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Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.
Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP. Russell LK, et al. Among authors: saffitz je. Circ Res. 2004 Mar 5;94(4):525-33. doi: 10.1161/01.RES.0000117088.36577.EB. Epub 2004 Jan 15. Circ Res. 2004. PMID: 14726475
A novel mouse model of lipotoxic cardiomyopathy.
Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, Saffitz JE, Schaffer JE. Chiu HC, et al. Among authors: saffitz je. J Clin Invest. 2001 Apr;107(7):813-22. doi: 10.1172/JCI10947. J Clin Invest. 2001. PMID: 11285300 Free PMC article.
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. Leone TC, et al. Among authors: saffitz je. PLoS Biol. 2005 Apr;3(4):e101. doi: 10.1371/journal.pbio.0030101. Epub 2005 Mar 15. PLoS Biol. 2005. PMID: 15760270 Free PMC article.
Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.
Mancuso DJ, Han X, Jenkins CM, Lehman JJ, Sambandam N, Sims HF, Yang J, Yan W, Yang K, Green K, Abendschein DR, Saffitz JE, Gross RW. Mancuso DJ, et al. Among authors: saffitz je. J Biol Chem. 2007 Mar 23;282(12):9216-27. doi: 10.1074/jbc.M607307200. Epub 2007 Jan 9. J Biol Chem. 2007. PMID: 17213206 Free article.
Fatty acid synthase modulates homeostatic responses to myocardial stress.
Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW 2nd, Nichols CG, Semenkovich CF. Razani B, et al. Among authors: saffitz je. J Biol Chem. 2011 Sep 2;286(35):30949-30961. doi: 10.1074/jbc.M111.230508. Epub 2011 Jul 8. J Biol Chem. 2011. PMID: 21757749 Free PMC article.
313 results