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Metabolism of amyloid-beta peptide and Alzheimer's disease.
Iwata N, Higuchi M, Saido TC. Iwata N, et al. Among authors: saido tc. Pharmacol Ther. 2005 Nov;108(2):129-48. doi: 10.1016/j.pharmthera.2005.03.010. Epub 2005 Aug 19. Pharmacol Ther. 2005. PMID: 16112736 Review.
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. Tomita T, et al. Among authors: saido tc. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2025-30. doi: 10.1073/pnas.94.5.2025. Proc Natl Acad Sci U S A. 1997. PMID: 9050898 Free PMC article.
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