Sabatini DM - Search Results

1

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.

Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Wan M, et al. Among authors: sabatini dm. Cell Metab. 2011 Oct 5;14(4):516-27. doi: 10.1016/j.cmet.2011.09.001. Cell Metab. 2011. PMID: 21982711 Free PMC article.

2

Defining the role of mTOR in cancer.

Guertin DA, Sabatini DM. Guertin DA, et al. Among authors: sabatini dm. Cancer Cell. 2007 Jul;12(1):9-22. doi: 10.1016/j.ccr.2007.05.008. Cancer Cell. 2007. PMID: 17613433 Free article. Review.

3

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. Peterson TR, et al. Among authors: sabatini dm. Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14. Cell. 2009. PMID: 19446321 Free PMC article.

4

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.

Sengupta S, Peterson TR, Sabatini DM. Sengupta S, et al. Among authors: sabatini dm. Mol Cell. 2010 Oct 22;40(2):310-22. doi: 10.1016/j.molcel.2010.09.026. Mol Cell. 2010. PMID: 20965424 Free PMC article. Review.

5

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. Peterson TR, et al. Among authors: sabatini dm. Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034. Cell. 2011. PMID: 21816276 Free PMC article.

6

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. Guertin DA, et al. Among authors: sabatini dm. Dev Cell. 2006 Dec;11(6):859-71. doi: 10.1016/j.devcel.2006.10.007. Dev Cell. 2006. PMID: 17141160 Free article.

7

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003. Mol Cell. 2007. PMID: 17386266 Free article.

8

An expanding role for mTOR in cancer.

Guertin DA, Sabatini DM. Guertin DA, et al. Among authors: sabatini dm. Trends Mol Med. 2005 Aug;11(8):353-61. doi: 10.1016/j.molmed.2005.06.007. Trends Mol Med. 2005. PMID: 16002336 Review.

9

The pharmacology of mTOR inhibition.

Guertin DA, Sabatini DM. Guertin DA, et al. Among authors: sabatini dm. Sci Signal. 2009 Apr 21;2(67):pe24. doi: 10.1126/scisignal.267pe24. Sci Signal. 2009. PMID: 19383975

10

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. Sengupta S, et al. Among authors: sabatini dm. Nature. 2010 Dec 23;468(7327):1100-4. doi: 10.1038/nature09584. Nature. 2010. PMID: 21179166

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