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1996 1
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1,741 results

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Page 1
Genetic Predisposition to Colorectal Cancer: How Many and Which Genes to Test?
Rebuzzi F, Ulivi P, Tedaldi G. Rebuzzi F, et al. Int J Mol Sci. 2023 Jan 21;24(3):2137. doi: 10.3390/ijms24032137. Int J Mol Sci. 2023. PMID: 36768460 Free PMC article. Review.
However, some other genetic disorders confer an increased risk of colorectal cancer, such as Li-Fraumeni syndrome (TP53 gene), MUTYH-associated polyposis (MUTYH gene), Peutz-Jeghers syndrome (STK11 gene), Cowden syndrome (PTEN gene), and juvenil …
However, some other genetic disorders confer an increased risk of colorectal cancer, such as Li-Fraumeni syndrome (TP53 gene), MUTYH- …
Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status.
Ricciuti B, Arbour KC, Lin JJ, Vajdi A, Vokes N, Hong L, Zhang J, Tolstorukov MY, Li YY, Spurr LF, Cherniack AD, Recondo G, Lamberti G, Wang X, Venkatraman D, Alessi JV, Vaz VR, Rizvi H, Egger J, Plodkowski AJ, Khosrowjerdi S, Digumarthy S, Park H, Vaz N, Nishino M, Sholl LM, Barbie D, Altan M, Heymach JV, Skoulidis F, Gainor JF, Hellmann MD, Awad MM. Ricciuti B, et al. J Thorac Oncol. 2022 Mar;17(3):399-410. doi: 10.1016/j.jtho.2021.10.013. Epub 2021 Nov 2. J Thorac Oncol. 2022. PMID: 34740862 Free PMC article.
INTRODUCTION: STK11 and KEAP1 mutations (STK11 mutant [STK11(MUT)] and KEAP1(MUT)) are among the most often mutated genes in lung adenocarcinoma (LUAD). ...Tumors harboring concurrent KRAS/STK11 and KRAS/KEAP1 mutations display distinct immune p …
INTRODUCTION: STK11 and KEAP1 mutations (STK11 mutant [STK11(MUT)] and KEAP1(MUT)) are among the most often mutated …
Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy.
Skoulidis F, Heymach JV. Skoulidis F, et al. Nat Rev Cancer. 2019 Sep;19(9):495-509. doi: 10.1038/s41568-019-0179-8. Epub 2019 Aug 12. Nat Rev Cancer. 2019. PMID: 31406302 Free PMC article. Review.
The impressive clinical activity of small-molecule receptor tyrosine kinase inhibitors for oncogene-addicted subgroups of non-small-cell lung cancer (for example, those driven by activating mutations in the gene encoding epidermal growth factor receptor (EGFR) or rearrange …
The impressive clinical activity of small-molecule receptor tyrosine kinase inhibitors for oncogene-addicted subgroups of non-small-cell lun …
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.
Wohlhieter CA, Richards AL, Uddin F, Hulton CH, Quintanal-Villalonga À, Martin A, de Stanchina E, Bhanot U, Asher M, Shah NS, Hayatt O, Buonocore DJ, Rekhtman N, Shen R, Arbour KC, Donoghue M, Poirier JT, Sen T, Rudin CM. Wohlhieter CA, et al. Cell Rep. 2020 Dec 1;33(9):108444. doi: 10.1016/j.celrep.2020.108444. Cell Rep. 2020. PMID: 33264619 Free PMC article.
STK11/KEAP1 co-mutation results in significantly elevated expression of ferroptosis-protective genes, including SCD and AKR1C1/2/3, and resistance to pharmacologically induced ferroptosis. CRISPR screening further nominates SCD (SCD1) as selectively essential in
STK11/KEAP1 co-mutation results in significantly elevated expression of ferroptosis-protective genes, including SCD and AKR1C1
Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.
Altamish M, Dahiya R, Singh AK, Mishra A, Aljabali AAA, Satija S, Mehta M, Dureja H, Prasher P, Negi P, Kapoor DN, Goyal R, Tambuwala MM, Chellappan DK, Dua K, Gupta G. Altamish M, et al. Crit Rev Eukaryot Gene Expr. 2020;30(3):245-252. doi: 10.1615/CritRevEukaryotGeneExpr.2020033451. Crit Rev Eukaryot Gene Expr. 2020. PMID: 32749111 Review.
PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 …
PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in assoc …
Genetics of breast cancer: a topic in evolution.
Shiovitz S, Korde LA. Shiovitz S, et al. Ann Oncol. 2015 Jul;26(7):1291-9. doi: 10.1093/annonc/mdv022. Epub 2015 Jan 20. Ann Oncol. 2015. PMID: 25605744 Free PMC article. Review.
However, in patients with a suggestive personal and/or family history, a specific predisposing gene is identified in <30% of cases. Up to 25% of hereditary cases are due to a mutation in one of the few identified rare, but highly penetrant genes (BRCA1, BRCA2, PT …
However, in patients with a suggestive personal and/or family history, a specific predisposing gene is identified in <30% of cases …
Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer.
Tong X, Patel AS, Kim E, Li H, Chen Y, Li S, Liu S, Dilly J, Kapner KS, Zhang N, Xue Y, Hover L, Mukhopadhyay S, Sherman F, Myndzar K, Sahu P, Gao Y, Li F, Li F, Fang Z, Jin Y, Gao J, Shi M, Sinha S, Chen L, Chen Y, Kheoh T, Yang W, Yanai I, Moreira AL, Velcheti V, Neel BG, Hu L, Christensen JG, Olson P, Gao D, Zhang MQ, Aguirre AJ, Wong KK, Ji H. Tong X, et al. Cancer Cell. 2024 Mar 11;42(3):413-428.e7. doi: 10.1016/j.ccell.2024.01.012. Epub 2024 Feb 22. Cancer Cell. 2024. PMID: 38402609 Free article.
In lung patients with adenocarcinoma with KRAS(G12C) and STK11/LKB1 co-mutations, we find an enrichment of the squamous cell carcinoma gene signature in pre-treatment biopsies correlates with a poor response to adagrasib. ...
In lung patients with adenocarcinoma with KRAS(G12C) and STK11/LKB1 co-mutations, we find an enrichment of the squamous cell carcinom …
Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.
Yurgelun MB, Allen B, Kaldate RR, Bowles KR, Judkins T, Kaushik P, Roa BB, Wenstrup RJ, Hartman AR, Syngal S. Yurgelun MB, et al. Gastroenterology. 2015 Sep;149(3):604-13.e20. doi: 10.1053/j.gastro.2015.05.006. Epub 2015 May 14. Gastroenterology. 2015. PMID: 25980754 Free PMC article.
We investigated the number of cancer predisposition gene mutations identified by parallel sequencing in individuals with suspected Lynch syndrome. ...An additional 9 individuals carried mutations in other genes linked to high lifetime risks of cancer (5 had mutation …
We investigated the number of cancer predisposition gene mutations identified by parallel sequencing in individuals with suspected Ly …
STK11 gene analysis reveals a significant number of splice mutations in Chinese PJS patients.
Jiang YL, Zhao ZY, Li BR, Wang H, Yu ED, Ning SB. Jiang YL, et al. Cancer Genet. 2019 Jan;230:47-57. doi: 10.1016/j.cancergen.2018.11.008. Epub 2018 Nov 30. Cancer Genet. 2019. PMID: 30528796
BACKGROUND: The combination of direct sequencing and multiple ligation-dependent probe amplification (MLPA) has resulted in an 80% detection rate of serine/threonine kinase 11 (STK11) gene mutations in Peutz-Jeghers syndrome (PJS); however, this rate varies in diffe …
BACKGROUND: The combination of direct sequencing and multiple ligation-dependent probe amplification (MLPA) has resulted in an 80% detection …
Expression of STK11 gene and its promoter activity in MCF control and cancer cells.
Alkaf A, Al-Jafari A, Wani TA, Alqattan S, Zargar S. Alkaf A, et al. 3 Biotech. 2017 Dec;7(6):362. doi: 10.1007/s13205-017-1000-6. Epub 2017 Oct 4. 3 Biotech. 2017. PMID: 29043114 Free PMC article.
Serine/threonine kinase gene (STK11) is identified as tumor suppressor gene whose mutation can lead to Peutz-Jeghers syndrome (PJS). ...Positive correlation was observed in promoter activity and gene expression (p = 0.048, r(2) = 0.587). This study for …
Serine/threonine kinase gene (STK11) is identified as tumor suppressor gene whose mutation can lead to Peutz-Jeghers sy …
1,741 results