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MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats.
Takashina K, Bessho T, Mori R, Eguchi J, Saito K. Takashina K, et al. J Neural Transm (Vienna). 2008 Jul;115(7):1027-35. doi: 10.1007/s00702-008-0048-1. Epub 2008 Apr 30. J Neural Transm (Vienna). 2008. PMID: 18446264
AF64A (3 nmol/brain, i.c.v.) produced significant reduction of high-affinity choline uptake (HACU) and high K+-induced ACh release in hippocampal synaptosomes. ...In hippocampal slices superfused with choline-containing artificial cerebro-spinal fluid (ACSF), high K
AF64A (3 nmol/brain, i.c.v.) produced significant reduction of high-affinity choline uptake (HACU) and high K+-induced ACh release in …
MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake.
Takashina K, Bessho T, Mori R, Kawai K, Eguchi J, Saito K. Takashina K, et al. J Neural Transm (Vienna). 2008 Jul;115(7):1037-46. doi: 10.1007/s00702-008-0049-0. Epub 2008 May 7. J Neural Transm (Vienna). 2008. PMID: 18461273
MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats.
Bessho T, Takashina K, Eguchi J, Komatsu T, Saito K. Bessho T, et al. J Neural Transm (Vienna). 2008 Jul;115(7):1019-25. doi: 10.1007/s00702-008-0053-4. Epub 2008 May 7. J Neural Transm (Vienna). 2008. PMID: 18461272
Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Kohara T, Nakayama K, Watanabe K, Kusaka SI, Sakai D, Tanaka H, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Mori A, Tanaka S, Bessho T, Takiguchi-Hayashi K, Horikawa T. Kohara T, et al. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3733-3738. doi: 10.1016/j.bmcl.2017.06.077. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712706
Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Usui Y, Uehara F, Hiki S, Watanabe K, Tanaka H, Shouda A, Yokoshima S, Aritomo K, Adachi T, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Yamagami K, Asano S, Tanaka S, Yuki S, Yoshii N, Fujimura M, Horikawa T. Usui Y, et al. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3726-3732. doi: 10.1016/j.bmcl.2017.06.078. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712708
Effects of a novel cognitive enhancer, spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on learning impairments induced by amyloid-beta1-40 in the rat.
Yamaguchi Y, Miyashita H, Tsunekawa H, Mouri A, Kim HC, Saito K, Matsuno T, Kawashima S, Nabeshima T. Yamaguchi Y, et al. J Pharmacol Exp Ther. 2006 Jun;317(3):1079-87. doi: 10.1124/jpet.105.098640. Epub 2006 Feb 10. J Pharmacol Exp Ther. 2006. PMID: 16474004
6-(4-Pyridyl)pyrimidin-4(3H)-ones as CNS penetrant glycogen synthase kinase-3β inhibitors.
Uehara F, Shoda A, Aritomo K, Fukunaga K, Watanabe K, Ando R, Shinoda M, Ueno H, Kubodera H, Sunada S, Saito K, Kaji T, Asano S, Eguchi J, Yuki S, Tanaka S, Yoneyama Y, Niwa T. Uehara F, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6928-32. doi: 10.1016/j.bmcl.2013.09.021. Epub 2013 Sep 17. Bioorg Med Chem Lett. 2013. PMID: 24094818
Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer's disease.
Fukunaga K, Sakai D, Watanabe K, Nakayama K, Kohara T, Tanaka H, Sunada S, Nabeno M, Okamoto M, Saito K, Eguchi J, Mori A, Tanaka S, Inazawa K, Horikawa T. Fukunaga K, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1086-91. doi: 10.1016/j.bmcl.2015.01.005. Epub 2015 Jan 13. Bioorg Med Chem Lett. 2015. PMID: 25655721
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