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The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.
Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. Kawai N, et al. Among authors: Sakai N. Neuropsychopharmacology. 2015 May;40(6):1405-16. doi: 10.1038/npp.2014.326. Epub 2014 Dec 23. Neuropsychopharmacology. 2015. PMID: 25533534 Free PMC article.
Pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists AP5 and CGP78608 but not the glycine receptor antagonist strychnine inhibited the CBF increase caused by glycine injection into the brain. ...
Pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists AP5 and CGP78608 but not the glycine receptor antagonist strychnin …
Basal forebrain circuit for sleep-wake control.
Xu M, Chung S, Zhang S, Zhong P, Ma C, Chang WC, Weissbourd B, Sakai N, Luo L, Nishino S, Dan Y. Xu M, et al. Among authors: Sakai N. Nat Neurosci. 2015 Nov;18(11):1641-7. doi: 10.1038/nn.4143. Epub 2015 Oct 12. Nat Neurosci. 2015. PMID: 26457552 Free PMC article.
Intraperitoneal injection of ginkgolide B, a major active compound of Ginkgo biloba, dose-dependently increases the amount of wake and decreases non-rapid eye movement sleep in C57BL/6 mice.
Nishimon S, Yamaguchi M, Muraki H, Sakai N, Nishino S. Nishimon S, et al. Among authors: Sakai N. Neurosci Lett. 2020 Mar 23;722:134832. doi: 10.1016/j.neulet.2020.134832. Epub 2020 Feb 9. Neurosci Lett. 2020. PMID: 32050100
Noninvasive detection of sleep/wake changes and cataplexy-like behaviors in orexin/ataxin-3 transgenic narcoleptic mice across the disease onset.
Sato M, Sagawa Y, Hirai N, Sato S, Okuro M, Kumar S, Kanbayashi T, Shimizu T, Sakai N, Nishino S. Sato M, et al. Among authors: Sakai N. Exp Neurol. 2014 Nov;261:744-51. doi: 10.1016/j.expneurol.2014.08.004. Epub 2014 Aug 10. Exp Neurol. 2014. PMID: 25118620 Free PMC article.
An overview of hypocretin based therapy in narcolepsy.
Takenoshita S, Sakai N, Chiba Y, Matsumura M, Yamaguchi M, Nishino S. Takenoshita S, et al. Among authors: Sakai N. Expert Opin Investig Drugs. 2018 Apr;27(4):389-406. doi: 10.1080/13543784.2018.1459561. Epub 2018 Apr 9. Expert Opin Investig Drugs. 2018. PMID: 29623725 Review.
A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait.
Zhang L, Hirano A, Hsu PK, Jones CR, Sakai N, Okuro M, McMahon T, Yamazaki M, Xu Y, Saigoh N, Saigoh K, Lin ST, Kaasik K, Nishino S, Ptáček LJ, Fu YH. Zhang L, et al. Among authors: Sakai N. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1536-44. doi: 10.1073/pnas.1600039113. Epub 2016 Feb 22. Proc Natl Acad Sci U S A. 2016. PMID: 26903630 Free PMC article.
A register-based SAH study in Japan: high incidence rate and recent decline trend based on lifestyle.
Ikawa F, Morita A, Nakayama T, Goto Y, Sakai N, Iihara K, Shiokawa Y, Date I, Nozaki K, Kinouchi H, Houkin K, Saito N, Tominaga T, Suzuki M, Miyamoto S, Kurisu K, Arai H. Ikawa F, et al. Among authors: Sakai N. J Neurosurg. 2020 Mar 27:1-9. doi: 10.3171/2020.1.JNS192848. Online ahead of print. J Neurosurg. 2020. PMID: 32217794
Effects of lipid metabolism on mouse incisor dentinogenesis.
Kurotaki Y, Sakai N, Miyazaki T, Hosonuma M, Sato Y, Karakawa A, Chatani M, Myers M, Suzawa T, Negishi-Koga T, Kamijo R, Miyazaki A, Maruoka Y, Takami M. Kurotaki Y, et al. Among authors: Sakai N. Sci Rep. 2020 Mar 20;10(1):5102. doi: 10.1038/s41598-020-61978-0. Sci Rep. 2020. PMID: 32198436 Free PMC article.
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