Saei AA - Search Results

1

System-wide identification and prioritization of enzyme substrates by thermal analysis.

Saei AA, Beusch CM, Sabatier P, Wells JA, Gharibi H, Meng Z, Chernobrovkin A, Rodin S, Näreoja K, Thorsell AG, Karlberg T, Cheng Q, Lundström SL, Gaetani M, Végvári Á, Arnér ESJ, Schüler H, Zubarev RA. Saei AA, et al. Nat Commun. 2021 Feb 26;12(1):1296. doi: 10.1038/s41467-021-21540-6. Nat Commun. 2021. PMID: 33637753 Free PMC article.

2

Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions.

Saei AA, Sabatier P, Tokat ÜG, Chernobrovkin A, Pirmoradian M, Zubarev RA. Saei AA, et al. Mol Cell Proteomics. 2018 Jun;17(6):1144-1155. doi: 10.1074/mcp.RA118.000610. Epub 2018 Mar 23. Mol Cell Proteomics. 2018. PMID: 29572246 Free PMC article.

3

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.

Zhang X, Pellegrini P, Saei AA, Hillert EK, Mazurkiewicz M, Olofsson MH, Zubarev RA, D'Arcy P, Linder S. Zhang X, et al. Among authors: saei aa. Biochem Pharmacol. 2018 Oct;156:291-301. doi: 10.1016/j.bcp.2018.08.039. Epub 2018 Aug 25. Biochem Pharmacol. 2018. PMID: 30149015

4

Dynamic Proteomics Reveals High Plasticity of Cellular Proteome: Growth-Related and Drug-Induced Changes in Cancer Cells are Comparable.

Sabatier P, Saei AA, Wang S, Zubarev RA. Sabatier P, et al. Among authors: saei aa. Proteomics. 2018 Dec;18(24):e1800118. doi: 10.1002/pmic.201800118. Epub 2018 Nov 30. Proteomics. 2018. PMID: 30382632

5

Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.

Hillert EK, Brnjic S, Zhang X, Mazurkiewicz M, Saei AA, Mofers A, Selvaraju K, Zubarev R, Linder S, D'Arcy P. Hillert EK, et al. Among authors: saei aa. Cancer Lett. 2019 Apr 28;448:70-83. doi: 10.1016/j.canlet.2019.02.003. Epub 2019 Feb 13. Cancer Lett. 2019. PMID: 30768956

6

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.

Zhang X, Selvaraju K, Saei AA, D'Arcy P, Zubarev RA, Arnér ES, Linder S. Zhang X, et al. Among authors: saei aa. Biochimie. 2019 Jul;162:46-54. doi: 10.1016/j.biochi.2019.03.015. Epub 2019 Apr 1. Biochimie. 2019. PMID: 30946948 Free article.

7

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment.

Zhang X, Espinosa B, Saei AA, D'Arcy P, Zubarev RA, Linder S. Zhang X, et al. Among authors: saei aa. Oxid Med Cell Longev. 2019 Jun 10;2019:1659468. doi: 10.1155/2019/1659468. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31281566 Free PMC article.

8

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution.

Gaetani M, Sabatier P, Saei AA, Beusch CM, Yang Z, Lundström SL, Zubarev RA. Gaetani M, et al. Among authors: saei aa. J Proteome Res. 2019 Nov 1;18(11):4027-4037. doi: 10.1021/acs.jproteome.9b00500. Epub 2019 Oct 14. J Proteome Res. 2019. PMID: 31545609

9

ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery.

Saei AA, Beusch CM, Chernobrovkin A, Sabatier P, Zhang B, Tokat ÜG, Stergiou E, Gaetani M, Végvári Á, Zubarev RA. Saei AA, et al. Nat Commun. 2019 Dec 16;10(1):5715. doi: 10.1038/s41467-019-13582-8. Nat Commun. 2019. PMID: 31844049 Free PMC article.

10

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds.

Peuget S, Zhu J, Sanz G, Singh M, Gaetani M, Chen X, Shi Y, Saei AA, Visnes T, Lindström MS, Rihani A, Moyano-Galceran L, Carlson JW, Hjerpe E, Joneborg U, Lehti K, Hartman J, Helleday T, Zubarev R, Selivanova G. Peuget S, et al. Among authors: saei aa. Cancer Res. 2020 Apr 1;80(7):1538-1550. doi: 10.1158/0008-5472.CAN-19-2069. Epub 2020 Feb 4. Cancer Res. 2020. PMID: 32019870

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