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Relating particle formation to salt- and pH-dependent phase separation of non-native aggregates of alpha-chymotrypsinogen A.
Kroetsch AM, Sahin E, Wang HY, Krizman S, Roberts CJ. Kroetsch AM, et al. Among authors: sahin e. J Pharm Sci. 2012 Oct;101(10):3651-60. doi: 10.1002/jps.23264. Epub 2012 Jul 17. J Pharm Sci. 2012. PMID: 22806414
Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation.
Weiss WF 4th, Zhang A, Ivanova MI, Sahin E, Jordan JL, Fernandez EJ, Roberts CJ. Weiss WF 4th, et al. Among authors: sahin e. Biophys Chem. 2014 Jan;185:79-87. doi: 10.1016/j.bpc.2013.11.005. Epub 2013 Nov 28. Biophys Chem. 2014. PMID: 24374388 Free PMC article.
Coarse-grained model for colloidal protein interactions, B(22), and protein cluster formation.
Blanco MA, Sahin E, Robinson AS, Roberts CJ. Blanco MA, et al. Among authors: sahin e. J Phys Chem B. 2013 Dec 19;117(50):16013-28. doi: 10.1021/jp409300j. Epub 2013 Dec 10. J Phys Chem B. 2013. PMID: 24289039 Free PMC article.
Aggregation and pH-temperature phase behavior for aggregates of an IgG2 antibody.
Sahin E, Weiss WF 4th, Kroetsch AM, King KR, Kessler RK, Das TK, Roberts CJ. Sahin E, et al. J Pharm Sci. 2012 May;101(5):1678-87. doi: 10.1002/jps.23056. Epub 2012 Jan 13. J Pharm Sci. 2012. PMID: 22246657
Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.
Sahin E, Jordan JL, Spatara ML, Naranjo A, Costanzo JA, Weiss WF, Robinson AS, Fernandez EJ, Roberts CJ. Sahin E, et al. Biochemistry. 2011 Feb 8;50(5):628-39. doi: 10.1021/bi100978r. Epub 2011 Jan 13. Biochemistry. 2011. PMID: 21184609
Predicting solution aggregation rates for therapeutic proteins: approaches and challenges.
Roberts CJ, Das TK, Sahin E. Roberts CJ, et al. Among authors: sahin e. Int J Pharm. 2011 Oct 14;418(2):318-33. doi: 10.1016/j.ijpharm.2011.03.064. Epub 2011 Apr 8. Int J Pharm. 2011. PMID: 21497188
Reexamining protein-protein and protein-solvent interactions from Kirkwood-Buff analysis of light scattering in multi-component solutions.
Blanco MA, Sahin E, Li Y, Roberts CJ. Blanco MA, et al. Among authors: sahin e. J Chem Phys. 2011 Jun 14;134(22):225103. doi: 10.1063/1.3596726. J Chem Phys. 2011. PMID: 21682538 Free PMC article.
Predicting High-Concentration Interactions of Monoclonal Antibody Solutions: Comparison of Theoretical Approaches for Strongly Attractive Versus Repulsive Conditions.
Calero-Rubio C, Saluja A, Sahin E, Roberts CJ. Calero-Rubio C, et al. Among authors: sahin e. J Phys Chem B. 2019 Jul 11;123(27):5709-5720. doi: 10.1021/acs.jpcb.9b03779. Epub 2019 Jun 26. J Phys Chem B. 2019. PMID: 31241333
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