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Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment.
Ulland TK, Jain N, Hornick EE, Elliott EI, Clay GM, Sadler JJ, Mills KA, Janowski AM, Volk AP, Wang K, Legge KL, Gakhar L, Bourdi M, Ferguson PJ, Wilson ME, Cassel SL, Sutterwala FS. Ulland TK, et al. Among authors: sadler jj. Nat Commun. 2016 Oct 25;7:13180. doi: 10.1038/ncomms13180. Nat Commun. 2016. PMID: 27779193 Free PMC article.
The Nalp3 inflammasome is essential for the development of silicosis.
Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. Cassel SL, et al. Among authors: sadler jj. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9035-40. doi: 10.1073/pnas.0803933105. Epub 2008 Jun 24. Proc Natl Acad Sci U S A. 2008. PMID: 18577586 Free PMC article.
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.
Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS. Iyer SS, et al. Among authors: sadler jj. Immunity. 2013 Aug 22;39(2):311-323. doi: 10.1016/j.immuni.2013.08.001. Epub 2013 Aug 15. Immunity. 2013. PMID: 23954133 Free PMC article.
Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo.
Ciraci C, Janczy JR, Jain N, Haasken S, Pecli E Silva C, Benjamim CF, Sadler JJ, Olivier AK, Iwakura Y, Shayakhmetov DM, Sutterwala FS, Cassel SL. Ciraci C, et al. Among authors: sadler jj. PLoS One. 2016 Mar 15;11(3):e0151252. doi: 10.1371/journal.pone.0151252. eCollection 2016. PLoS One. 2016. PMID: 26978520 Free PMC article.
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome.
Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. Iyer SS, et al. Among authors: sadler jj. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20388-93. doi: 10.1073/pnas.0908698106. Epub 2009 Nov 16. Proc Natl Acad Sci U S A. 2009. PMID: 19918053 Free PMC article.
Functional hierarchy of the N-terminal tyrosines of SLP-76.
Jordan MS, Sadler J, Austin JE, Finkelstein LD, Singer AL, Schwartzberg PL, Koretzky GA. Jordan MS, et al. J Immunol. 2006 Feb 15;176(4):2430-8. doi: 10.4049/jimmunol.176.4.2430. J Immunol. 2006. PMID: 16456002
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