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140 results

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Page 1
SR9009 inhibits lethal prostate cancer subtype 1 by regulating the LXRalpha/FOXM1 pathway independently of REV-ERBs.
Xu H, Zhang J, Zheng X, Tan P, Xiong X, Yi X, Yang Y, Wang Y, Liao D, Li H, Wei Q, Ai J, Yang L. Xu H, et al. Cell Death Dis. 2022 Nov 10;13(11):949. doi: 10.1038/s41419-022-05392-6. Cell Death Dis. 2022. PMID: 36357378 Free PMC article.
All of these genes were upregulated in PCa tissues, associated with worse clinicopathological outcomes and downregulated after SR9009 treatment. Nevertheless, knockdown or knockout of REV-ERB could not rescue the anticancer effect of SR9009 in PCa. Further analysis …
All of these genes were upregulated in PCa tissues, associated with worse clinicopathological outcomes and downregulated after SR9009 …
SR9009 improves heart function after pressure overload independent of cardiac REV-ERB.
Li H, Song S, Tien CL, Qi L, Graves A, Nasiotis E, Burris TP, Zhao Y, Sun Z, Zhang L. Li H, et al. Front Cardiovasc Med. 2022 Jul 14;9:952114. doi: 10.3389/fcvm.2022.952114. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35911512 Free PMC article.
However, it is unknown whether SR9009 indeed works through cardiac REV-ERB, given that SR9009 might target other proteins and that REV-ERB in non-cardiac tissues might regulate cardiac functions indirectly. ...Interestingly, the cardioprotective effect of SR9009 …
However, it is unknown whether SR9009 indeed works through cardiac REV-ERB, given that SR9009 might target other proteins and …
SR9009 has REV-ERB-independent effects on cell proliferation and metabolism.
Dierickx P, Emmett MJ, Jiang C, Uehara K, Liu M, Adlanmerini M, Lazar MA. Dierickx P, et al. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12147-12152. doi: 10.1073/pnas.1904226116. Epub 2019 May 24. Proc Natl Acad Sci U S A. 2019. PMID: 31127047 Free PMC article.
However, the direct involvement of REV-ERBs in these effects of SR9009 has not been thoroughly assessed, as experiments were not performed in the complete absence of both proteins. ...Thus, the effects of SR9009 cannot be used solely as surrogate for REV-ERB activit …
However, the direct involvement of REV-ERBs in these effects of SR9009 has not been thoroughly assessed, as experiments were not perf …
SR9009 attenuates TGF-beta1-induced renal fibrotic responses by inhibiting the NOX4/p38 signaling pathway in NRK-49F cells.
Takaguri A, Shinohe S, Noro R, Sakuraba M, Satoh C, Ohashi R, Satoh K. Takaguri A, et al. Eur J Pharmacol. 2025 Jan 15;987:177162. doi: 10.1016/j.ejphar.2024.177162. Epub 2024 Dec 1. Eur J Pharmacol. 2025. PMID: 39626804
However, the impact of SR9009 on renal fibrosis remains largely unevaluated. In this study, we investigated the effects of SR9009 on transforming growth factor (TGF)-beta1-induced fibrotic responses and elucidated the mechanisms involved. ...In conclusion, SR9009 …
However, the impact of SR9009 on renal fibrosis remains largely unevaluated. In this study, we investigated the effects of SR9009 …
SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1beta pathway.
Huang ZN, Wang J, Wang ZY, Min LY, Ni HL, Han YL, Tian YY, Cui YZ, Han JX, Cheng XF. Huang ZN, et al. iScience. 2024 Apr 16;27(5):109733. doi: 10.1016/j.isci.2024.109733. eCollection 2024 May 17. iScience. 2024. PMID: 38689641 Free PMC article.
Here, we first confirmed that NR1D1 in the nucleus pulposus tissue presents periodic rhythmic changes and decreases in expression with intervertebral disc degeneration. Second, when NR1D1 was activated by SR9009 in vitro, NLRP3 inflammasome assembly and IL-1beta production …
Here, we first confirmed that NR1D1 in the nucleus pulposus tissue presents periodic rhythmic changes and decreases in expression with inter …
SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis.
Hu M, Zhang L, Cao J, Jiang Y, Liu G. Hu M, et al. Can Respir J. 2022 Jul 1;2022:5802938. doi: 10.1155/2022/5802938. eCollection 2022. Can Respir J. 2022. PMID: 35814267 Free PMC article.
The inflammatory response is obviously enhanced in LPS-constructed sepsis mice and alleviated by SR9009 agonist treatment. Cell-based experiments reveal that pharmacological activation of Rev-Erbalpha via SR9009 attenuates the LPS-induced inflammatory response by su …
The inflammatory response is obviously enhanced in LPS-constructed sepsis mice and alleviated by SR9009 agonist treatment. Cell-based …
REV-ERBalpha Agonist SR9009 Promotes a Negative Energy Balance in Goldfish.
Saiz N, Herrera-Castillo L, Isorna E, Delgado MJ, Conde-Sieira M, Soengas JL, de Pedro N. Saiz N, et al. Int J Mol Sci. 2022 Mar 8;23(6):2921. doi: 10.3390/ijms23062921. Int J Mol Sci. 2022. PMID: 35328345 Free PMC article.
Moreover, SR9009 decreased plasma glucose, coinciding with increased glycolysis and a decreased gluconeogenesis in the liver. Decreased triglyceride levels and activity of lipogenic enzymes suggest a lipogenesis reduction by SR9009. Energy expenditure by locomotor a …
Moreover, SR9009 decreased plasma glucose, coinciding with increased glycolysis and a decreased gluconeogenesis in the liver. Decreas …
SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy.
Shen W, Zhang W, Ye W, Wang H, Zhang Q, Shen J, Hong Q, Li X, Wen G, Wei T, Zhang J. Shen W, et al. Theranostics. 2020 Mar 15;10(10):4466-4480. doi: 10.7150/thno.42478. eCollection 2020. Theranostics. 2020. PMID: 32292508 Free PMC article.
Autophagy regulation by REV-ERBalpha and its possible mechanism in SR9009-based SCLC therapy were analyzed. Results: Here, we showed that the REV-ERB agonist SR9009 is specifically lethal to both chemosensitive and chemoresistant SCLC cells. REV-ERBalpha was involve …
Autophagy regulation by REV-ERBalpha and its possible mechanism in SR9009-based SCLC therapy were analyzed. Results: Here, we showed …
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Yu F, Wang Z, Zhang T, Chen X, Xu H, Wang F, Guo L, Chen M, Liu K, Wu B. Yu F, et al. Nat Commun. 2021 Sep 7;12(1):5323. doi: 10.1038/s41467-021-25674-5. Nat Commun. 2021. PMID: 34493722 Free PMC article.
Moreover, small-molecule targeting of REV-ERBalpha/BMAL1 by SR9009 ameliorates HFD-induced obesity in mice. Altogether, intestine clock functions as an accelerator in dietary fat absorption and targeting intestinal BMAL1 may be a promising approach for management of metabo …
Moreover, small-molecule targeting of REV-ERBalpha/BMAL1 by SR9009 ameliorates HFD-induced obesity in mice. Altogether, intestine clo …
140 results