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6,840 results

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Page 1
SUMO: From Bench to Bedside.
Chang HM, Yeh ETH. Chang HM, et al. Physiol Rev. 2020 Oct 1;100(4):1599-1619. doi: 10.1152/physrev.00025.2019. Physiol Rev. 2020. PMID: 32666886 Free PMC article. Review.
There are three major SUMOs. SUMO-1 usually modifies a substrate as a monomer; however, SUMO-2/3 can form poly-SUMO chains. The monomeric SUMO-1 or poly-SUMO chains can interact with other proteins through SUMO-interactive motif (SIM). .. …
There are three major SUMOs. SUMO-1 usually modifies a substrate as a monomer; however, SUMO-2/3 can form poly-SUMO cha …
SUMO Interacting Motifs: Structure and Function.
Yau TY, Sander W, Eidson C, Courey AJ. Yau TY, et al. Cells. 2021 Oct 21;10(11):2825. doi: 10.3390/cells10112825. Cells. 2021. PMID: 34831049 Free PMC article. Review.
Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins. Once covalently conjugated to a protein, SUMO often reg …
Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function t …
SUMO-SIM interactions: From structure to biological functions.
Lascorz J, Codina-Fabra J, Reverter D, Torres-Rosell J. Lascorz J, et al. Semin Cell Dev Biol. 2022 Dec;132:193-202. doi: 10.1016/j.semcdb.2021.11.007. Epub 2021 Nov 25. Semin Cell Dev Biol. 2022. PMID: 34840078 Review.
The vast majority of these interactions involve a conserved surface in the SUMO protein and a SUMO interacting motif (SIM), a short stretch of hydrophobic amino acids and an acidic region, in the interactor protein. ...Moreover, SUMO-SIM interactions are ubiq …
The vast majority of these interactions involve a conserved surface in the SUMO protein and a SUMO interacting motif (SIM), a …
When SUMO met splicing.
Pozzi B, Mammi P, Bragado L, Giono LE, Srebrow A. Pozzi B, et al. RNA Biol. 2018;15(6):689-695. doi: 10.1080/15476286.2018.1457936. Epub 2018 May 9. RNA Biol. 2018. PMID: 29741121 Free PMC article. Review.
Spliceosomal proteins have been revealed as SUMO conjugation targets. Moreover, we have reported that many of these are in a SUMO-conjugated form when bound to a pre-mRNA substrate during a splicing reaction. ...We posit that SUMO conjugation could represent …
Spliceosomal proteins have been revealed as SUMO conjugation targets. Moreover, we have reported that many of these are in a SUMO …
SUMO and cellular adaptive mechanisms.
Ryu HY, Ahn SH, Hochstrasser M. Ryu HY, et al. Exp Mol Med. 2020 Jun;52(6):931-939. doi: 10.1038/s12276-020-0457-2. Epub 2020 Jun 26. Exp Mol Med. 2020. PMID: 32591648 Free PMC article. Review.
The ubiquitin family member SUMO is a covalent regulator of proteins that functions in response to various stresses, and defects in SUMO-protein conjugation or deconjugation have been implicated in multiple diseases. The loss of the Ulp2 SUMO protease, which …
The ubiquitin family member SUMO is a covalent regulator of proteins that functions in response to various stresses, and defects in …
The SUMO components in rheumatoid arthritis.
Wu Q, Jiang Y, You C. Wu Q, et al. Rheumatology (Oxford). 2022 Nov 28;61(12):4619-4630. doi: 10.1093/rheumatology/keac297. Rheumatology (Oxford). 2022. PMID: 35595244
To date, certain SUMO components, including SUMO-1, SUMO-2/3, SAE1/Uba2, Ubc9, PIASs (protein inhibitors of activated signal transducer and activator of transcription) and SENPs (SUMO-specific proteases), have been found to participate in the pathogene …
To date, certain SUMO components, including SUMO-1, SUMO-2/3, SAE1/Uba2, Ubc9, PIASs (protein inhibitors of activated s …
SUMO in Drosophila Development.
Cao J, Courey AJ. Cao J, et al. Adv Exp Med Biol. 2017;963:249-257. doi: 10.1007/978-3-319-50044-7_15. Adv Exp Med Biol. 2017. PMID: 28197917 Review.
In some cases, conjugation of SUMO to a target protein inhibits its normal activity, while in other cases SUMO conjugation stimulates target protein activity. SUMO often modulates a biological process by altering the subcellular localization of a target prote …
In some cases, conjugation of SUMO to a target protein inhibits its normal activity, while in other cases SUMO conjugation sti …
SUMO conjugation regulates immune signalling.
Hegde S, Soory A, Kaduskar B, Ratnaparkhi GS. Hegde S, et al. Fly (Austin). 2020 Mar-Dec;14(1-4):62-79. doi: 10.1080/19336934.2020.1808402. Epub 2020 Aug 31. Fly (Austin). 2020. PMID: 32777975 Free PMC article. Review.
In this review, we explore functional roles for one such PTM, the small ubiquitin-like modifier (SUMO). Very few of the SUMO conjugation targets identified by proteomic studies have been validated in terms of their roles in host defence. ...We discuss, using the few …
In this review, we explore functional roles for one such PTM, the small ubiquitin-like modifier (SUMO). Very few of the SUMO c …
The SUMO Pathway.
Martín-Rufo R, Gómez-Moya A, Lecona E. Martín-Rufo R, et al. Methods Mol Biol. 2025;2957:1-15. doi: 10.1007/978-1-0716-4710-3_1. Methods Mol Biol. 2025. PMID: 40875111 Review.
Here we dissect the biochemistry behind protein SUMOylation, and we describe the specific characteristics of SUMO that set it apart from the ubiquitin pathway. We cover the machinery involved in SUMO maturation, its conjugation (writers), and removal (erasers), as w …
Here we dissect the biochemistry behind protein SUMOylation, and we describe the specific characteristics of SUMO that set it apart f …
How Does SUMO Participate in Spindle Organization?
Abrieu A, Liakopoulos D. Abrieu A, et al. Cells. 2019 Jul 31;8(8):801. doi: 10.3390/cells8080801. Cells. 2019. PMID: 31370271 Free PMC article. Review.
Of particular interest is the ability of SUMO to organize proteins in larger assemblies, as well as the role of SUMO-dependent ubiquitylation in their disassembly. ...Finally, we propose future directions regarding the study of SUMOylation in regulation of spindle o …
Of particular interest is the ability of SUMO to organize proteins in larger assemblies, as well as the role of SUMO-dependent …
6,840 results