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Immunology: Oxysterols hold T cells in check.
Glass CK, Saijo K. Glass CK, et al. Among authors: saijo k. Nature. 2008 Sep 4;455(7209):40-1. doi: 10.1038/455040a. Nature. 2008. PMID: 18769427 No abstract available.
The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.
Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. Klotz L, et al. Among authors: saijo k. J Exp Med. 2009 Sep 28;206(10):2079-89. doi: 10.1084/jem.20082771. Epub 2009 Sep 8. J Exp Med. 2009. PMID: 19737866 Free PMC article.
25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.
Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. Shibata N, et al. Among authors: saijo k. J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4. J Biol Chem. 2013. PMID: 24189069 Free PMC article.
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