Sacco MD - Search Results

1

A unique class of Zn²⁺-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.

Sacco MD, Wang S, Adapa SR, Zhang X, Lewandowski EM, Gongora MV, Keramisanou D, Atlas ZD, Townsend JA, Gatdula JR, Morgan RT, Hammond LR, Marty MT, Wang J, Eswara PJ, Gelis I, Jiang RHY, Sun X, Chen Y. Sacco MD, et al. Nat Commun. 2022 Jul 28;13(1):4370. doi: 10.1038/s41467-022-32086-6. Nat Commun. 2022. PMID: 35902581 Free PMC article.

2

Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.

Kroeck KG, Sacco MD, Smith EW, Zhang X, Shoun D, Akhtar A, Darch SE, Cohen F, Andrews LD, Knox JE, Chen Y. Kroeck KG, et al. Among authors: sacco md. Sci Rep. 2019 Oct 29;9(1):15450. doi: 10.1038/s41598-019-51844-z. Sci Rep. 2019. PMID: 31664082 Free PMC article.

3

Influence of the α-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 β-Lactamase.

Sacco MD, Kroeck KG, Kemp MT, Zhang X, Andrews LD, Chen Y. Sacco MD, et al. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01473-19. doi: 10.1128/AAC.01473-19. Print 2019 Dec 20. Antimicrob Agents Chemother. 2019. PMID: 31685462 Free PMC article.

4

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.

Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Ma C, et al. Among authors: sacco md. bioRxiv [Preprint]. 2020 Jan 6:2020.04.20.051581. doi: 10.1101/2020.04.20.051581. bioRxiv. 2020. PMID: 32511378 Free PMC article. Updated. Preprint.

5

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.

Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Ma C, et al. Among authors: sacco md. Cell Res. 2020 Aug;30(8):678-692. doi: 10.1038/s41422-020-0356-z. Epub 2020 Jun 15. Cell Res. 2020. PMID: 32541865 Free PMC article.

6

Interdependent YpsA- and YfhS-Mediated Cell Division and Cell Size Phenotypes in Bacillus subtilis.

Brzozowski RS, Tomlinson BR, Sacco MD, Chen JJ, Ali AN, Chen Y, Shaw LN, Eswara PJ. Brzozowski RS, et al. Among authors: sacco md. mSphere. 2020 Jul 22;5(4):e00655-20. doi: 10.1128/mSphere.00655-20. mSphere. 2020. PMID: 32699122 Free PMC article.

7

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M^pro and cathepsin L.

Sacco MD, Ma C, Lagarias P, Gao A, Townsend JA, Meng X, Dube P, Zhang X, Hu Y, Kitamura N, Hurst B, Tarbet B, Marty MT, Kolocouris A, Xiang Y, Chen Y, Wang J. Sacco MD, et al. bioRxiv [Preprint]. 2020 Jul 27:2020.07.27.223727. doi: 10.1101/2020.07.27.223727. bioRxiv. 2020. PMID: 32766590 Free PMC article. Updated. Preprint.

8

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M^pro and cathepsin L.

Sacco MD, Ma C, Lagarias P, Gao A, Townsend JA, Meng X, Dube P, Zhang X, Hu Y, Kitamura N, Hurst B, Tarbet B, Marty MT, Kolocouris A, Xiang Y, Chen Y, Wang J. Sacco MD, et al. Sci Adv. 2020 Dec 9;6(50):eabe0751. doi: 10.1126/sciadv.abe0751. Print 2020 Dec. Sci Adv. 2020. PMID: 33158912 Free PMC article.

9

Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay.

Xia Z, Sacco MD, Ma C, Townsend JA, Kitamura N, Hu Y, Ba M, Szeto T, Zhang X, Meng X, Zhang F, Xiang Y, Marty MT, Chen Y, Wang J. Xia Z, et al. Among authors: sacco md. bioRxiv [Preprint]. 2021 Mar 16:2021.03.15.435551. doi: 10.1101/2021.03.15.435551. bioRxiv. 2021. PMID: 33758866 Free PMC article. Updated. Preprint.

10

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.

Kitamura N, Sacco MD, Ma C, Hu Y, Townsend JA, Meng X, Zhang F, Zhang X, Ba M, Szeto T, Kukuljac A, Marty MT, Schultz D, Cherry S, Xiang Y, Chen Y, Wang J. Kitamura N, et al. Among authors: sacco md. J Med Chem. 2022 Feb 24;65(4):2848-2865. doi: 10.1021/acs.jmedchem.1c00509. Epub 2021 Apr 23. J Med Chem. 2022. PMID: 33891389 Free PMC article.

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