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The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment.
Czarnota-Łydka K, Kucwaj-Brysz K, Mordyl B, Głuch-Lutwin M, Karcz T, Jastrzębska-Więsek M, Partyka A, Dąbrowska M, Satała G, Sudoł-Tałaj S, Brunetti L, de Candia M, Purgatorio R, Cerini M, Piemontese L, Podlewska S, Latacz G, Starek M, Wesołowska A, Carrieri A, Handzlik J. Czarnota-Łydka K, et al. Among authors: podlewska s. Eur J Med Chem. 2025 Nov 15;298:118026. doi: 10.1016/j.ejmech.2025.118026. Epub 2025 Aug 5. Eur J Med Chem. 2025. PMID: 40774068 Free article.
Unlocking the potential of higher-molecular-weight 5-HT7R ligands: Synthesis, affinity, and ADMET examination.
Pyka P, Garbo S, Murzyn A, Satała G, Janusz A, Górka M, Pietruś W, Mituła F, Popiel D, Wieczorek M, Palmisano B, Raucci A, Bojarski AJ, Zwergel C, Szymańska E, Kucwaj-Brysz K, Battistelli C, Handzlik J, Podlewska S. Pyka P, et al. Among authors: podlewska s. Bioorg Chem. 2024 Oct;151:107668. doi: 10.1016/j.bioorg.2024.107668. Epub 2024 Jul 24. Bioorg Chem. 2024. PMID: 39079393 Free article.
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Pyka P, Haberek W, Więcek M, Szymanska E, Ali W, Cios A, Jastrzębska-Więsek M, Satała G, Podlewska S, Di Giacomo S, Di Sotto A, Garbo S, Karcz T, Lambona C, Marocco F, Latacz G, Sudoł-Tałaj S, Mordyl B, Głuch-Lutwin M, Siwek A, Czarnota-Łydka K, Gogola D, Olejarz-Maciej A, Wilczyńska-Zawal N, Honkisz-Orzechowska E, Starek M, Dąbrowska M, Kucwaj-Brysz K, Fioravanti R, Nasim MJ, Hittinger M, Partyka A, Wesołowska A, Battistelli C, Zwergel C, Handzlik J. Pyka P, et al. Among authors: podlewska s. J Med Chem. 2024 Jan 25;67(2):1580-1610. doi: 10.1021/acs.jmedchem.3c02148. Epub 2024 Jan 8. J Med Chem. 2024. PMID: 38190615 Free PMC article.
53 results