An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation.
Xie Y, Zhu S, Chen L, Liu H, Peng T, Ming Z, Zou Z, Hu X, Luo W, Peng K, Nie Y, Luo T, Ma D, Liu S, Luo Z.
Xie Y, et al.
Cancers (Basel). 2023 Apr 23;15(9):2424. doi: 10.3390/cancers15092424.
Cancers (Basel). 2023.
PMID: 37173892
Free PMC article.
RESULTS: By combining the unique structures of the natural compounds STA-21 and Aulosirazole with antitumor activities, we synthesized a class of novel isoxazoloquinone derivatives and showed that one of these compounds, ZSW, binds to the SH2 domain of STAT3, leadin …
RESULTS: By combining the unique structures of the natural compounds STA-21 and Aulosirazole with antitumor activities, we syn …