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2007 4
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330 results

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Page 1
STAT3 Hyper-IgE Syndrome-an Update and Unanswered Questions.
Tsilifis C, Freeman AF, Gennery AR. Tsilifis C, et al. J Clin Immunol. 2021 Jul;41(5):864-880. doi: 10.1007/s10875-021-01051-1. Epub 2021 May 1. J Clin Immunol. 2021. PMID: 33932191 Free PMC article. Review.
The hyper-IgE syndromes (HIES) are a heterogeneous group of inborn errors of immunity sharing manifestations including increased infection susceptibility, eczema, and raised serum IgE. ...In this review we summarize the published literature on STAT3-HI …
The hyper-IgE syndromes (HIES) are a heterogeneous group of inborn errors of immunity sharing manifestations including increas …
Hyper-IgE syndrome, 2021 update.
Minegishi Y. Minegishi Y. Allergol Int. 2021 Oct;70(4):407-414. doi: 10.1016/j.alit.2021.07.007. Epub 2021 Aug 18. Allergol Int. 2021. PMID: 34419355 Free article. Review.
We previously identified that major causal variants of the hyper-IgE syndrome are dominant negative variants in the STAT3. In addition to the identification of new causative variants for the disorders similar to the original hyper-IgE …
We previously identified that major causal variants of the hyper-IgE syndrome are dominant negative variants in the …
Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases.
Sutanto H, Adytia GJ, Fetarayani D. Sutanto H, et al. Curr Allergy Asthma Rep. 2025 Mar 14;25(1):17. doi: 10.1007/s11882-025-01196-8. Curr Allergy Asthma Rep. 2025. PMID: 40082265 Review.
PURPOSE OF REVIEW: It seeks to answer key questions about the molecular and cellular mechanisms underlying Hyper IgE Syndrome (HIES), the genetic mutations responsible, and their contributions to both immunodeficiency and allergic manifestations. ...RE …
PURPOSE OF REVIEW: It seeks to answer key questions about the molecular and cellular mechanisms underlying Hyper IgE Syndro …
Hyper IgE Syndromes.
Gracci S, Novelli T, D'Elios S, Bernardini R, Peroni D. Gracci S, et al. Curr Pediatr Rev. 2024;20(3):253-264. doi: 10.2174/1573396320666230912103124. Curr Pediatr Rev. 2024. PMID: 37702167
The Hyper IgE Syndromes are rare primary immunodeficiencies characterized by eczema, recurrent skin and respiratory infections and elevated serum IgE levels. Nowadays a geneticmolecular characterization is possible and allows the distinction in various monoge …
The Hyper IgE Syndromes are rare primary immunodeficiencies characterized by eczema, recurrent skin and respiratory infections …
Hyper-IgE syndrome update.
Sowerwine KJ, Holland SM, Freeman AF. Sowerwine KJ, et al. Ann N Y Acad Sci. 2012 Feb;1250:25-32. doi: 10.1111/j.1749-6632.2011.06387.x. Epub 2012 Jan 23. Ann N Y Acad Sci. 2012. PMID: 22268731 Free PMC article. Review.
Autosomal dominant hyper-IgE syndrome (AD-HIES) or Job's syndrome is a primary immunodeficiency with a wide array of clinical features caused by dominant negative mutations in STAT3. ...
Autosomal dominant hyper-IgE syndrome (AD-HIES) or Job's syndrome is a primary immunodeficiency with a wi …
The hyper-IgE syndromes.
Freeman AF, Holland SM. Freeman AF, et al. Immunol Allergy Clin North Am. 2008 May;28(2):277-91, viii. doi: 10.1016/j.iac.2008.01.005. Immunol Allergy Clin North Am. 2008. PMID: 18424333 Free PMC article. Review.
The hyper IgE syndromes (HIES) are rare primary immune deficiencies characterized by elevated serum IgE, rash, and recurrent bacterial infections of the skin and lung. Autosomal dominant HIES, the most common disease in this group, results from STAT3 …
The hyper IgE syndromes (HIES) are rare primary immune deficiencies characterized by elevated serum IgE, rash, and recu …
[Hyper-IgE syndromes].
He YY, Liu B, Xiao XP. He YY, et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 5;31(11):892-896. doi: 10.13201/j.issn.1001-1781.2017.11.019. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017. PMID: 29775011 Review. Chinese.
A hyper-IgE syndrome is a rare immunodeficiesncy disease, often accompanied by high serum IgE. ...This article reviews the clinical manifestations, pathogenesis and treatment of high IgE syndrome....
A hyper-IgE syndrome is a rare immunodeficiesncy disease, often accompanied by high serum IgE. ...This article r …
STAT3 haploinsufficiency is associated with autosomal dominant hyper-IgE syndrome.
Andreani V, Forde AJ, Fliegauf M, Bressan G, Noé V, Ott N, Saghafi S, Vornholz L, Isay SE, Ruland J, Henneke P, Grimbacher B. Andreani V, et al. Sci Adv. 2025 Aug 29;11(35):eadw2464. doi: 10.1126/sciadv.adw2464. Epub 2025 Aug 29. Sci Adv. 2025. PMID: 40880472 Free PMC article.
The autosomal dominant hyper-IgE syndrome (AD-HIES) is a primary immunodeficiency, which originates from heterozygous missense mutations in the signal transducer and activator of transcription 3 (STAT3) gene. ...To explore STAT3 he …
The autosomal dominant hyper-IgE syndrome (AD-HIES) is a primary immunodeficiency, which originates from heterozygous m …
Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations.
Sun L, Walls SA, Dang H, Quinney NL, Sears PR, Sadritabrizi T, Hasegawa K, Okuda K, Asakura T, Chang X, Zheng M, Mikami Y, Dizmond FU, Danilova D, Zhou L, Deshmukh A, Cholon DM, Radicioni G, Rogers TD, Kissner WJ, Markovetz MR, Guhr Lee TN, Gutay MI, Esther CR, Chua M, Grubb BR, Ehre C, Kesimer M, Hill DB, Ostrowski LE, Button B, Gentzsch M, Robinson C, Olivier KN, Freeman AF, Randell SH, O'Neal WK, Boucher RC, Chen G. Sun L, et al. bioRxiv [Preprint]. 2024 Aug 15:2024.08.14.607930. doi: 10.1101/2024.08.14.607930. bioRxiv. 2024. PMID: 39211176 Free PMC article. Preprint.
RATIONALE: Hyper IgE syndrome (STAT3-HIES), also known as Job's syndrome, is a rare immunodeficiency disease typically caused by dominant-negative STAT3 mutations. ...OBJECTIVES: To identify airway epithelial host defense de …
RATIONALE: Hyper IgE syndrome (STAT3-HIES), also known as Job's syndrome, is a rare immunodeficien …
Hyper-IgE syndrome.
Minegishi Y. Minegishi Y. Curr Opin Immunol. 2009 Oct;21(5):487-92. doi: 10.1016/j.coi.2009.07.013. Epub 2009 Aug 28. Curr Opin Immunol. 2009. PMID: 19717292 Review.
Hyper-IgE syndrome (HIES) is a complex primary immunodeficiency characterized by atopic dermatitis associated with extremely high serum IgE levels and susceptibility to infections with extracellular bacteria. ...Recent studies have demonstrated that do …
Hyper-IgE syndrome (HIES) is a complex primary immunodeficiency characterized by atopic dermatitis associated with extr …
330 results