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Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.
Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Morishima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T; Japanese Alzheimer’s Disease Neuroimaging Initiative. Omori C, et al. Among authors: saito y. J Alzheimers Dis. 2014;39(4):861-70. doi: 10.3233/JAD-131610. J Alzheimers Dis. 2014. PMID: 24305499 Free article.
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T. Saito Y, et al. J Biol Chem. 2008 Dec 19;283(51):35763-71. doi: 10.1074/jbc.M801353200. Epub 2008 Oct 9. J Biol Chem. 2008. PMID: 18845544 Free PMC article.
The amyloidogenic, but not amyloidolytic, metabolism of APP was selectively increased in the brain of mutant mice lacking X11L (Sano, Y., Syuzo-Takabatake, A., Nakaya, T., Saito, Y., Tomita, S., Itohara, S., and Suzuki, T. (2006) J. ...
The amyloidogenic, but not amyloidolytic, metabolism of APP was selectively increased in the brain of mutant mice lacking X11L (Sano, Y …
Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system.
Konno T, Hata S, Hamada Y, Horikoshi-Sakuraba Y, Nakaya T, Saito Y, Yamamoto T, Yamamoto T, Maeda M, Ikeuchi T, Gandy S, Akatsu H, Suzuki T; Japanese Alzheimer's Disease Neuroimaging Initiative. Konno T, et al. Among authors: saito y. Mol Neurodegener. 2011 Nov 8;6:76. doi: 10.1186/1750-1326-6-76. Mol Neurodegener. 2011. PMID: 22067061 Free PMC article.
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T. Matsushima T, et al. Among authors: saito y. J Biol Chem. 2012 Jun 1;287(23):19715-24. doi: 10.1074/jbc.M111.334847. Epub 2012 Apr 17. J Biol Chem. 2012. PMID: 22511769 Free PMC article.
9,407 results