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The role of host genetics in leishmaniasis.
Sakthianandeswaren A, Foote SJ, Handman E. Sakthianandeswaren A, et al. Trends Parasitol. 2009 Aug;25(8):383-91. doi: 10.1016/j.pt.2009.05.004. Epub 2009 Jul 18. Trends Parasitol. 2009. PMID: 19617002 Review.
As a complex disease, the pathology of leishmaniasis varies and is determined by factors such as the environment, the insect vector, and parasite and host genetics. ...
As a complex disease, the pathology of leishmaniasis varies and is determined by factors such as the environment, the insect vector, …
Cutaneous leishmaniasis in red kangaroos: isolation and characterisation of the causative organisms.
Rose K, Curtis J, Baldwin T, Mathis A, Kumar B, Sakthianandeswaren A, Spurck T, Low Choy J, Handman E. Rose K, et al. Among authors: sakthianandeswaren a. Int J Parasitol. 2004 May;34(6):655-64. doi: 10.1016/j.ijpara.2004.03.001. Int J Parasitol. 2004. PMID: 15111087
Despite a clear indication that the parasites belong to the genus Leishmania, no assignation to a known Leishmania species could be made using these or other less conserved genetic loci such as the non-transcribed spacer of the mini-exon repeat. ...
Despite a clear indication that the parasites belong to the genus Leishmania, no assignation to a known Leishmania species cou …
The wound repair response controls outcome to cutaneous leishmaniasis.
Sakthianandeswaren A, Elso CM, Simpson K, Curtis JM, Kumar B, Speed TP, Handman E, Foote SJ. Sakthianandeswaren A, et al. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15551-6. doi: 10.1073/pnas.0505630102. Epub 2005 Oct 13. Proc Natl Acad Sci U S A. 2005. PMID: 16223880 Free PMC article.
Wound healing response is a major contributor to the severity of cutaneous leishmaniasis in the ear model of infection.
Baldwin T, Sakthianandeswaren A, Curtis JM, Kumar B, Smyth GK, Foote SJ, Handman E. Baldwin T, et al. Among authors: sakthianandeswaren a. Parasite Immunol. 2007 Oct;29(10):501-13. doi: 10.1111/j.1365-3024.2007.00969.x. Parasite Immunol. 2007. PMID: 17883453
In that model, we showed that wound healing and not T cell responses played a major role in determining the resolution of skin infection. Here, we show a similar disease phenotype in the mouse model that mimics more closely the situation in humans, that is, strictly …
In that model, we showed that wound healing and not T cell responses played a major role in determining the resolution of skin infect …
Leishmaniasis: current treatment and prospects for new drugs and vaccines.
Kedzierski L, Sakthianandeswaren A, Curtis JM, Andrews PC, Junk PC, Kedzierska K. Kedzierski L, et al. Among authors: sakthianandeswaren a. Curr Med Chem. 2009;16(5):599-614. doi: 10.2174/092986709787458489. Curr Med Chem. 2009. PMID: 19199925 Review.
Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement and fatal systemic infection. WHO estimates that the disease results in 2 million new cases a year, threatens 350 million people in 88 countries and that there are 12 milli …
Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement and fatal systemic infection. WHO estim …
Fine mapping of Leishmania major susceptibility Locus lmr2 and evidence of a role for Fli1 in disease and wound healing.
Sakthianandeswaren A, Curtis JM, Elso C, Kumar B, Baldwin TM, Lopaticki S, Kedzierski L, Smyth GK, Foote SJ, Handman E. Sakthianandeswaren A, et al. Infect Immun. 2010 Jun;78(6):2734-44. doi: 10.1128/IAI.00126-10. Epub 2010 Apr 5. Infect Immun. 2010. PMID: 20368343 Free PMC article.
We now describe the contribution of a novel candidate gene, Fli1, to both L. major resistance and enhanced wound healing. We have previously mapped the L. major response locus, lmr2, to proximal chromosome 9 in a genetic cross between the resistant C57BL/6 strain an …
We now describe the contribution of a novel candidate gene, Fli1, to both L. major resistance and enhanced wound healing. We have pre …
PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.
Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. Sakthianandeswaren A, et al. Cancer Res. 2011 May 15;71(10):3709-19. doi: 10.1158/0008-5472.CAN-10-2342. Epub 2011 May 10. Cancer Res. 2011. PMID: 21558389
In small adenomas, PHLDA1 was expressed in a subset of undifferentiated and predominantly Ki-67-negative neoplastic cells, suggesting that a basic hierarchy of differentiation is retained in early tumorigenesis. ...We conclude that PHLDA1 is a putative epithe …
In small adenomas, PHLDA1 was expressed in a subset of undifferentiated and predominantly Ki-67-negative neoplastic cells, suggesting …
Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes.
Williams DS, Mouradov D, Jorissen RN, Newman MR, Amini E, Nickless DK, Teague JA, Fang CG, Palmieri M, Parsons MJ, Sakthianandeswaren A, Li S, Ward RL, Hawkins NJ, Faragher I, Jones IT, Gibbs P, Sieber OM. Williams DS, et al. Among authors: sakthianandeswaren a. Gut. 2019 Mar;68(3):465-474. doi: 10.1136/gutjnl-2017-315664. Epub 2018 Jan 30. Gut. 2019. PMID: 29382774
Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.
Christie M, Jorissen RN, Mouradov D, Sakthianandeswaren A, Li S, Day F, Tsui C, Lipton L, Desai J, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Burgess AW, Busam D, Zhao Q, Strausberg RL, Simpson AJ, Tomlinson IP, Gibbs P, Sieber OM. Christie M, et al. Among authors: sakthianandeswaren a. Oncogene. 2013 Sep 26;32(39):4675-82. doi: 10.1038/onc.2012.486. Epub 2012 Oct 22. Oncogene. 2013. PMID: 23085758 Free PMC article.
Most truncating mutations occurred within a mutation cluster region (MCR; codons 1282-1581) leaving 1-3 intact 20 amino-acid repeats (20AARs) and abolishing all Ser-Ala-Met-Pro (SAMP) repeats. ...Proximal and distal cancers exhibited different preferred APC genotypes, leav …
Most truncating mutations occurred within a mutation cluster region (MCR; codons 1282-1581) leaving 1-3 intact 20 amino-acid repeats …
PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.
Day FL, Jorissen RN, Lipton L, Mouradov D, Sakthianandeswaren A, Christie M, Li S, Tsui C, Tie J, Desai J, Xu ZZ, Molloy P, Whitehall V, Leggett BA, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Busam D, Zhao Q, Strausberg RL, Gibbs P, Sieber OM. Day FL, et al. Among authors: sakthianandeswaren a. Clin Cancer Res. 2013 Jun 15;19(12):3285-96. doi: 10.1158/1078-0432.CCR-12-3614. Epub 2013 Apr 30. Clin Cancer Res. 2013. PMID: 23633456 Free article.
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