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Sarcomas as a mise en abyme of mesenchymal stem cells: exploiting interrelationships for cell mediated anticancer therapy.
Burns JS, Safwat A, Grisendi G, Kassem M, Dominici M. Burns JS, et al. Cancer Lett. 2012 Dec 1;325(1):1-10. doi: 10.1016/j.canlet.2012.05.027. Epub 2012 May 29. Cancer Lett. 2012. PMID: 22659735 Review.
Diversely sourced and defined, mesenchymal stem cells (MSCs) may be the cells of sarcoma origin, evolve a CSC phenotype and/or contribute to tumor growth through inherent qualities for homing, neovascularization, paracrine cross-feeding, microvesicle secretion, cell fusion …
Diversely sourced and defined, mesenchymal stem cells (MSCs) may be the cells of sarcoma origin, evolve a CSC phenotype and/or contri …
Tumour microenvironment and radiation response in sarcomas originating from tumourigenic human mesenchymal stem cells.
D'Andrea FP, Safwat A, Burns JS, Kassem M, Horsman MR, Overgaard J. D'Andrea FP, et al. Int J Radiat Biol. 2012 Jun;88(6):457-65. doi: 10.3109/09553002.2012.683509. Epub 2012 May 8. Int J Radiat Biol. 2012. PMID: 22502876
BACKGROUND: Resistance to radiation therapy remains a serious impediment to cancer therapy. We previously reported heterogeneity for clonogenic survival when testing in vitro radiation resistance among single-cell derived clones from a human mesenchymal cancer stem …
BACKGROUND: Resistance to radiation therapy remains a serious impediment to cancer therapy. We previously reported heterogeneity for …
Tumourigenicity and radiation resistance of mesenchymal stem cells.
D'Andrea FP, Horsman MR, Kassem M, Overgaard J, Safwat A. D'Andrea FP, et al. Acta Oncol. 2012 May;51(5):669-79. doi: 10.3109/0284186X.2011.636752. Epub 2011 Dec 7. Acta Oncol. 2012. PMID: 22150078
Radiation resistance was measured using a clonogenic assay. Differences in gene expression between the two cell lines, both under nontreated and irradiated conditions, were assessed with microarrays (Affymetrix Human Exon 1.0 ST array). ...The first group may contribute to …
Radiation resistance was measured using a clonogenic assay. Differences in gene expression between the two cell lines, both under non …
Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance.
D'Andrea FP, Safwat A, Kassem M, Gautier L, Overgaard J, Horsman MR. D'Andrea FP, et al. Radiother Oncol. 2011 Jun;99(3):373-8. doi: 10.1016/j.radonc.2011.05.086. Epub 2011 Jun 29. Radiother Oncol. 2011. PMID: 21719135
BACKGROUND: Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. ...From a pool of 15 validated genes with altered expression in the CE8 clone, we found the enzyme nicotinamide N-methyltransferase (N …
BACKGROUND: Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. . …
TEDDI: radiotherapy delivery in deep inspiration for pediatric patients - a NOPHO feasibility study.
Lundgaard AY, Hjalgrim LL, Rechner LA, Josipovic M, Joergensen M, Aznar MC, Berthelsen AK, Borgwardt L, Johansen C, Loft A, Safwat A, Vaalavirta L, Specht L, Maraldo MV. Lundgaard AY, et al. Radiat Oncol. 2018 Mar 27;13(1):56. doi: 10.1186/s13014-018-1003-4. Radiat Oncol. 2018. PMID: 29587881 Free PMC article. Clinical Trial.
Also, the study aims to establish the compliance to DIBH and to determine the accuracy and reproducibility in a pediatric setting. ...Prior to any treatment, patients will undergo a DIBH training session followed by a diagnostic PET/CT- or CT-staging scan in …
Also, the study aims to establish the compliance to DIBH and to determine the accuracy and reproducibility in a pediatric setting. .. …
Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy.
Safwat A, Bentzen SM, Turesson I, Hendry JH. Safwat A, et al. Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):198-204. doi: 10.1016/s0360-3016(01)02690-6. Int J Radiat Oncol Biol Phys. 2002. PMID: 11777639
For each field, in each patient, a curve showing the grade of telangiectasia as a function of time was constructed. A measure of radioresponsiveness was obtained from the difference between the area under the curve (AUC) for a specific field in an indi …
For each field, in each patient, a curve showing the grade of telangiectasia as a function of time was constructed. A m …
Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy.
Aggerholm-Pedersen N, Demuth C, Safwat A, Meldgaard P, Kassem M, Sandahl Sorensen B. Aggerholm-Pedersen N, et al. Stem Cells Int. 2016;2016:9601493. doi: 10.1155/2016/9601493. Epub 2015 Dec 15. Stem Cells Int. 2016. PMID: 26788073 Free PMC article.
Cancer-initiating cells are considered a major contributor to this resistance. Methods. An immortalised nontransformed human stromal (mesenchymal) stem cell line hMSC-TERT4 and a transformed cell line hMSC-TERT20-CE8, known to form sarcoma-like tumours when implante …
Cancer-initiating cells are considered a major contributor to this resistance. Methods. An immortalised nontransformed human stromal …
The prognostic role of inflammation-scores on overall survival in lung cancer patients.
Sandfeld-Paulsen B, Meldgaard P, Sorensen BS, Safwat A, Aggerholm-Pedersen N. Sandfeld-Paulsen B, et al. Acta Oncol. 2019 Mar;58(3):371-376. doi: 10.1080/0284186X.2018.1546057. Epub 2019 Jan 11. Acta Oncol. 2019. PMID: 30632850
When comparing the scores, the optimized inflammation-scores CNG and ACBS led to a better and more balanced patient-allocation. In the early clinical stages I & II, the optimized scores could reveal a subgroup of patients with poorer survival that is similar to …
When comparing the scores, the optimized inflammation-scores CNG and ACBS led to a better and more balanced patient-allocation. In th …
A rare case of CD30(+), radiation-induced cutaneous angiosarcoma misdiagnosed as T-cell lymphoma.
Aggerholm-Pedersen N, Bærentzen S, Holmberg Jørgensen JP, Safwat A. Aggerholm-Pedersen N, et al. J Clin Oncol. 2011 May 1;29(13):e362-4. doi: 10.1200/JCO.2010.33.3641. Epub 2011 Feb 7. J Clin Oncol. 2011. PMID: 21300934 No abstract available.
Tumour burden and interleukin-2 dose affect the interaction between low-dose total body irradiation and interleukin 2.
Safwat A, Aggerholm N, Roitt I, Overgaard J, Hokland M. Safwat A, et al. Eur J Cancer. 2004 Jun;40(9):1412-7. doi: 10.1016/j.ejca.2004.01.037. Eur J Cancer. 2004. PMID: 15177501
Low-dose total body irradiation (LTBI) has a synergistic immune-mediated antitumour effect when used in combination with interleukin 2 (IL-2) in a murine metastatic malignant melanoma model. ...Groups of mice received no treatment, a single fraction of LTBI a …
Low-dose total body irradiation (LTBI) has a synergistic immune-mediated antitumour effect when used in combination with interleukin …
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