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Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene.
Sakai T, Ohtani N, McGee TL, Robbins PD, Dryja TP. Sakai T, et al. Nature. 1991 Sep 5;353(6339):83-6. doi: 10.1038/353083a0. Nature. 1991. PMID: 1881452
Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line.
Nakano K, Mizuno T, Sowa Y, Orita T, Yoshino T, Okuyama Y, Fujita T, Ohtani-Fujita N, Matsukawa Y, Tokino T, Yamagishi H, Oka T, Nomura H, Sakai T. Nakano K, et al. Among authors: sakai t. J Biol Chem. 1997 Aug 29;272(35):22199-206. doi: 10.1074/jbc.272.35.22199. J Biol Chem. 1997. PMID: 9268365
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites.
Sowa Y, Orita T, Minamikawa S, Nakano K, Mizuno T, Nomura H, Sakai T. Sowa Y, et al. Among authors: sakai t. Biochem Biophys Res Commun. 1997 Dec 8;241(1):142-50. doi: 10.1006/bbrc.1997.7786. Biochem Biophys Res Commun. 1997. PMID: 9405248
Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites.
Huang L, Sowa Y, Sakai T, Pardee AB. Huang L, et al. Among authors: sakai t. Oncogene. 2000 Nov 23;19(50):5712-9. doi: 10.1038/sj.onc.1203963. Oncogene. 2000. PMID: 11126357
A silencer element in the retinoblastoma tumor-suppressor gene.
Ohtani-Fujita N, Fujita T, Takahashi R, Robbins PD, Dryja TP, Sakai T. Ohtani-Fujita N, et al. Among authors: sakai t. Oncogene. 1994 Jun;9(6):1703-11. Oncogene. 1994. PMID: 8183566
Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma.
Ohtani-Fujita N, Dryja TP, Rapaport JM, Fujita T, Matsumura S, Ozasa K, Watanabe Y, Hayashi K, Maeda K, Kinoshita S, Matsumura T, Ohnishi Y, Hotta Y, Takahashi R, Kato MV, Ishizaki K, Sasaki MS, Horsthemke B, Minoda K, Sakai T. Ohtani-Fujita N, et al. Among authors: sakai t. Cancer Genet Cytogenet. 1997 Oct 1;98(1):43-9. doi: 10.1016/s0165-4608(96)00395-0. Cancer Genet Cytogenet. 1997. PMID: 9309117
Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1.
Sowa Y, Shiio Y, Fujita T, Matsumoto T, Okuyama Y, Kato D, Inoue J, Sawada J, Goto M, Watanabe H, Handa H, Sakai T. Sowa Y, et al. Among authors: sakai t. Cancer Res. 1997 Aug 1;57(15):3145-8. Cancer Res. 1997. PMID: 9242441
ATF site of human RB gene promoter is a responsive element of myogenic differentiation.
Okuyama Y, Sowa Y, Fujita T, Mizuno T, Nomura H, Nikaido T, Endo T, Sakai T. Okuyama Y, et al. Among authors: sakai t. FEBS Lett. 1996 Nov 18;397(2-3):219-24. doi: 10.1016/s0014-5793(96)01178-7. FEBS Lett. 1996. PMID: 8955351
CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.
Ohtani-Fujita N, Fujita T, Aoike A, Osifchin NE, Robbins PD, Sakai T. Ohtani-Fujita N, et al. Among authors: sakai t. Oncogene. 1993 Apr;8(4):1063-7. Oncogene. 1993. PMID: 8455933
The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family.
Savoysky E, Mizuno T, Sowa Y, Watanabe H, Sawada J, Nomura H, Ohsugi Y, Handa H, Sakai T. Savoysky E, et al. Among authors: sakai t. Oncogene. 1994 Jul;9(7):1839-46. Oncogene. 1994. PMID: 8208529
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