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The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.
Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR Jr. Banerjee A, et al. Among authors: sacchettini jc. Microbiology. 1998 Oct;144 ( Pt 10):2697-704. doi: 10.1099/00221287-144-10-2697. Microbiology. 1998. PMID: 9802011
Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue.
Gopaul DN, Meyer SL, Degano M, Sacchettini JC, Schramm VL. Gopaul DN, et al. Among authors: sacchettini jc. Biochemistry. 1996 May 14;35(19):5963-70. doi: 10.1021/bi952998u. Biochemistry. 1996. PMID: 8634237
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
Quémard A, Sacchettini JC, Dessen A, Vilcheze C, Bittman R, Jacobs WR Jr, Blanchard JS. Quémard A, et al. Among authors: sacchettini jc. Biochemistry. 1995 Jul 4;34(26):8235-41. doi: 10.1021/bi00026a004. Biochemistry. 1995. PMID: 7599116
The structure and function of the isoniazid target in M. tuberculosis.
Sacchettini JC, Blanchard JS. Sacchettini JC, et al. Res Microbiol. 1996 Jan-Feb;147(1-2):36-43. doi: 10.1016/0923-2508(96)80201-4. Res Microbiol. 1996. PMID: 8761720 Review. No abstract available.
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Dessen A, Quémard A, Blanchard JS, Jacobs WR Jr, Sacchettini JC. Dessen A, et al. Among authors: sacchettini jc. Science. 1995 Mar 17;267(5204):1638-41. doi: 10.1126/science.7886450. Science. 1995. PMID: 7886450
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG. McKinney JD, et al. Among authors: sacchettini jc. Nature. 2000 Aug 17;406(6797):735-8. doi: 10.1038/35021074. Nature. 2000. PMID: 10963599
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.
Vilchèze C, Morbidoni HR, Weisbrod TR, Iwamoto H, Kuo M, Sacchettini JC, Jacobs WR Jr. Vilchèze C, et al. Among authors: sacchettini jc. J Bacteriol. 2000 Jul;182(14):4059-67. doi: 10.1128/jb.182.14.4059-4067.2000. J Bacteriol. 2000. PMID: 10869086 Free PMC article.
Mechanisms for isoniazid action and resistance.
Miesel L, Rozwarski DA, Sacchettini JC, Jacobs WR Jr. Miesel L, et al. Among authors: sacchettini jc. Novartis Found Symp. 1998;217:209-20; discussion 220-1. doi: 10.1002/0470846526.ch15. Novartis Found Symp. 1998. PMID: 9949810 Review.
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