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LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.
Tajan M, Batut A, Cadoudal T, Deleruyelle S, Le Gonidec S, Saint Laurent C, Vomscheid M, Wanecq E, Tréguer K, De Rocca Serra-Nédélec A, Vinel C, Marques MA, Pozzo J, Kunduzova O, Salles JP, Tauber M, Raynal P, Cavé H, Edouard T, Valet P, Yart A. Tajan M, et al. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4494-503. doi: 10.1073/pnas.1406107111. Epub 2014 Oct 6. Proc Natl Acad Sci U S A. 2014. PMID: 25288766 Free PMC article.
SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations.
Paccoud R, Saint-Laurent C, Piccolo E, Tajan M, Dortignac A, Pereira O, Le Gonidec S, Baba I, Gélineau A, Askia H, Branchereau M, Charpentier J, Personnaz J, Branka S, Auriau J, Deleruyelle S, Canouil M, Beton N, Salles JP, Tauber M, Weill J, Froguel P, Neel BG, Araki T, Heymes C, Burcelin R, Castan I, Valet P, Dray C, Gautier EL, Edouard T, Pradère JP, Yart A. Paccoud R, et al. Among authors: saint laurent c. Sci Transl Med. 2021 Apr 28;13(591):eabe2587. doi: 10.1126/scitranslmed.abe2587. Epub 2021 Apr 28. Sci Transl Med. 2021. PMID: 33910978
The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
Saint-Laurent C, Mazeyrie L, Tajan M, Paccoud R, Castan-Laurell I, Valet P, Edouard T, Pradère JP, Dray C, Yart A. Saint-Laurent C, et al. Biomedicines. 2022 Aug 31;10(9):2139. doi: 10.3390/biomedicines10092139. Biomedicines. 2022. PMID: 36140242 Free PMC article. Review.
20 results