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Single-cell and spatial transcriptomics reveal SPRR2A(+) epithelial-MMP1(+) fibroblast interactions as key drivers of Esophageal Squamous Cell Carcinoma progression.
Yang W, Chen Y, Wang F, Chen W, Xiao X, Ma R, Kang D. Yang W, et al. Int J Biol Macromol. 2026 Oct;377:152654. doi: 10.1016/j.ijbiomac.2026.152654. Epub 2026 May 21. Int J Biol Macromol. 2026. PMID: 42173220 Free article.
Further trajectory analysis revealed that progenitor-like PLA2G2A(+) fibroblasts differentiate hierarchically into tumor-promoting ACTA2(+) and MMP1(+) subtypes. Notably, SPRR2A(+) epithelial cells and MMP1(+) fibroblasts exhibited pronounced spatial co-localization, which …
Further trajectory analysis revealed that progenitor-like PLA2G2A(+) fibroblasts differentiate hierarchically into tumor-promoting ACTA2(+) …
Comprehensive Genomic Profiling of Patient-matched Head and Neck Cancer Cells: A Preclinical Pipeline for Metastatic and Recurrent Disease.
Nisa L, Barras D, Medová M, Aebersold DM, Medo M, Poliaková M, Koch J, Bojaxhiu B, Eliçin O, Dettmer MS, Angelino P, Giger R, Borner U, Caversaccio MD, Carey TE, Ho L, McKee TA, Delorenzi M, Zimmer Y. Nisa L, et al. Mol Cancer Res. 2018 Dec;16(12):1912-1926. doi: 10.1158/1541-7786.MCR-18-0056. Epub 2018 Aug 14. Mol Cancer Res. 2018. PMID: 30108165 Free article.
Assessment of SPRR2A protein expression in a clinical cohort of patients with HNSCC confirmed common SPRR2A downregulation in primary tumors (61.9% of cases) and lymph node metastases (31.3%), but not in normal tissue. ...Underlining its discovery potential this app …
Assessment of SPRR2A protein expression in a clinical cohort of patients with HNSCC confirmed common SPRR2A downregulation in …
Decreased CSTA expression promotes lymphatic metastasis and predicts poor survival in oral squamous cell carcinoma.
Wang Y, Wang L, Li X, Qu X, Han N, Ruan M, Zhang C. Wang Y, et al. Arch Oral Biol. 2021 Jun;126:105116. doi: 10.1016/j.archoralbio.2021.105116. Epub 2021 Mar 31. Arch Oral Biol. 2021. PMID: 33831734
Eight hub genes - ALOXE3, CSTA, PLA2G4E, PPL, SPRR1A, SPRR2A, SPRR2D, and SPRR2E, were identified via WGCNA and PPI analyses. CSTA expression was markedly downregulated in primary OSCC tissues, and low CSTA expression significantly correlated with high tumor grade (P = 0. …
Eight hub genes - ALOXE3, CSTA, PLA2G4E, PPL, SPRR1A, SPRR2A, SPRR2D, and SPRR2E, were identified via WGCNA and PPI analyses. CSTA ex …
Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins.
Fang Z, Zhang S, Wang Y, Shen S, Wang F, Hao Y, Li Y, Zhang B, Zhou Y, Yang H. Fang Z, et al. BMC Cancer. 2016 Sep 1;16(1):706. doi: 10.1186/s12885-016-2735-x. BMC Cancer. 2016. PMID: 27586393 Free PMC article.
DNA microarray analysis showed that several members of small proline rich proteins (SPRR) were up-regulated by KD of MALAT-1 lncRNA in TSCC cells. SPRR2A over-expression could impair distant metastasis of TSCC cells in-vivo. CONCLUSION: Enhanced expression of MALAT-1 is as …
DNA microarray analysis showed that several members of small proline rich proteins (SPRR) were up-regulated by KD of MALAT-1 lncRNA in TSCC …
Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray.
Luo A, Kong J, Hu G, Liew CC, Xiong M, Wang X, Ji J, Wang T, Zhi H, Wu M, Liu Z. Luo A, et al. Oncogene. 2004 Feb 12;23(6):1291-9. doi: 10.1038/sj.onc.1207218. Oncogene. 2004. PMID: 14647409
Functional analysis of the alteration in the expression of GKLF suggested that GKLF might be able to regulate the expression of SPRR1A, SPRR2A and KRT4 in ESCC. This study provides new insights into the role of squamous cell differentiation-associated genes in ESCC initiat …
Functional analysis of the alteration in the expression of GKLF suggested that GKLF might be able to regulate the expression of SPRR1A, S …