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Human Trop-2 is a tumor-associated calcium signal transducer.
Ripani E, Sacchetti A, Corda D, Alberti S. Ripani E, et al. Among authors: sacchetti a. Int J Cancer. 1998 May 29;76(5):671-6. doi: 10.1002/(sici)1097-0215(19980529)76:5<671::aid-ijc10>3.0.co;2-7. Int J Cancer. 1998. PMID: 9610724
Trop-2/EGP-1/GA733-1 is a recently identified cell surface glycoprotein highly expressed by human carcinomas. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. ...Our …
Trop-2/EGP-1/GA733-1 is a recently identified cell surface glycoprotein highly expressed by human carcinomas. The cytoplasmic tail of …
Trop-2 Induces Tumor Growth Through AKT and Determines Sensitivity to AKT Inhibitors.
Guerra E, Trerotola M, Tripaldi R, Aloisi AL, Simeone P, Sacchetti A, Relli V, D'Amore A, La Sorda R, Lattanzio R, Piantelli M, Alberti S. Guerra E, et al. Among authors: sacchetti a. Clin Cancer Res. 2016 Aug 15;22(16):4197-205. doi: 10.1158/1078-0432.CCR-15-1701. Epub 2016 Mar 28. Clin Cancer Res. 2016. PMID: 27022065
PURPOSE: Inhibition of AKT is a key target area for personalized cancer medicine. However, predictive markers of response to AKT inhibitors are lacking. ...CONCLUSIONS: Our findings indicate that the expression of Trop-2 is a stringent predictor of tumor response to …
PURPOSE: Inhibition of AKT is a key target area for personalized cancer medicine. However, predictive markers of response to AKT inhi …
Caffeic acid phenethyl ester blocks apoptosis induced by low potassium in cerebellar granule cells.
Amodio R, De Ruvo C, Sacchetti A, Di Santo A, Martelli N, Di Matteo V, Lorenzet R, Poggi A, Rotilio D, Cacchio M, Esposito E. Amodio R, et al. Among authors: sacchetti a. Int J Dev Neurosci. 2003 Nov;21(7):379-89. doi: 10.1016/s0736-5748(03)00090-x. Int J Dev Neurosci. 2003. PMID: 14599484
Primary cultures of cerebellar granule neurons (CGNs) were prepared from 8-day-old Wistar rats, and maintained in an appropriate medium containing a high (25 mM) concentration of KCl. ...Since there is evidence that an increased formation of reactive oxygen species (ROS) i …
Primary cultures of cerebellar granule neurons (CGNs) were prepared from 8-day-old Wistar rats, and maintained in an appropriate medium cont …
Green fluorescent protein variants fold differentially in prokaryotic and eukaryotic cells.
Sacchetti A, Cappetti V, Marra P, Dell'Arciprete R, El Sewedy T, Crescenzi C, Alberti S. Sacchetti A, et al. J Cell Biochem Suppl. 2001;Suppl 36:117-28. doi: 10.1002/jcb.1091. J Cell Biochem Suppl. 2001. PMID: 11455577
The specificity of this differential folding supports a role of chaperones in guiding the folding of GFP in vivo. J. Cell. Biochem. ...
The specificity of this differential folding supports a role of chaperones in guiding the folding of GFP in vivo. J. Cell. Biochem. . …
Release of the mitogen lysophosphatidylinositol from H-Ras-transformed fibroblasts; a possible mechanism of autocrine control of cell proliferation.
Falasca M, Iurisci C, Carvelli A, Sacchetti A, Corda D. Falasca M, et al. Among authors: sacchetti a. Oncogene. 1998 May 7;16(18):2357-65. doi: 10.1038/sj.onc.1201758. Oncogene. 1998. PMID: 9620553
Lysophosphatidylinositol (LysoPtdIns) is formed by a constitutively-active phosphoinositide-specific phospholipase A2 in Ras-transformed cells and can stimulate cell proliferation. ...
Lysophosphatidylinositol (LysoPtdIns) is formed by a constitutively-active phosphoinositide-specific phospholipase A2 in Ras-transfor …
The molecular determinants of the efficiency of green fluorescent protein mutants.
Sacchetti A, Ciccocioppo R, Alberti S. Sacchetti A, et al. Histol Histopathol. 2000 Jan;15(1):101-7. doi: 10.14670/HH-15.101. Histol Histopathol. 2000. PMID: 10668201 Review.
The Green Fluorescent Protein (GFP) is a spontaneously fluorescent polypeptide of 27 kD from the jellyfish Aequorea victoria that absorbs UV-blue light and emits in the green region of the spectrum. ...
The Green Fluorescent Protein (GFP) is a spontaneously fluorescent polypeptide of 27 kD from the jellyfish Aequorea victoria that abs …
IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden.
van der Zee M, Sacchetti A, Cansoy M, Joosten R, Teeuwssen M, Heijmans-Antonissen C, Ewing-Graham PC, Burger CW, Blok LJ, Fodde R. van der Zee M, et al. Among authors: sacchetti a. Cancer Res. 2015 Sep 1;75(17):3608-22. doi: 10.1158/0008-5472.CAN-14-2498. Epub 2015 Jun 30. Cancer Res. 2015. PMID: 26130650
Given evidence of its role as a CSC marker, we hypothesized that high level of ALDH activity (ALDH(hi)) in a tumor might positively correlate with the presence of stem- and progenitor-like tumor cells in this disease setting. ...Overall, our results provide a
Given evidence of its role as a CSC marker, we hypothesized that high level of ALDH activity (ALDH(hi)) in a tumor might posit …
Protein tags enhance GFP folding in eukaryotic cells.
Sacchetti A, Alberti S. Sacchetti A, et al. Nat Biotechnol. 1999 Nov;17(11):1046. doi: 10.1038/14990. Nat Biotechnol. 1999. PMID: 10545870 No abstract available.
Oligomerization of DsRed is required for the generation of a functional red fluorescent chromophore.
Sacchetti A, Subramaniam V, Jovin TM, Alberti S. Sacchetti A, et al. FEBS Lett. 2002 Aug 14;525(1-3):13-9. doi: 10.1016/s0014-5793(02)02874-0. FEBS Lett. 2002. PMID: 12163153
These findings demonstrate that 'red' chromophores form and are functional only as oligomers, and suggest that the smallest red fluorescent functional unit is a dimer. A comparison of alkali-, acid- and guanidinium-denatured DsRed indicates that stabilization of the …
These findings demonstrate that 'red' chromophores form and are functional only as oligomers, and suggest that the smallest red fluorescent …
Efficient GFP mutations profoundly affect mRNA transcription and translation rates.
Sacchetti A, El Sewedy T, Nasr AF, Alberti S. Sacchetti A, et al. FEBS Lett. 2001 Mar 9;492(1-2):151-5. doi: 10.1016/s0014-5793(01)02246-3. FEBS Lett. 2001. PMID: 11248254
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