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The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
Saez I, Vilchez D. Saez I, et al. Curr Genomics. 2014 Feb;15(1):38-51. doi: 10.2174/138920291501140306113344. Curr Genomics. 2014. PMID: 24653662 Free PMC article.
Mediation of organismal aging and somatic proteostasis by the germline.
Khodakarami A, Saez I, Mels J, Vilchez D. Khodakarami A, et al. Front Mol Biosci. 2015 Jan 23;2:3. doi: 10.3389/fmolb.2015.00003. eCollection 2015. Front Mol Biosci. 2015. PMID: 25988171 Free PMC article. Review.
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T. Rinschen MM, et al. Hum Mol Genet. 2016 Apr 1;25(7):1328-44. doi: 10.1093/hmg/ddw016. Epub 2016 Jan 19. Hum Mol Genet. 2016. PMID: 26792178 Free PMC article.
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.
Noormohammadi A, Khodakarami A, Gutierrez-Garcia R, Lee HJ, Koyuncu S, König T, Schindler C, Saez I, Fatima A, Dieterich C, Vilchez D. Noormohammadi A, et al. Nat Commun. 2016 Nov 28;7:13649. doi: 10.1038/ncomms13649. Nat Commun. 2016. PMID: 27892468 Free PMC article.
Insights into the ubiquitin-proteasome system of human embryonic stem cells.
Saez I, Koyuncu S, Gutierrez-Garcia R, Dieterich C, Vilchez D. Saez I, et al. Sci Rep. 2018 Mar 6;8(1):4092. doi: 10.1038/s41598-018-22384-9. Sci Rep. 2018. PMID: 29511261 Free PMC article.
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.
Koyuncu S, Saez I, Lee HJ, Gutierrez-Garcia R, Pokrzywa W, Fatima A, Hoppe T, Vilchez D. Koyuncu S, et al. Nat Commun. 2018 Jul 23;9(1):2886. doi: 10.1038/s41467-018-05320-3. Nat Commun. 2018. PMID: 30038412 Free PMC article.
The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
Kumsta C, Chang JT, Lee R, Tan EP, Yang Y, Loureiro R, Choy EH, Lim SHY, Saez I, Springhorn A, Hoppe T, Vilchez D, Hansen M. Kumsta C, et al. Among authors: saez i. Nat Commun. 2019 Dec 11;10(1):5648. doi: 10.1038/s41467-019-13540-4. Nat Commun. 2019. PMID: 31827090 Free PMC article.
Author Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.
Koyuncu S, Saez I, Lee HJ, Gutierrez-Garcia R, Pokrzywa W, Fatima A, Hoppe T, Vilchez D. Koyuncu S, et al. Among authors: saez i. Nat Commun. 2020 Feb 17;11(1):985. doi: 10.1038/s41467-020-14726-x. Nat Commun. 2020. PMID: 32066719 Free PMC article.
The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.
Saez I, Gerbracht JV, Koyuncu S, Lee HJ, Horn M, Kroef V, Denzel MS, Dieterich C, Gehring NH, Vilchez D. Saez I, et al. FEBS Lett. 2020 Jan;594(1):175-188. doi: 10.1002/1873-3468.13559. Epub 2019 Aug 8. FEBS Lett. 2020. PMID: 31365120
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