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mTOR and cancer: insights into a complex relationship.
Sabatini DM. Sabatini DM. Nat Rev Cancer. 2006 Sep;6(9):729-34. doi: 10.1038/nrc1974. Epub 2006 Aug 17. Nat Rev Cancer. 2006. PMID: 16915295 Review.
Microarrays of cells expressing defined cDNAs.
Ziauddin J, Sabatini DM. Ziauddin J, et al. Among authors: sabatini dm. Nature. 2001 May 3;411(6833):107-10. doi: 10.1038/35075114. Nature. 2001. PMID: 11333987
Enumeration of the simian virus 40 early region elements necessary for human cell transformation.
Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA. Hahn WC, et al. Among authors: sabatini dm. Mol Cell Biol. 2002 Apr;22(7):2111-23. doi: 10.1128/mcb.22.7.2111-2123.2002. Mol Cell Biol. 2002. PMID: 11884599 Free PMC article.
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation.
Peng T, Golub TR, Sabatini DM. Peng T, et al. Among authors: sabatini dm. Mol Cell Biol. 2002 Aug;22(15):5575-84. doi: 10.1128/mcb.22.15.5575-5584.2002. Mol Cell Biol. 2002. PMID: 12101249 Free PMC article.
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5. Cell. 2002. PMID: 12150925
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Mol Cell. 2003 Apr;11(4):895-904. doi: 10.1016/s1097-2765(03)00114-x. Mol Cell. 2003. PMID: 12718876
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.
Schalm SS, Fingar DC, Sabatini DM, Blenis J. Schalm SS, et al. Among authors: sabatini dm. Curr Biol. 2003 May 13;13(10):797-806. doi: 10.1016/s0960-9822(03)00329-4. Curr Biol. 2003. PMID: 12747827
Raptor and mTOR: subunits of a nutrient-sensitive complex.
Kim DH, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Curr Top Microbiol Immunol. 2004;279:259-70. doi: 10.1007/978-3-642-18930-2_15. Curr Top Microbiol Immunol. 2004. PMID: 14560962 Review.
Systematic genome-wide screens of gene function.
Carpenter AE, Sabatini DM. Carpenter AE, et al. Among authors: sabatini dm. Nat Rev Genet. 2004 Jan;5(1):11-22. doi: 10.1038/nrg1248. Nat Rev Genet. 2004. PMID: 14708012 Review. No abstract available.
Huntingtin aggregates ask to be eaten.
Thoreen CC, Sabatini DM. Thoreen CC, et al. Among authors: sabatini dm. Nat Genet. 2004 Jun;36(6):553-4. doi: 10.1038/ng0604-553. Nat Genet. 2004. PMID: 15167929 No abstract available.
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