Sabatini DM - Search Results

1

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. Robida-Stubbs S, et al. Among authors: sabatini dm. Cell Metab. 2012 May 2;15(5):713-24. doi: 10.1016/j.cmet.2012.04.007. Cell Metab. 2012. PMID: 22560223 Free PMC article.

2

Increased mTORC1 signaling UPRegulates stress.

Reiling JH, Sabatini DM. Reiling JH, et al. Among authors: sabatini dm. Mol Cell. 2008 Mar 14;29(5):533-5. doi: 10.1016/j.molcel.2008.02.011. Mol Cell. 2008. PMID: 18342598 Free article.

3

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8. Cell. 2010. PMID: 20381137 Free PMC article.

4

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

Yip CK, Murata K, Walz T, Sabatini DM, Kang SA. Yip CK, et al. Among authors: sabatini dm. Mol Cell. 2010 Jun 11;38(5):768-74. doi: 10.1016/j.molcel.2010.05.017. Mol Cell. 2010. PMID: 20542007 Free PMC article.

5

A radical role for TOR in longevity.

Lamming DW, Sabatini DM. Lamming DW, et al. Among authors: sabatini dm. Cell Metab. 2011 Jun 8;13(6):617-8. doi: 10.1016/j.cmet.2011.05.006. Cell Metab. 2011. PMID: 21641542 Free PMC article.

6

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. Peterson TR, et al. Among authors: sabatini dm. Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034. Cell. 2011. PMID: 21816276 Free PMC article.

7

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.

Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Wan M, et al. Among authors: sabatini dm. Cell Metab. 2011 Oct 5;14(4):516-27. doi: 10.1016/j.cmet.2011.09.001. Cell Metab. 2011. PMID: 21982711 Free PMC article.

8

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Lamming DW, et al. Among authors: sabatini dm. Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135. Science. 2012. PMID: 22461615 Free PMC article.

9

mTOR signaling in growth control and disease.

Laplante M, Sabatini DM. Laplante M, et al. Among authors: sabatini dm. Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017. Cell. 2012. PMID: 22500797 Free PMC article. Review.

10

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM. Yilmaz ÖH, et al. Among authors: sabatini dm. Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163. Nature. 2012. PMID: 22722868 Free PMC article.

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