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β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1.
Bridgewater D, Di Giovanni V, Cain JE, Cox B, Jakobson M, Sainio K, Rosenblum ND. Bridgewater D, et al. Among authors: sainio k. J Am Soc Nephrol. 2011 Apr;22(4):718-31. doi: 10.1681/ASN.2010050562. Epub 2011 Mar 24. J Am Soc Nephrol. 2011. PMID: 21436291 Free PMC article.
Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvönen ME, Perälä N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, de Angelis MH, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappalainen P. Saarikangas J, et al. Among authors: sainio k. J Cell Sci. 2011 Apr 15;124(Pt 8):1245-55. doi: 10.1242/jcs.082610. Epub 2011 Mar 15. J Cell Sci. 2011. PMID: 21406566 Free article.
Canonical WNT/beta-catenin signaling is required for ureteric branching.
Bridgewater D, Cox B, Cain J, Lau A, Athaide V, Gill PS, Kuure S, Sainio K, Rosenblum ND. Bridgewater D, et al. Among authors: sainio k. Dev Biol. 2008 May 1;317(1):83-94. doi: 10.1016/j.ydbio.2008.02.010. Epub 2008 Feb 21. Dev Biol. 2008. PMID: 18358465
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