Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

3,694 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1.
Kawai K, Saito A, Sudo T, Osada H. Kawai K, et al. Among authors: saito a. J Biochem. 2008 Jun;143(6):765-72. doi: 10.1093/jb/mvn027. Epub 2008 Feb 22. J Biochem. 2008. PMID: 18296712
These results suggest that the CPI domain may serve to form a certain conformation suitable for the association with p38. Furthermore, we showed that knockdown of p62 expression by siRNA led to impaired p38 phosphorylation only when HeLa cells were stimulated by cytokine. …
These results suggest that the CPI domain may serve to form a certain conformation suitable for the association with p38. Furthermore …
Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment.
Furumai R, Ito A, Ogawa K, Maeda S, Saito A, Nishino N, Horinouchi S, Yoshida M. Furumai R, et al. Among authors: saito a. Cancer Sci. 2011 May;102(5):1081-7. doi: 10.1111/j.1349-7006.2011.01904.x. Epub 2011 Mar 4. Cancer Sci. 2011. PMID: 21299717
Trichostatin A (TSA) and the cyclic tetrapeptide class inhibitor Ky-2 inhibit both lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production in rats and TNF-α-induced expression of inflammatory genes in HeLa cells. ...Trichostatin A did not inhibit degra …
Trichostatin A (TSA) and the cyclic tetrapeptide class inhibitor Ky-2 inhibit both lipopolysaccharide-induced tumor necrosis factor-α …
A p38 mitogen-activated protein kinase inhibitor screening method using growth recovery of Escherichia coli as an index.
Kawai K, Saito A, Sudo T, Osada H. Kawai K, et al. Among authors: saito a. Anal Biochem. 2009 May 1;388(1):128-33. doi: 10.1016/j.ab.2009.02.022. Epub 2009 Feb 25. Anal Biochem. 2009. PMID: 19248755
The p38 mitogen-activated protein (MAP) kinase is the central signaling molecule regulating the cellular response to a multitude of external stimuli. ...Here we established a simple inhibitor screening method for a human protein by using bacteria in combinati …
The p38 mitogen-activated protein (MAP) kinase is the central signaling molecule regulating the cellular response to a multitude of e …
Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase.
Saito A, Kawai K, Takayama H, Sudo T, Osada H. Saito A, et al. Chem Asian J. 2008 Sep 1;3(8-9):1607-12. doi: 10.1002/asia.200800099. Chem Asian J. 2008. PMID: 18637653
p38 mitogen-activated protein kinase (MAPK) is a member of the serine/threonine kinases and is activated in response to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. ...SPR imaging experiments using a new photoaffinity li …
p38 mitogen-activated protein kinase (MAPK) is a member of the serine/threonine kinases and is activated in response to stress stimul …
Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.
Ong EB, Watanabe N, Saito A, Futamura Y, Abd El Galil KH, Koito A, Najimudin N, Osada H. Ong EB, et al. Among authors: saito a. J Biol Chem. 2011 Apr 22;286(16):14049-56. doi: 10.1074/jbc.M110.185397. Epub 2011 Feb 28. J Biol Chem. 2011. PMID: 21357691 Free PMC article.
We determined its minimal pharmacophore through a structure-activity relationship study and produced more potent derivatives. ...Our findings exposed a targeting site on Vpr and delineated a convenient approach to explore other targeting sites on the protein …
We determined its minimal pharmacophore through a structure-activity relationship study and produced more potent derivatives. ...Our …
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.
Matsuyama A, Shimazu T, Sumida Y, Saito A, Yoshimatsu Y, Seigneurin-Berny D, Osada H, Komatsu Y, Nishino N, Khochbin S, Horinouchi S, Yoshida M. Matsuyama A, et al. Among authors: saito a. EMBO J. 2002 Dec 16;21(24):6820-31. doi: 10.1093/emboj/cdf682. EMBO J. 2002. PMID: 12486003 Free PMC article.
Trichostatin A (TSA) inhibits all histone deacetylases (HDACs) of both class I and II, whereas trapoxin (TPX) cannot inhibit HDAC6, a cytoplasmic member of class II HDACs. ...We therefore suggest that acetylation and deacetylation are coupled to the microtubule turn …
Trichostatin A (TSA) inhibits all histone deacetylases (HDACs) of both class I and II, whereas trapoxin (TPX) cannot inhibit HDAC6, …
Inhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-β1 (TGF-β1) administration suppresses osteoblast differentiation.
Ochiai H, Okada S, Saito A, Hoshi K, Yamashita H, Takato T, Azuma T. Ochiai H, et al. Among authors: saito a. J Biol Chem. 2012 Jun 29;287(27):22654-61. doi: 10.1074/jbc.M111.279091. Epub 2012 May 9. J Biol Chem. 2012. PMID: 22573330 Free PMC article.
We think this fact could open the way to use IGF-1 as a treatment tool for bone regeneration in prolonged inflammatory disease....
We think this fact could open the way to use IGF-1 as a treatment tool for bone regeneration in prolonged inflammatory disease....
In Silico Investigation of a HIV-1 Vpr Inhibitor Binding Site: Potential for Virtual Screening and anti-HIV Drug Design.
Choi SB, Choong YS, Saito A, Wahab HA, Najimudin N, Watanabe N, Osada H, Ong EB. Choi SB, et al. Among authors: saito a. Mol Inform. 2014 Dec;33(11-12):742-8. doi: 10.1002/minf.201400080. Epub 2014 Nov 25. Mol Inform. 2014. PMID: 27485420
HIV-1 Vpr, a multifunctional accessory protein involved in viral infection, replication and pathogenesis, is a potential target. ...To investigate our prediction of the inhibitors' binding site, we docked the coumarin inhibitors into the predicted hydrophobic bindin …
HIV-1 Vpr, a multifunctional accessory protein involved in viral infection, replication and pathogenesis, is a potential targe …
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.
Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, Takashima A. Soeda Y, et al. Among authors: saito a. Nat Commun. 2015 Dec 16;6:10216. doi: 10.1038/ncomms10216. Nat Commun. 2015. PMID: 26671725 Free PMC article.
Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with clinical progression of the disease. A growing body of evidence indicates that tau olig …
Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofi …
A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins.
Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Omagari K, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Sureau C, Wakita T. Tsukuda S, et al. Among authors: saito a. Hepatology. 2017 Apr;65(4):1104-1116. doi: 10.1002/hep.28952. Epub 2017 Jan 17. Hepatology. 2017. PMID: 27863453
Introduction of direct-acting antivirals against hepatitis C virus (HCV) has provided a revolutionary improvement in the treatment outcome. ...Importantly, PAC had a pan-genotypic anti-HBV activity and was also effective against a clinically relevant nucleosi …
Introduction of direct-acting antivirals against hepatitis C virus (HCV) has provided a revolutionary improvement in the treatment ou …
3,694 results
Jump to page
Feedback