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CNS accumulation of regulatory B cells is VLA-4-dependent.
Lehmann-Horn K, Sagan SA, Winger RC, Spencer CM, Bernard CC, Sobel RA, Zamvil SS. Lehmann-Horn K, et al. Among authors: sagan sa. Neurol Neuroimmunol Neuroinflamm. 2016 Mar 9;3(2):e212. doi: 10.1212/NXI.0000000000000212. eCollection 2016 Apr. Neurol Neuroimmunol Neuroinflamm. 2016. PMID: 27027096 Free PMC article.
Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.
Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS. Schulze-Topphoff U, et al. Among authors: sagan sa. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4777-82. doi: 10.1073/pnas.1603907113. Epub 2016 Apr 13. Proc Natl Acad Sci U S A. 2016. PMID: 27078105 Free PMC article.
Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.
Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. Sagan SA, et al. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14781-14786. doi: 10.1073/pnas.1617859114. Epub 2016 Dec 8. Proc Natl Acad Sci U S A. 2016. PMID: 27940915 Free PMC article.
Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis.
Novak F, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Bystrup A, Byg KE, Johansen IS, Mittl K, Rowles W, Mcpolin K, Spencer C, Sagan S, Gerungan C, Wilson MR, Zamvil SS, Bove R, Sabatino JJ, Sejbaek T. Novak F, et al. Mult Scler Relat Disord. 2021 Nov;56:103251. doi: 10.1016/j.msard.2021.103251. Epub 2021 Sep 9. Mult Scler Relat Disord. 2021. PMID: 34571415 Free PMC article.
Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine-induced antibody and T cell immunity and function.
Sabatino JJ Jr, Mittl K, Rowles WM, McPolin K, Rajan JV, Laurie MT, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander JR, DeRisi JL, Hollenbach JA, Wilson MR, Zamvil SS, Bove R. Sabatino JJ Jr, et al. Among authors: sagan sa. JCI Insight. 2022 Feb 22;7(4):e156978. doi: 10.1172/jci.insight.156978. JCI Insight. 2022. PMID: 35030101 Free PMC article.
14 results