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Year Number of Results
1990 2
1991 3
1992 9
1993 7
1994 6
1995 4
1996 3
1997 2
1998 4
1999 9
2000 7
2001 5
2002 11
2003 8
2004 12
2005 10
2006 14
2007 7
2008 12
2009 14
2010 9
2011 10
2012 5
2013 15
2014 8
2015 9
2016 9
2017 9
2018 7
2019 3
2020 6
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223 results
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Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.
Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y. Bassetti CLA, et al. Among authors: sakurai t. Nat Rev Neurol. 2019 Sep;15(9):519-539. doi: 10.1038/s41582-019-0226-9. Epub 2019 Jul 19. Nat Rev Neurol. 2019. PMID: 31324898 Review.
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also known as hypocretin) neurons of the lateral hypothalamus. ...This Review focuses on our current understanding of how genetic, environmental and immune-related factors c …
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also known as hypocretin) neurons …
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Sakurai T, et al. Among authors: yanagisawa m. Cell. 1998 Feb 20;92(4):573-85. doi: 10.1016/s0092-8674(00)80949-6. Cell. 1998. PMID: 9491897 Free article.
We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant struct …
We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate tw …
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.
Sakurai T. Sakurai T. Nat Rev Neurosci. 2007 Mar;8(3):171-81. doi: 10.1038/nrn2092. Epub 2007 Feb 14. Nat Rev Neurosci. 2007. PMID: 17299454 Review.
The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis....
The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward …
Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M. Irukayama-Tomobe Y, et al. Among authors: sakurai t, yanagisawa m. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5731-5736. doi: 10.1073/pnas.1700499114. Epub 2017 May 15. Proc Natl Acad Sci U S A. 2017. PMID: 28507129 Free PMC article.
Intraperitoneal, and intracerebroventricular, administration of YNT-185 suppressed cataplexy-like episodes in orexin knockout and orexin neuron-ablated mice, but not in orexin receptor-deficient mice. ...Further, there was no immediate rebound sleep after YNT …
Intraperitoneal, and intracerebroventricular, administration of YNT-185 suppressed cataplexy-like episodes in orexin knockout and …
Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit.
Soya S, Sakurai T. Soya S, et al. Among authors: sakurai t. Brain Res. 2020 Mar 15;1731:146037. doi: 10.1016/j.brainres.2018.11.032. Epub 2018 Nov 24. Brain Res. 2020. PMID: 30481504 Review.
Orexin neurons in the hypothalamus send excitatory innervations to noradrenergic neurons in the locus coeruleus (NA(LC)) which express orexin receptor 1 (OX1R) and send projections to the lateral amygdala (LA). ...Our recent observation suggests that the orexin
Orexin neurons in the hypothalamus send excitatory innervations to noradrenergic neurons in the locus coeruleus (NA(LC)) which expres
A discrete neuronal circuit induces a hibernation-like state in rodents.
Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T. Takahashi TM, et al. Among authors: yanagisawa m, sakurai t. Nature. 2020 Jul;583(7814):109-114. doi: 10.1038/s41586-020-2163-6. Epub 2020 Jun 11. Nature. 2020. PMID: 32528181
Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture.
Saito YC, Tsujino N, Abe M, Yamazaki M, Sakimura K, Sakurai T. Saito YC, et al. Among authors: sakurai t. Front Neurosci. 2018 Nov 30;12:892. doi: 10.3389/fnins.2018.00892. eCollection 2018. Front Neurosci. 2018. PMID: 30555297 Free PMC article.
Neurons expressing neuropeptide orexins (hypocretins) in the lateral hypothalamus (LH) and serotonergic neurons in the dorsal raphe nucleus (DR) both play important roles in the regulation of sleep/wakefulness states, and show similar firing patterns across s …
Neurons expressing neuropeptide orexins (hypocretins) in the lateral hypothalamus (LH) and serotonergic neurons in the …
Sleep Control, GPCRs, and Glucose Metabolism.
Tsuneki H, Sasaoka T, Sakurai T. Tsuneki H, et al. Among authors: sakurai t. Trends Endocrinol Metab. 2016 Sep;27(9):633-642. doi: 10.1016/j.tem.2016.06.011. Epub 2016 Jul 22. Trends Endocrinol Metab. 2016. PMID: 27461005 Review.
Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including γ-aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. ...
Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including γ-aminobutyr …
Orexin modulates behavioral fear expression through the locus coeruleus.
Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T. Soya S, et al. Among authors: sakurai t. Nat Commun. 2017 Nov 20;8(1):1606. doi: 10.1038/s41467-017-01782-z. Nat Commun. 2017. PMID: 29151577 Free PMC article.
Emotionally salient information activates orexin neurons in the lateral hypothalamus, leading to increase in sympathetic outflow and vigilance level. ...Pharmacogenetic/optogenetic silencing of this circuit as well as acute blockade of the orexin receptor-1 (OX1R) d …
Emotionally salient information activates orexin neurons in the lateral hypothalamus, leading to increase in sympathetic outflow and …
Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons.
Saito YC, Maejima T, Nishitani M, Hasegawa E, Yanagawa Y, Mieda M, Sakurai T. Saito YC, et al. Among authors: mieda m, sakurai t. J Neurosci. 2018 Jul 11;38(28):6366-6378. doi: 10.1523/JNEUROSCI.2835-17.2018. Epub 2018 Jun 18. J Neurosci. 2018. PMID: 29915137 Free PMC article.
While the ventrolateral preoptic nucleus (VLPO) plays a critical role in the initiation and maintenance of sleep, the lateral posterior part of the hypothalamus contains neuronal populations implicated in maintenance of arousal, including orexin-producing neurons (orexi
While the ventrolateral preoptic nucleus (VLPO) plays a critical role in the initiation and maintenance of sleep, the lateral posterior part …
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