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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
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1987 4
1988 3
1989 3
1990 3
1991 10
1992 5
1993 4
1994 4
1995 4
1996 12
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1998 6
1999 13
2000 16
2001 16
2002 29
2003 40
2004 46
2005 44
2006 48
2007 51
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2009 63
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2011 72
2012 100
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2026 1

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3,136 results

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Page 1
Immunomodulation of periodontitis with SPMs.
Sahni V, Van Dyke TE. Sahni V, et al. Front Oral Health. 2023 Oct 20;4:1288722. doi: 10.3389/froh.2023.1288722. eCollection 2023. Front Oral Health. 2023. PMID: 37927821 Free PMC article. Review.
The discovery of specialized pro-resolving mediators (SPMs) resulted in a paradigm shift in our understanding of disease etiopathology. Periodontal disease, traditionally considered as one of microbial etiology, is now understood to be an inflammation-driven process associ …
The discovery of specialized pro-resolving mediators (SPMs) resulted in a paradigm shift in our understanding of disease etiopatholog …
SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.
Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S. Alnouri MW, et al. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2407130121. doi: 10.1073/pnas.2407130121. Epub 2024 Oct 4. Proc Natl Acad Sci U S A. 2024. PMID: 39365815 Free PMC article.
How SPMs exert their anti-inflammatory and pro-resolving effects is, however, not clear. Here, we show that SPMs such as protectins, maresins, and D-series resolvins function as biased positive allosteric modulators (PAM) of the prostaglandin E(2) (PGE(2)) receptor …
How SPMs exert their anti-inflammatory and pro-resolving effects is, however, not clear. Here, we show that SPMs such as prote …
Secondary Progressive Multiple Sclerosis: New Insights.
Cree BAC, Arnold DL, Chataway J, Chitnis T, Fox RJ, Pozo Ramajo A, Murphy N, Lassmann H. Cree BAC, et al. Neurology. 2021 Aug 24;97(8):378-388. doi: 10.1212/WNL.0000000000012323. Epub 2021 Jun 4. Neurology. 2021. PMID: 34088878 Free PMC article. Review.
Major differences exist between relapsing-remitting MS (RRMS) and SPMS, especially regarding therapeutic response to treatment. This review provides an overview of the pathology, differentiation, and challenges in the diagnosis and treatment of SPMS. ...Early identi …
Major differences exist between relapsing-remitting MS (RRMS) and SPMS, especially regarding therapeutic response to treatment. This …
A focus on secondary progressive multiple sclerosis (SPMS): challenges in diagnosis and definition.
Inojosa H, Proschmann U, Akgün K, Ziemssen T. Inojosa H, et al. J Neurol. 2021 Apr;268(4):1210-1221. doi: 10.1007/s00415-019-09489-5. Epub 2019 Jul 30. J Neurol. 2021. PMID: 31363847 Review.
Secondary progressive multiple sclerosis (SPMS) is the second most common form of multiple sclerosis (MS). One in two relapse remitting multiple sclerosis (RRMS) patients will develop SPMS within 15 years and up to two-thirds after 30 years, leading to a progressive …
Secondary progressive multiple sclerosis (SPMS) is the second most common form of multiple sclerosis (MS). One in two relapse remitti …
The uncertainty period preceding the clinical defined SPMS diagnosis and the applicability of objective classifiers - A Danish single center study.
Holm RP, Pontieri L, Wandall-Holm MF, Framke E, Sellebjerg F, Magyari M. Holm RP, et al. Mult Scler Relat Disord. 2023 Mar;71:104546. doi: 10.1016/j.msard.2023.104546. Epub 2023 Feb 3. Mult Scler Relat Disord. 2023. PMID: 36764284 Free article. Review.
BACKGROUND: The clinical transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) is often related to a period of diagnostic uncertainty delaying diagnosis. With emerging treatment options for SPMS how to identify RRMS patient …
BACKGROUND: The clinical transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) is often re …
Specialized pro-resolving mediator network: an update on production and actions.
Chiang N, Serhan CN. Chiang N, et al. Essays Biochem. 2020 Sep 23;64(3):443-462. doi: 10.1042/EBC20200018. Essays Biochem. 2020. PMID: 32885825 Free PMC article. Review.
The resolution phase is now widely recognized as a biosynthetically active process, governed by a superfamily of endogenous chemical mediators that stimulate resolution of inflammatory responses, namely specialized proresolving mediators (SPMs). Because resolution is the n …
The resolution phase is now widely recognized as a biosynthetically active process, governed by a superfamily of endogenous chemical mediato …
E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition.
Serhan CN, Libreros S, Nshimiyimana R. Serhan CN, et al. Semin Immunol. 2022 Jan;59:101597. doi: 10.1016/j.smim.2022.101597. Epub 2022 Feb 16. Semin Immunol. 2022. PMID: 35227568 Free PMC article. Review.
These resolution phase functions of the acute inflammatory response are enhanced by SPMs, which together prepare the inflammatory loci for homeostasis and stimulate tissue regeneration via activating stem cells and the biosynthesis of novel cys-SPMs (e.g. MCTRs, PCT …
These resolution phase functions of the acute inflammatory response are enhanced by SPMs, which together prepare the inflammatory loc …
Advances in the Chemistry and Biology of Specialised Pro-Resolving Mediators (SPMs).
Byrne L, Guiry PJ. Byrne L, et al. Molecules. 2024 May 10;29(10):2233. doi: 10.3390/molecules29102233. Molecules. 2024. PMID: 38792095 Free PMC article. Review.
This review article assembles key recent advances in the synthetic chemistry and biology of specialised pro-resolving mediators (SPMs). The major medicinal chemistry developments in the design, synthesis and biological evaluation of synthetic SPM analogues of lipoxins and …
This review article assembles key recent advances in the synthetic chemistry and biology of specialised pro-resolving mediators (SPMs …
The role of specialized pro-resolving mediators (SPMs) in inflammatory arthritis: A therapeutic strategy.
Natami M, Hosseini SM, Khaleel RA, Addulrahman TS, Zarei M, Asadi S, Gholami S, Mehrvar A. Natami M, et al. Prostaglandins Other Lipid Mediat. 2024 Feb;170:106798. doi: 10.1016/j.prostaglandins.2023.106798. Epub 2023 Nov 17. Prostaglandins Other Lipid Mediat. 2024. PMID: 37977352 Review.
SPMs are synthesized by immune cells through the enzymatic conversion of omega-3 fatty acids. In the context of RA, there is a possibility of dysregulation in the production of these SPMs. In this review, we delve into the present comprehension of the endogenous fun …
SPMs are synthesized by immune cells through the enzymatic conversion of omega-3 fatty acids. In the context of RA, there is a possib …
Age-stratified associations between radiotherapy and SPMs for FPHNC: a population-based cohort study.
Li YY, Liu Q, Ying SQ, Wu XQ, Zhang XH, Xie XM, Sui BD, Jin Y, Jiao Y, Tay FR. Li YY, et al. Mil Med Res. 2025 May 21;12(1):22. doi: 10.1186/s40779-025-00612-4. Mil Med Res. 2025. PMID: 40399955 Free PMC article.
BACKGROUND: Second primary malignancies (SPMs) account for over 30% of total deaths in head and neck cancer (HNC) patients. The increasing use of radiotherapy raises concerns about the elevated risk of radiation-associated SPMs. ...Males were more likely to develop …
BACKGROUND: Second primary malignancies (SPMs) account for over 30% of total deaths in head and neck cancer (HNC) patients. The incre …
3,136 results