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Effectiveness of pirotiodecane, absorption enhancer, on nasal absorption in rabbits.
Otake H, Tomita M, Sugimoto M, Idota Y, Okuma K, Sakai M, Haga M, Hayashi M. Otake H, et al. Among authors: Sakai M. Drug Metab Pharmacokinet. 2005 Feb;20(1):65-71. doi: 10.2133/dmpk.20.65. Drug Metab Pharmacokinet. 2005. PMID: 15770076
The nasal epithelial mucosa was isolated from rabbit nasal septum and mounted in an Ussing chamber to allow for monitoring of the membrane resistance (Rm), and the permeation of fluorescein isothiocyanate-labeled dextran (FD-4, M.W. 4,400 Da). ...
The nasal epithelial mucosa was isolated from rabbit nasal septum and mounted in an Ussing chamber to allow for monitoring of the membrane r …
Cytotoxicity of absorption enhancers in Caco-2 cell monolayers.
Sakai M, Imai T, Ohtake H, Otagiri M. Sakai M, et al. J Pharm Pharmacol. 1998 Oct;50(10):1101-8. doi: 10.1111/j.2042-7158.1998.tb03319.x. J Pharm Pharmacol. 1998. PMID: 9821655
[Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (3). Teratogenicity study in rabbits].
Nishimura T, Nakagawa Y, Sakai M, Sugai S, Chihara N, Shirakawa R, Sakamoto T, Ikeda Y, Itagaki I, Ozeki Y, Shinomiya K, Fujita T. Nishimura T, et al. Among authors: Sakai M. J Toxicol Sci. 1998 Jul;23 Suppl 3:531-8. doi: 10.2131/jts.23.supplementiii_531. J Toxicol Sci. 1998. PMID: 9760410 Japanese.
[Toxicity studies of landiolol hydrochloride (ONO-1101) (2). 4-week repeated dose intravenous toxicity study in rats with 4-week recovery test].
Yamaguchi K, Yanagi H, Shimizu K, Sakai M, Nishibata K, Oida H, Shinomiya K, Suzuki Y, Yonezawa H, Fujita T. Yamaguchi K, et al. Among authors: Sakai M. J Toxicol Sci. 1997 Dec;22 Suppl 3:443-61. doi: 10.2131/jts.22.supplementiii_443. J Toxicol Sci. 1997. PMID: 9483475 Japanese.
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