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Page 1
Cyclization of Ynamide-Tethered 1,3,8-Triynes.
Sabbasani VR, Lee H, Xie P, Xia Y, Lee D. Sabbasani VR, et al. Chemistry. 2017 Jun 16;23(34):8161-8165. doi: 10.1002/chem.201701781. Epub 2017 May 29. Chemistry. 2017. PMID: 28431205
Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Lu X, Sabbasani VR, Osei-Amponsa V, Evans CN, King JC, Tarasov SG, Dyba M, Das S, Chan KC, Schwieters CD, Choudhari S, Fromont C, Zhao Y, Tran B, Chen X, Matsuo H, Andresson T, Chari R, Swenson RE, Tarasova NI, Walters KJ. Lu X, et al. Among authors: sabbasani vr. Nat Commun. 2021 Dec 16;12(1):7318. doi: 10.1038/s41467-021-27570-4. Nat Commun. 2021. PMID: 34916494 Free PMC article.
Bifunctional small molecules that mediate the degradation of extracellular proteins.
Caianiello DF, Zhang M, Ray JD, Howell RA, Swartzel JC, Branham EMJ, Chirkin E, Sabbasani VR, Gong AZ, McDonald DM, Muthusamy V, Spiegel DA. Caianiello DF, et al. Among authors: sabbasani vr. Nat Chem Biol. 2021 Sep;17(9):947-953. doi: 10.1038/s41589-021-00851-1. Epub 2021 Aug 19. Nat Chem Biol. 2021. PMID: 34413525