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Diaryl dihydropyrazole-3-carboxamides with significant in vivo antiobesity activity related to CB1 receptor antagonism: synthesis, biological evaluation, and molecular modeling in the homology model.
Srivastava BK, Joharapurkar A, Raval S, Patel JZ, Soni R, Raval P, Gite A, Goswami A, Sadhwani N, Gandhi N, Patel H, Mishra B, Solanki M, Pandey B, Jain MR, Patel PR. Srivastava BK, et al. Among authors: sadhwani n. J Med Chem. 2007 Nov 29;50(24):5951-66. doi: 10.1021/jm061490u. Epub 2007 Nov 3. J Med Chem. 2007. PMID: 17979261
Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole.
Srivastava BK, Soni R, Joharapurkar A, Sairam KV, Patel JZ, Goswami A, Shedage SA, Kar SS, Salunke RP, Gugale SB, Dhawas A, Kadam P, Mishra B, Sadhwani N, Unadkat VB, Mitra P, Jain MR, Patel PR. Srivastava BK, et al. Among authors: sadhwani n. Bioorg Med Chem Lett. 2008 Feb 1;18(3):963-8. doi: 10.1016/j.bmcl.2007.12.036. Epub 2007 Dec 23. Bioorg Med Chem Lett. 2008. PMID: 18207393
Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist.
Kumar Srivastava B, Soni R, Patel JZ, Jha S, Shedage SA, Gandhi N, Sairam KV, Pawar V, Sadhwani N, Mitra P, Jain MR, Patel PR. Kumar Srivastava B, et al. Among authors: sadhwani n. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3882-6. doi: 10.1016/j.bmcl.2008.06.045. Epub 2008 Jun 18. Bioorg Med Chem Lett. 2008. PMID: 18585913
Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.
Srivastava BK, Soni R, Patel JZ, Joharapurkar A, Sadhwani N, Kshirsagar S, Mishra B, Takale V, Gupta S, Pandya P, Kapadnis P, Solanki M, Patel H, Mitra P, Jain MR, Patel PR. Srivastava BK, et al. Among authors: sadhwani n. Bioorg Med Chem Lett. 2009 May 1;19(9):2546-50. doi: 10.1016/j.bmcl.2009.03.046. Epub 2009 Mar 17. Bioorg Med Chem Lett. 2009. PMID: 19328683
18 results