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The efficacy of siRNAs against hepatitis C virus is strongly influenced by structure and target site accessibility.
Sagan SM, Nasheri N, Luebbert C, Pezacki JP. Sagan SM, et al. Chem Biol. 2010 May 28;17(5):515-27. doi: 10.1016/j.chembiol.2010.04.011. Chem Biol. 2010. PMID: 20534349
Modulation of GB virus B RNA abundance by microRNA-122: dependence on and escape from microRNA-122 restriction.
Sagan SM, Sarnow P, Wilson JA. Sagan SM, et al. J Virol. 2013 Jul;87(13):7338-47. doi: 10.1128/JVI.00378-13. Epub 2013 Apr 24. J Virol. 2013. PMID: 23616647 Free PMC article.
Combating hepatitis C virus by targeting microRNA-122 using locked nucleic acids.
Machlin ES, Sarnow P, Sagan SM. Machlin ES, et al. Among authors: sagan sm. Curr Gene Ther. 2012 Aug;12(4):301-6. doi: 10.2174/156652312802083558. Curr Gene Ther. 2012. PMID: 22856605 Review.
Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex.
Machlin ES, Sarnow P, Sagan SM. Machlin ES, et al. Among authors: sagan sm. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3193-8. doi: 10.1073/pnas.1012464108. Epub 2011 Jan 10. Proc Natl Acad Sci U S A. 2011. PMID: 21220300 Free PMC article.
cis-Acting RNA elements in the hepatitis C virus RNA genome.
Sagan SM, Chahal J, Sarnow P. Sagan SM, et al. Virus Res. 2015 Aug 3;206:90-8. doi: 10.1016/j.virusres.2014.12.029. Epub 2015 Jan 7. Virus Res. 2015. PMID: 25576644 Free PMC article. Review.
Dissecting noncoding and pathogen RNA-protein interactomes.
Flynn RA, Martin L, Spitale RC, Do BT, Sagan SM, Zarnegar B, Qu K, Khavari PA, Quake SR, Sarnow P, Chang HY. Flynn RA, et al. Among authors: sagan sm. RNA. 2015 Jan;21(1):135-43. doi: 10.1261/rna.047803.114. Epub 2014 Nov 19. RNA. 2015. PMID: 25411354 Free PMC article.
Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122.
Sarnow P, Sagan SM. Sarnow P, et al. Among authors: sagan sm. Annu Rev Virol. 2016 Sep 29;3(1):309-332. doi: 10.1146/annurev-virology-110615-042409. Epub 2016 Aug 17. Annu Rev Virol. 2016. PMID: 27578438 Review.
Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism.
Lyn RK, Kennedy DC, Sagan SM, Blais DR, Rouleau Y, Pegoraro AF, Xie XS, Stolow A, Pezacki JP. Lyn RK, et al. Among authors: sagan sm. Virology. 2009 Nov 10;394(1):130-42. doi: 10.1016/j.virol.2009.08.022. Epub 2009 Sep 10. Virology. 2009. PMID: 19747705
Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus.
Pezacki JP, Sagan SM, Tonary AM, Rouleau Y, BĂ©langer S, Supekova L, Su AI. Pezacki JP, et al. Among authors: sagan sm. BMC Chem Biol. 2009 Jan 16;9:2. doi: 10.1186/1472-6769-9-2. BMC Chem Biol. 2009. PMID: 19149867 Free PMC article.
Design and screening of siRNAs against highly structured RNA targets.
Nasheri N, Pezacki JP, Sagan SM. Nasheri N, et al. Among authors: sagan sm. Methods Mol Biol. 2013;942:69-86. doi: 10.1007/978-1-62703-119-6_4. Methods Mol Biol. 2013. PMID: 23027046
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