2023. PMID: 36895988 Free PMC article.
Mechanistically, both RIP and RNA pulldown assays confirmed that circABCA5 could bind to the SPI1 protein, upregulate SPI1 expression, and promote its nuclear translocation. SPI1 could further promote the malignant phenotype of gastric cancer by activa …
Mechanistically, both RIP and RNA pulldown assays confirmed that circABCA5 could bind to the SPI1 protein, upregulate SPI1 exp …
MIR503HG impeded ovarian cancer progression by interacting with SPI1 and preventing TMEFF1 transcription.
Tian J, Yang L, Wang Z, Yan H. Tian J, et al. Aging (Albany NY). 2022 Jun 28;14(13):5390-5405. doi: 10.18632/aging.204147. Epub 2022 Jun 28. Aging (Albany NY). 2022. PMID: 35771155 Free PMC article.
MIR503 host gene (MIR503HG) acts as an important tumor suppressor in many human cancers, but its role and regulatory mechanism in ovarian cancer need to be further studied. ...In conclusion, MIR503HG acted as a tumor suppressor lncRNA in ovarian cancer by sup …
MIR503 host gene (MIR503HG) acts as an important tumor suppressor in many human cancers, but its role and regulatory mechanism in ova …
SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cells and immunosuppressive polarization of macrophages.
Fan Y, Gao Z, Xu J, Wang H, Guo Q, Li B, Li M, Xu H, Qi Y, Zhao S, Qiu W, Pan Z, Wang Q, Xue H, Zhao R, Guo X, Li G. Fan Y, et al. Theranostics. 2023 May 27;13(10):3310-3329. doi: 10.7150/thno.82590. eCollection 2023. Theranostics. 2023. PMID: 37351164 Free PMC article.
Results: MIR222HG, the expression of which can be induced by SPI1, has high levels in MES GBM tissues. Functionally, we demonstrated that MIR222HG promotes the MES transition and radioresistance in GSCs in vivo and in vitro. ...Finally, PLX-4720 sensitivity is associated w …
Results: MIR222HG, the expression of which can be induced by SPI1, has high levels in MES GBM tissues. Functionally, we demonstrated …
Comprehensive Analysis of Immune Implications and Prognostic Value of SPI1 in Gastric Cancer.
Huang J, Chen W, Jie Z, Jiang M. Huang J, et al. Front Oncol. 2022 Feb 14;12:820568. doi: 10.3389/fonc.2022.820568. eCollection 2022. Front Oncol. 2022. PMID: 35237521 Free PMC article.
However, the potential role of SPI1 in gastric cancer (GC) and the correlations between SPI1 and immune infiltration remain unclear. METHODS: In the present study, multiple databases including ONCOMINE, TIMER, Kaplan-Meier Plotter, and The Cancer Genom …
However, the potential role of SPI1 in gastric cancer (GC) and the correlations between SPI1 and immune infiltration re …
324 results